Did you say PINK?? Do you remember if they where KVK tech???
I also towards the " beginning" or middle of my opiod usage, I used to take ANY tablets -- sometimes it was Percs with APAP, but most often if was the 30mg blue tablets (Activas I believe). I cut them in half and took 15mg per dose. EVERYtime 15mg had me buzzing like crazy full of energy and motivation and no pain!
Then one day I took some pink, 10mg IR tablets. I took 1 and a half (to equal my normal 15mg) dosage. I didn't feel anything. I was like wtf is going on??? Then an hour after I went into WD! I thought they where fake as I never had pink ones before, so looked them up, nope they where 10mg IR pills alright. So then I thought that maybe it's because I had "less to eat" with my dosage then normal so that's why it didn't work. As I normally ALWAYS eat a fatty meal with a dosage and if boosts it big, big time for me. So then while still in W/D (I waited a full 2 hours to make sure they weren't delayed absorption or something going on) and 2 hours later I tried same dosage with a fatty meal... It didn't give me any buzz at all, but by the 2nd dosage removed the W/D so I got through the night working. I remember taking them again on a different day and again felt nothing.
Then I went back to the blue Activas, and with the same dosage I was right back to major pain relief, energy, buzz/whatever you want to call it..... Huge difference. That itself made me think wtf? That's impossible.
That's when I started to research about generics vs brand name, and how each generic are NOT MADE THE SAME. I read news articles, read countless studies, all showed there was a major difference. The most damning thing was a court hearing on generic medications, and how in a certain percentage of population that many of the common fillers used in generic can make the active ingrident become basically null, or, the fillers would vastly effect the absorption of the active ingridents -- but they went on to show on it depends on the person.
Just as how some people have no issues with CYP26 and others do -- and that can make the bioavability of certain drugs (like Hydrmorphone) range from 95% of the drug is absorbed in person A, wbile in person B only
25% of the drug is absorbed. HUGE differences, and it all varies by person. Then add in all the extra fillers and it varying by each generic company and you can have vastly different results with one generic vs another, yet another person is able to take them all the same.
Same with generics and their fillers, binders, dyes -- and you name it that are put into generics (and each generic have different fillers, binders, etc). A certain filler may cause person A to have no affect to the filler and absorb the active ingrident well, say 80% bioavability. While person B, due to the fillers, their body doesn't react well with it and that fillers affects the absorption of the active ingrident dropping the bioavability or plasma levels of the drug only to 30%. Huge difference.
That why some SWEAR generics are all the same (that would be person A) while others like person B they SWEAR there is a difference. There are too many studies, articles, and even court hearings and lawsuits that show yes there IS a difference, but it depends if you are person A or person B if you'll notice the difference -- or you may be person C, a mix of both, where sometimes it happens and your body can't handle certain fillers/etc and other times it can.
