- Feb 23, 2004
Thanks for the info and the warning,I really appreciate it. I was gonna use flouros instead of my high pressure sodium lights because of the heat my HPS gives off . I have 2 4 foot long flouros housed under a reflector. I have 2 sets of these lights so maybe I won't quit my pain meds just yet,lol!
I think one of the biggest problems with Opium/poppies is also one of its least talked about.
So the so called addiction/withdrawal effect of opium is far worse than say just heroin. See there are 6 major opiates in Opium; morphine, narcotine, codeine, thebaine, papaverine and narceine. Each of these have their own metabolites. As is the case with heroin it is metabolised into two substances. M3G and M6G, M6G being the stuff that makes you high. Now the withdrawals from heroin are a direct result of the activation of TL4 by M3G. Toll Like 4 Receptors when activated are responsible for some awful shit called proinflammatory cytokines which cause depression, restless leg, sweats, fevers, pain and so on.
Intriguingly, TLR4 is activated by morphine-3-glucoronide (M3G), a morphine metabolite that is inactive at classical opioid receptors, but not by morphine-6-glucoronide (M6G), the opioid receptor active metabolite45,46. Along with nonstereoselectivity, the TLR4 signaling activation by M3G, but not M6G, points to a major difference from the structure activity relationship of the opioid receptor with the reliance of 4,5-epoxymorphinans on the 3’OH for classical opioid receptor activity but not for TLR4 activity. M3G action at TLR4 predicts that intrathecal M3G would induce pain enhancement mediated by TLR4, microglia (given their predominance in TLR4 expression), and proinflammatory cytokines (a downstream product of TLR4 activation). Indeed, this is the case46. TLR4 activation by opioids is now implicated in opposing acute and chronic opioid analgesia, and contributing to opioid-induced hyperalgesia, dependence and reward
It appears that most of these other opiates breakdown in a similar fashion with their M3G version going to TL4 and further activating them. It would appear the long you use opiates the greater the activation effect. There appears to be other things going on that they haven't yet identified because its not clear why a opiate naive person doesn't go into immediate withdrawal compared to a long term user.
From the ancedontal reports I've read across bluelight, erowid, drugs.com and several other forums its clear to me that people who use opiates have a really hard time kicking them, far worse than heroin. Some of those opiates in the opium have much longer half-lifes than heroin, consequently your in much greater pain and discomfort as your body finally gets rid of these drugs from your system. Also the ROA is really important with opium. Smoking Opium will result in some serious damage. Whilst with the tea it is almost impossible to calculate your dose. I've been tempted to grow opium to convert into morphine and such but I personally know that i'll end up getting lazy and smoking the shit which will really lead to some difficult situations.
This is the reason why despite having the means to grow large amounts of poppies that I have stayed away from it. The pain and discomfort of heroin withdrawals are worse enough without the pain and misery of opiate metabolites that last significantly longer in my system.