Nicomorphinist
Bluelighter
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- Apr 18, 2019
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Anyone know more or can clarify or correct anything? Here we go:
Myrophine -- This is an active metabolite of the antitussive benzylmorphine (Peronine) which was investigated in the 1960s and 1970s as an analgesic for recovering addicts for surgery, pain and so forth.
3,6 Morphine esters -- Diacetylmorphine (heroin, diamorphine) as a 3,6 acetyl diester of morphine, and many of these compounds were invented by the CR Alders Wright organisation at St Marys Hospital in London in the period 1874-1876 and some later research on the Continent. The inventors' idea was to find a less addictive derivative of morphine. These compounds were rediscovered, by Merck in Elberfield and Darmstadt, Germany and others, starting in the late 1890s. There were 3 and 6 mono esters, 3,6 diesters, 3,6,14 triesters and 3,6,8,14 tetra esters of morphine, codeine, isomorphine, isocodeine, normorphine, dihydrocodeine, dihydromorphine, and ones for the 14-dihydromorphinones like oxymorphone were discovered in Austria 1929 to about 1938. One ester of hydrocodone is thebacon, one ester of hydromorphone is acetlymorphone, and an oxymorphone ester is 3,6,14-triacetyloxymorphone.
There are esters with one, two, or a mixture of two or more of the following: nicotinyl, benzoyl, salicoyl, formoyl, butyl, butryl, acetyl, propanonyl, isopropanoyl and probably others. After the League of Nations put treaties into force against heroin in 1924, Merck and other firms started producing metric ton quantities of acetylmorphone, dibenzoylmorphine, and acetylpropanoylmorphine. The League of Nations declared that they were, as a result of being almost indistinguishable from heroin when injected that these mountains of drugs were being produced only to support addiction, which could very well have been the intent of people in these companies who were sympathetic to people who would get very sick without them, and the loophole closed in 1930. They were, in fact, the first designer drugs.
A patent was granted and information disseminated via the Austrian scientific journal Monatshefte für Chemie in 1957 and the same year Lannacher Heilmittel Ges.m.b.H. of Austria began producing nicomorphine and nicocodeine. To this day, both are used in Central Europe, Eastern Europe, and some of the Russian Near Abroad. It has actions very much like heroin and is used for surgery, Patient Controlled Analgesia, and other pain; in fact the author swears by it. Nicocodeine has a dihydrocodeine analogue called nicodicodeine and both are about as strong as hydrocodone with faster onset.
Morphine-N-Oxide -- Along with its codeine, hydromorphone and oxycodone analogues, this is a weak opioid which also forms as a decomposition product of the drugs in queston. These amide oxides are known by names like Genomorphine and Genocodeine.
2,4-Dinitrophenylmorphine -- This morphine derivative was first synthesised in Austria in 1931 with the idea of reducing the respiratory depression of morphine. The chemical which is attached to the 2 and 4 positions on the carbon-nitrogen skeleton arise in fact a second drug, 2,4-dinitrophenylhydrazine, a respiratory and metabolic stimulant.
Azidomorphine -- An azide group is attached to the 6 positiion making it 50 times as potent as morphine. Research on this began circa 1968.
Chloromorphide -- The halogenomorphides are fluoro, chloro, iodo, and bromo analogues of the first discovered, chloromorphide, in Austria in 1915. Chloromorphide is 10 times stronger than morphine and has a structural relationship to desomorphine that results in the alpha-chlorocodide process of making desomorphine, aka Krokodil. Bromomorphide, which the structure seems to show being in the same range is an intermediate in the synthesis of other drugs used to this day. The morphides, codides, dihydrocodides, dihydromorphides and any hydrocodomorphides and the like should not be confused with 1-iodomorphine, 2-chlorocodeine, 1,2-bromodihydromorphine so on. These drugs are more potent than the parent drugs by a modest percentage. 1-Iodomorphine radiolabelled with Iodine 129, 131 and 137 was used in the research from 1970 onwards which discovered opioid receptors, with other big ones being tritium-labelled dihydromorphine, levorphanol, and cyclazocine.
Heterocodeine -- Codeine is rearranged by switching the groups on the 3 and 6 positions to make a drug 81 to 108 times stronger. Invnted in Germany in 1932.
Myrophine -- This is an active metabolite of the antitussive benzylmorphine (Peronine) which was investigated in the 1960s and 1970s as an analgesic for recovering addicts for surgery, pain and so forth.
3,6 Morphine esters -- Diacetylmorphine (heroin, diamorphine) as a 3,6 acetyl diester of morphine, and many of these compounds were invented by the CR Alders Wright organisation at St Marys Hospital in London in the period 1874-1876 and some later research on the Continent. The inventors' idea was to find a less addictive derivative of morphine. These compounds were rediscovered, by Merck in Elberfield and Darmstadt, Germany and others, starting in the late 1890s. There were 3 and 6 mono esters, 3,6 diesters, 3,6,14 triesters and 3,6,8,14 tetra esters of morphine, codeine, isomorphine, isocodeine, normorphine, dihydrocodeine, dihydromorphine, and ones for the 14-dihydromorphinones like oxymorphone were discovered in Austria 1929 to about 1938. One ester of hydrocodone is thebacon, one ester of hydromorphone is acetlymorphone, and an oxymorphone ester is 3,6,14-triacetyloxymorphone.
There are esters with one, two, or a mixture of two or more of the following: nicotinyl, benzoyl, salicoyl, formoyl, butyl, butryl, acetyl, propanonyl, isopropanoyl and probably others. After the League of Nations put treaties into force against heroin in 1924, Merck and other firms started producing metric ton quantities of acetylmorphone, dibenzoylmorphine, and acetylpropanoylmorphine. The League of Nations declared that they were, as a result of being almost indistinguishable from heroin when injected that these mountains of drugs were being produced only to support addiction, which could very well have been the intent of people in these companies who were sympathetic to people who would get very sick without them, and the loophole closed in 1930. They were, in fact, the first designer drugs.
A patent was granted and information disseminated via the Austrian scientific journal Monatshefte für Chemie in 1957 and the same year Lannacher Heilmittel Ges.m.b.H. of Austria began producing nicomorphine and nicocodeine. To this day, both are used in Central Europe, Eastern Europe, and some of the Russian Near Abroad. It has actions very much like heroin and is used for surgery, Patient Controlled Analgesia, and other pain; in fact the author swears by it. Nicocodeine has a dihydrocodeine analogue called nicodicodeine and both are about as strong as hydrocodone with faster onset.
Morphine-N-Oxide -- Along with its codeine, hydromorphone and oxycodone analogues, this is a weak opioid which also forms as a decomposition product of the drugs in queston. These amide oxides are known by names like Genomorphine and Genocodeine.
2,4-Dinitrophenylmorphine -- This morphine derivative was first synthesised in Austria in 1931 with the idea of reducing the respiratory depression of morphine. The chemical which is attached to the 2 and 4 positions on the carbon-nitrogen skeleton arise in fact a second drug, 2,4-dinitrophenylhydrazine, a respiratory and metabolic stimulant.
Azidomorphine -- An azide group is attached to the 6 positiion making it 50 times as potent as morphine. Research on this began circa 1968.
Chloromorphide -- The halogenomorphides are fluoro, chloro, iodo, and bromo analogues of the first discovered, chloromorphide, in Austria in 1915. Chloromorphide is 10 times stronger than morphine and has a structural relationship to desomorphine that results in the alpha-chlorocodide process of making desomorphine, aka Krokodil. Bromomorphide, which the structure seems to show being in the same range is an intermediate in the synthesis of other drugs used to this day. The morphides, codides, dihydrocodides, dihydromorphides and any hydrocodomorphides and the like should not be confused with 1-iodomorphine, 2-chlorocodeine, 1,2-bromodihydromorphine so on. These drugs are more potent than the parent drugs by a modest percentage. 1-Iodomorphine radiolabelled with Iodine 129, 131 and 137 was used in the research from 1970 onwards which discovered opioid receptors, with other big ones being tritium-labelled dihydromorphine, levorphanol, and cyclazocine.
Heterocodeine -- Codeine is rearranged by switching the groups on the 3 and 6 positions to make a drug 81 to 108 times stronger. Invnted in Germany in 1932.
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