my step mom gets 90 40mg Opana ERs every month and i usually get about 20 - 30 of them from her and my dad. i crush them up and do 20 mgs about 3 times a day. I haven't really had w/ds but i have a couple of lortabs and 30mg codeines to lean on b/w prescriptions. however, it deffinitely does what people say to your tolerance. after doing just one, the next day i have taken as many as 9- 10mg lortabs and felt nothing.