• N&PD Moderators: Skorpio | thegreenhand

Nociceptin Antibody

Corazon

Bluelighter
Joined
May 20, 2013
Messages
1,373
(Nociceptin or) "N/OFQ is a heptadecapeptide, similar to
endogenous opioid peptides; particularly dynorphin
A and it opposes the analgesic effect of morphine after
intracerebroventricular (icv) injection5. The antiopioid
status of nociceptin is confirmed by the fact
that icv administration of antibody against nociceptin
reverses chronic morphine tolerance by about 50 per
cent in rat."

Anyone on bluelight know the deal here ?
Sounds amazing.
ICV as the ROA does not (they are bypassing the blood brain barrier by injecting into the ventricles of the brain). no thank you.
also have no idea how the body would adapt(long term, besides just reducing tolerance) to having it's nociceptin reduced.

still interesting. Any thoughts ?
nociceptin seems like an alternative contribution to tolerance, besides just the body's regulation of opiate receptors.
 
too abstract?
already been covered?

The antibody that neutralizes nociceptin will significantly reduce opiate tolerance, but has to cross the blood brain barrier.

Here's an idea/thought(maybe a dumb one?) - If we took nociceptin in a pill or whatever ROI, - in the short term we would probably ruin(worsen, increase) our tolerance to opiates, probably even our natural endogenous opioids.

Weird to think of inducing withdrawals in someone with no opiate use.

But beyond that stuff, would our body adapt in some way? Would we start to produce nociceptin antibody? Would we increase production of endogenous opiates?

Anywayz I think this stuff is interesting. We treat chronic pain with opiates, but opiates, while they work great in the short-term, reduce endogenous production, they lead to regulated receptors, and the lead to nociceptin production,...

thoughts? criticisms?? admonishments for upping my own thread???
 
As soon as a protein has to cross the BBB it's poor target. However, targeting this system is an interesting concept, you'd probably have better luck with small molecule antagonists due to BBB permeability, but there are also issues with the physiological functions of nociceptin to consider. A good starting place would be to look at its peripheral actions and basal concentrations.

Interesting, but you should do some legwork on pubmed to get some more material before people really start biting into a concept.

EA
 
Top