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News: Risk of overdose soars as ecstasy users chase a longer high (12/10/2004)

shal

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Risk of overdose soars as ecstasy users chase a longer high

Click here to read SMH Article



One in four ecstasy users is taking antidepressants and other pharmaceuticals to heighten the effect of the drug, dramatically increasing the risk of overdosing, a study has found.

The National Drug and Alcohol Research Centre survey found 25 per cent of 216 ecstasy users - mostly young, well-educated, inner-Sydney residents - were combining the drug with prescription pills for an extra "rush". Mixers were mostly men and long-term users, who supplemented their ecstasy intake with Viagra, benzodiazepines and antidepressants, to boost the high and help soften the comedown. They reported side effects such as muscle rigidity, nausea, severe headaches and profuse sweating.

Drug experts said combining ecstasy with antidepressants could quickly lead to serotonin syndrome, a condition that causes the body to go into meltdown and is responsible for a handful of deaths in Australia each year.

Serotonin - released by ecstasy - is a chemical in the brain that stimulates happy feelings. Antidepressants prevent the re-uptake of serotonin into the body, prolonging the rush.

Associate Professor Gordian Fulde, director of emergency services at St Vincent's Hospital, described the results as "a frightening example of how misinformed many young people are

... If people think they'll get an extra kick out of benzos, they're wrong, because benzos have a calming effect."

The National Drug and Alcohol Research Centre's spokesman, Paul Dillon, said the chances of overdosing were "drastically increased" when ecstasy was used with antidepressants. "I've seen one case and it was just about the most horrible thing I've ever seen - a young man who was so hot you couldn't physically touch him," Mr Dillon said. "The body can't cope with the huge serotonin rush and it melts."

The study found most drug mixers were given pharmaceuticals by their friends, and men in their 20s were procuring Viagra prescriptions easily from their doctors. "We thought they'd be getting [Viagra] from the internet, but we found that a lot of young men in their 20s were getting it prescribed, no questions asked," Mr Dillon said. "The study has raised a number of concerns for primary health care practitioners and pharmacists about how easily these products are distributed. People can get antidepressants anywhere."

A 2001 National Drug Strategy household survey found that ecstasy was the third most popular illicit substance, after cannabis and amphetamines. Of all people aged over 14 years, 6 per cent had used ecstasy.



Wow. Some people are really misinformed. Benzos and Ecstasy? Huh? 8( <--- Maybe on the comedown!
 
Wow, that was actually a pretty good article. That's a shock.
 
Hmmm. Indeed! Make sure you avoid MAOI's and MDMA. You are indeed to most likely melt. Not a very pleasent experience!
 
Hmm...I would agree that a lot of people are mixing E with other drugs, but I don't think that one in four people are mixing ecstasy with MAOIs...
 
I'd describe Associate Professor Gordian Fulde's comment as a frighten example of not contextualising the results into the lives of this particular group of drug users.

I highly doubt that it indicates that people are "wrong" about the effects of benzos. Just because alcohol is a depressant and relaxant, doesn't mean that people don't get a 'high' or 'kick' from it.

It's a little misleading if Paul Dillon is referring to MAOI antidepressants if the sample's use of antidepressants is mainly SSRI's.

Hope to find out more information if the full report becomes available.
 
I don't like this article... the way I read it, it makes it sound like 25% of the ecstasy taking population is trying to supplement their high with other pharms. I doubt this is true. A lot of people use benzos and antidepressants on the comedown, when they want some relief or get some sleep - not to get higher.

Don't antidepressants kill the roll anyway?
 
I agree that the article may misrepresent/have confused the situation. It appears to not make the distinction between users taking benzos whilst high and taking SSRIs to ameliorate the comedown. I think they've then gone and asked medical experts about the possible consequences of combining serotonergic drugs --> serotonin syndrome. The article seems to imply people are taking SSRIs to enhance the high, which wouldn't even work anyway.

I'm not aware of any death from using SSRIs on the comedown -- anyone know of one?

Articles like this merely serve to heighten community outrage at drug use where it is not necessarily justified. People with depression should have prompt and efficacious treatment. They should not be denied access to SSRIs because they might be pill users. Indeed, as SSRIs blcck the effects of pills one might even encourage this practice as it combats MDMA abuse. (I don't actually encourage unnecessary prescription of SSRIs, I'm just positing a possible argument)
 
Good article, its suprising the amount of people dont think mixing prescribed medications and illegal drugs dont cause serious adverse effects.
 
I'm never sure if Paul Dillon is one of the most mis-quoted persons working in the field of drug/alcohol use/abuse, but often when he is quoted in an article or tv program most of what he seems to be saying is total bollocks in my opinion. He is either badly misquoted/editted, or in an effort to simply his message he gets everything arse about, and causes either more confusion or yet another urban myth.

If there was such a high percentage of young males using e + viagra combo then the emergency departments would be full of painfully enduring youthful erections looking for a comedown, ie, priapism.
 
eccitude said:
I'm never sure if Paul Dillon is one of the most mis-quoted persons working in the field of drug/alcohol use/abuse, but often when he is quoted in an article or tv program most of what he seems to be saying is total bollocks in my opinion. He is either badly misquoted/editted, or in an effort to simply his message he gets everything arse about, and causes either more confusion or yet another urban myth.

If there was such a high percentage of young males using e + viagra combo then the emergency departments would be full of painfully enduring youthful erections looking for a comedown, ie, priapism.
What did he do thats "misquoted/editted"?
I thought it was a fairly good article, however not new news it was still good to see a newspaper article highlighting the dangers to other people who wouldn't understand?
and also why do emergency departments have to be full for something to be done? Also you can use viagra during a pill to fight the common "erectile disfunction" of a pill, it defenitely can make a good combo in certain cases.
It didn't say high percentage of e + viagra... but "One in four ecstasy users is taking antidepressants and other pharmaceuticals". Also for whoever that he said one in four are taking MAOI's, he was also referring to other pharmacuticals in that "one in four".

Like I said, I don't understand what was so "confusing" or "mythical" about that report..?
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