natural KOR agonists & antagonists/role in addiction

[asecin]

help me compile all natural k-opioid receptor agonists and antagonists please.

from wikipedia i got only few;
amentoflavone, salvinorin a, ibogaine, menthol and erinacine e

besides that i have a question. it says the KOR agonists help with addiction while the antagonists can encourage addiction; "KOR antagonist markedly increased alcohol consumption in lab animals"
so, naltrexone being anti-addictive substance is ANTAGONIST so how does that make sense, can someone help me understand this better please.

 

[polymath]

The alkaloids in the picralima nitida tree are also kappa ligands. Naltrexone also blocks mu receptors, which prevents drug-induced euphoria (not only that of opioids, but alcohol and stimulants too).

 

[asecin]

wouldnt it also block the pleasure from food and excercise as well? they can affect those receptors just like drugs. im going to have to find reports of people using it long term and see how dysphoric they have become over time

 

[asecin]

does anyone know if kratom is KOR agonist or antagonist?

 

[Xorkoth]

I wasn't aware of it being either, but I'm sure an agonist if it is either.