Tchort
Bluelight Crew
- Joined
- Mar 25, 2008
- Messages
- 2,392
They're going too far.
All for naught, as well. All for fucking naught.
It all started with Talwin; a few low-level healthcare workers came up with the T's & Blues combination, and shooting Pentazocine (which was unscheduled at the time) and Pyribenzamine (a.k.a. Tripellenamine, a common Rx cold/flu anti-Histamine of the day) spread across the country.
Then it started: Talwin NX. Pentazocine and Naloxone, combined in one pill. To stop intravenous abuse, they said. And it did: only, abuse never stopped, it just switched to oral and insufflation. A new combination was then discovered to be adequately euphoric to abuse: Talwin NX and Ritalin.
All was quiet for a couple decades, then Reckitt-Benckiser hit the lottery with their orphan drug Buprenorphine, owning the patents and branding rights for all of the Bupe products. The magic bullet that made this fortune and fame possible? Narcan. Add some, make money.
Suboxone; how a Big Pharma company reversed 80 years of American narcotics policy, the first bargaining chip at the peace table of the War On Doctors started in the '20s after the Supreme Court ruled on how to enforce the Harrison Act (by locking up doctors who prescribe narcotics addicts narcotics).
And how did they manage to take that giant step against the American Opiophobia? Put some Narcan in it.
Seriously. It worked for T's & Blues, remember? See, Pentazocine, Buprenorphine, both partial agonists, both have a long history of IV abuse and addiction, Naloxone cured the IV Talwin problem, we will prevent IV abuse of our Buprenorphine product from ever starting by putting the Narcan in first.
Sealed the deal; the FDA bought it. Only, no one ever thought to do bioassay tests on actual addicts, or run a trial on the drug use and abuse habits of sublingual Buprenorphine/Naloxone maintained patients (Come on, honestly, I know I'm not the only Suboxone patient who shot up his pills when everyone said the Naloxone would definitly cause precipitated withdrawals).
Doesn't matter though, Buprenorphine/Naloxone, the holy grail the drug warriors and drug czars of old were searching for, Suboxone, isn't half the myth they make it out to be.
But we forget the most important thing: it made Reckitt-Benckiser a mint. Europe had already accepted Buprenex, Subutex was just as readily jumped on without a hitch. Huge junk addict market in Europe to pry on, they didn't need the US and the rest of the world to make all that cash. But they did it anyway, Suboxone opened that door, and following suit parts of Asia followed us into Suboxone prescription maintenance (ask India and Bangladesh how well thats going now).
Anyway, thats the lead-up. Heres the point of the story:
Now that two working examples of narcotic/Narcan combination products are slick deal-makers in the American Big Pharma, Federal agency shakedown game, every other mom & pop pharmaceutical company is jumping on board with a Dope/Narcan product:
And they are getting approved! And funding! With excellent sales and profits projections!
The proof:
OXYTREK
While not Naloxone, it's still an antagonist, Naltrexone. Brought to us soon by Pain Therapeutics.
Oxycodone + Naltrexone in a pain relief pill.
Meaning: "We're gonna make a ton of fucking money duping the government, the patients and the addicts"
The bells tolls already for OxyTrek:
Straight from the studies mouth, my moneys on results from this abuse liability tests putting OxyTrek well below likability for plain Oxycodone, in those w/o a history of opioid abuse and those with a history of opioid abuse.
Less abusable, less desirable, cause they put the antagonist in it. See? Easy. $$$
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00734461
Number 2:
EMBEDA
Morphine + an antagonist (which one is not known yet)
This is a juicy story.
Same old story, add antagonist, dope not so good to dope fiends, no addiction, better pain management results in old people, etc etc etc
BUT- in the same breathe that they ask for funding:
I don't think I need to add the Pharmaceutical/Industrial Complex commentary on that one. Same story as Suboxone, Talwin NX and soon OxyTrek: Make a mint with a new medication to brand and have exclusive patent rights to, get great publicity and approval from the gov't / medical authorities for making a less addictive, less abusable, abuse-resistant, etc product. Stock manipulation by slightly altering the best selling product, create a competitor for your own product, make more money on your products by making more money on your products- a brilliant plan.
So, thats it people. First a trickle, here comes the flood.
Combination Agonist + Antagonist opioid medications are the future, thanks to Big Pharma and the crooked insider-trading-esque laws we have regarding pharmaceutical branding, patents and distribution rights.
Don't worry though, as with every other "less addictive", "tamper-proof" pill they make, we will all still be able to abuse, shoot, snort, parachute, plug, smoke, and combine these new and yet to be developed pills and formulations.
After all, they're counting on it, all the way to the fucking bank.
All for naught, as well. All for fucking naught.
It all started with Talwin; a few low-level healthcare workers came up with the T's & Blues combination, and shooting Pentazocine (which was unscheduled at the time) and Pyribenzamine (a.k.a. Tripellenamine, a common Rx cold/flu anti-Histamine of the day) spread across the country.
Then it started: Talwin NX. Pentazocine and Naloxone, combined in one pill. To stop intravenous abuse, they said. And it did: only, abuse never stopped, it just switched to oral and insufflation. A new combination was then discovered to be adequately euphoric to abuse: Talwin NX and Ritalin.
All was quiet for a couple decades, then Reckitt-Benckiser hit the lottery with their orphan drug Buprenorphine, owning the patents and branding rights for all of the Bupe products. The magic bullet that made this fortune and fame possible? Narcan. Add some, make money.
Suboxone; how a Big Pharma company reversed 80 years of American narcotics policy, the first bargaining chip at the peace table of the War On Doctors started in the '20s after the Supreme Court ruled on how to enforce the Harrison Act (by locking up doctors who prescribe narcotics addicts narcotics).
And how did they manage to take that giant step against the American Opiophobia? Put some Narcan in it.
Seriously. It worked for T's & Blues, remember? See, Pentazocine, Buprenorphine, both partial agonists, both have a long history of IV abuse and addiction, Naloxone cured the IV Talwin problem, we will prevent IV abuse of our Buprenorphine product from ever starting by putting the Narcan in first.
Sealed the deal; the FDA bought it. Only, no one ever thought to do bioassay tests on actual addicts, or run a trial on the drug use and abuse habits of sublingual Buprenorphine/Naloxone maintained patients (Come on, honestly, I know I'm not the only Suboxone patient who shot up his pills when everyone said the Naloxone would definitly cause precipitated withdrawals).
Doesn't matter though, Buprenorphine/Naloxone, the holy grail the drug warriors and drug czars of old were searching for, Suboxone, isn't half the myth they make it out to be.
But we forget the most important thing: it made Reckitt-Benckiser a mint. Europe had already accepted Buprenex, Subutex was just as readily jumped on without a hitch. Huge junk addict market in Europe to pry on, they didn't need the US and the rest of the world to make all that cash. But they did it anyway, Suboxone opened that door, and following suit parts of Asia followed us into Suboxone prescription maintenance (ask India and Bangladesh how well thats going now).
Anyway, thats the lead-up. Heres the point of the story:
Now that two working examples of narcotic/Narcan combination products are slick deal-makers in the American Big Pharma, Federal agency shakedown game, every other mom & pop pharmaceutical company is jumping on board with a Dope/Narcan product:
And they are getting approved! And funding! With excellent sales and profits projections!
The proof:
OXYTREK
While not Naloxone, it's still an antagonist, Naltrexone. Brought to us soon by Pain Therapeutics.
Oxycodone + Naltrexone in a pain relief pill.
Meaning: "We're gonna make a ton of fucking money duping the government, the patients and the addicts"
The bells tolls already for OxyTrek:
Straight from the studies mouth, my moneys on results from this abuse liability tests putting OxyTrek well below likability for plain Oxycodone, in those w/o a history of opioid abuse and those with a history of opioid abuse.
Less abusable, less desirable, cause they put the antagonist in it. See? Easy. $$$
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00734461
Number 2:
EMBEDA
Morphine + an antagonist (which one is not known yet)
This is a juicy story.
Same old story, add antagonist, dope not so good to dope fiends, no addiction, better pain management results in old people, etc etc etc
BUT- in the same breathe that they ask for funding:
I don't think I need to add the Pharmaceutical/Industrial Complex commentary on that one. Same story as Suboxone, Talwin NX and soon OxyTrek: Make a mint with a new medication to brand and have exclusive patent rights to, get great publicity and approval from the gov't / medical authorities for making a less addictive, less abusable, abuse-resistant, etc product. Stock manipulation by slightly altering the best selling product, create a competitor for your own product, make more money on your products by making more money on your products- a brilliant plan.
So, thats it people. First a trickle, here comes the flood.
Combination Agonist + Antagonist opioid medications are the future, thanks to Big Pharma and the crooked insider-trading-esque laws we have regarding pharmaceutical branding, patents and distribution rights.
Don't worry though, as with every other "less addictive", "tamper-proof" pill they make, we will all still be able to abuse, shoot, snort, parachute, plug, smoke, and combine these new and yet to be developed pills and formulations.
After all, they're counting on it, all the way to the fucking bank.
