RCs MPPP/Ro 2-0718

[muie]

Drugs like MPPP/Ro 2-0718 and PEPAP have been appearing recently on the lists of vendors alongside with U47700 and others. I am not aware if everybody is aware of the dangers associated with these substances.

How many people have encountered these two substance MPPP and PEPAP?

Chemically & structurally similar, they are both derivatives of pethidine/meperidine (Demerol). They are relatively easy to synthesize, and this was one of the principal reasons these particular substances were chosen for synthesis.

MPPP has about 70% of the potency of morphine. The potential for problems is when the reaction temperature raises above 30 °C, in which case an extremely toxic impurity is created called MPTP.

- “a common impurity in the synthesis of MPPP called MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that specifically targets dopamine producing neurons”

- “1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible symptoms similar to Parkinson's disease. MPTP is metabolized to the neurotoxin MPP+ by the enzyme MAO-B, which is expressed in glial cells. This selectively kills brain tissue in the area of the brain called the substantia nigra and causes permanent Parkinson symptoms”

“The intermediate tertiary alcohol is liable to dehydration in acidic conditions if the reaction temperature rises above 30 °C. Kidston did not realize this and esterified the intermediate with propionic anhydride at an elevated temperature. Consequently, MPTP was formed as a major impurity”.

“1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible symptoms similar to Parkinson's disease. MPTP is metabolized to the neurotoxin MPP+ by the enzyme MAO-B, which is expressed in glial cells. This selectively kills brain tissue in the area of the brain called the substantia nigra and causes permanent Parkinson symptoms.”

In comes PEPAP (phenethylphenylacetoxypiperidine). Due to the bad publicity of MPPP a very similar drug was created, almost a replica of the original chemical structure. PEPAP was reportedly 6-7 times more potent than morphine (in rats).

- “It is unlikely that the tetrahydropyridine byproducts that may be formed during the synthesis of PEPAP are neurotoxic in the same way as the MPPP byproduct MPTP”
- “It appears that the N-methyl group of MPTP is required for neurotoxic activity.”
- “Most structural changes, including replacing the N-methyl group with other substituents, abolished neurotoxicity”
- “There is evidence that the clandestine manufacturers who produced MPPP in the 1970s (included the tainted batch) went on to produce PEPAP in an attempt to avoid using watched precursors or drug intermediates that were illegal.”

 

[Tryptamite]

Interesting is this available on the clearnet or the dark Web I wonder if these compounds are banned in China or other manufacturers in Asia

I would be wary of m ppp simply because of the scandal with mptp in the 80s

Still though nice to see a change in direction from fentanyl analogues and more variety in the research chemical opioid scene

Does anybody have any first-hand accounts or links to forums with experienced users

 

[kleinerkiffer]

I found this for MPPP http://www.eve-rave.ch/Forum/viewtopic.php?f=37&t=13472&start=30

SWIN hat es nach Auschluß der Neurotoxischen Nebenprodukten ausprobiert.
Test ist über 5 Tage her und alles ist wie davor (also keine gravierende Nebenwirkungen).
Allerdings ist der Vergleich mit H ein Witz, ist genauso wie wie wenn man unter 5 % Reinheit Amphe mit 4-MMC vergleichen wurde.
Hoffentlich konnte damit die Substanz entmythfiziert worden und niemand ist mehr interessiert daran.
Der Vendor lässt sich von jedem Batch eine Analyse einschicken, die er auch hochladen kann. Hätte mich auch gewundert wenn die so ein Risiko auf sich nehmen wegen EINER Substanz.
AH 7921 hat im übrigen die selbe Potenz hat und wie ich mir habe sagen lassen wirkt sie deutlich besser.
O-DT war auch deutlich euphorischer wie SWIM berichtete.
Es lag auch nicht an zu niedrigen Dosen, 1g wurde ein einer Nacht vernichtet.
Nasal, oral, whatever außer gerauvht und iv. wurde alles getestet.
Sehr langweilig.
Noch etwas, nur weil es bei SWIM gut ging, heißt es noch lange nicht, dass es jedes mal so läuft.
Weiß vom Vendor, dass sie immmer sehr kleine Batches bestellen, von daher ist es auch schwer vom Einkaufsdatum auf den Batch zu schließen.
Mein Tipp:
Finger weg!
Total uninteressant, dazu noch gefährlicher als andere RC's!

To sum it up he took around 1g in a sitting and it's shitty. Comparing it to heroin is like comparing 5% amphetamine with 4-MMC.
AH 7921 seems to be equipotent but better and O-Desmethyltramadol is way better than MPPP




Really interessting https://erowid.org/archive/rhodium/chemistry/mptp.serendipity.html

https://erowid.org/chemicals/mptp/mptp_info1.shtml

MPTP, a pro-toxin formed in impure preparations of meperidine (Demerol), when injected intravenously in gram quantities, enters the brain. It is converted to MPP+ by monoamine oxidase B (MAO-B) in astrocytes. This toxin enters dopaminergic nerve terminals and is then concentrated in mitochondria, where it inhibits Complex I of the oxidative phosphorylation cascade. This action is associated with reduced ATP formation, as well as with the formation of free radicals. Eventually, the mitochondrial permeability transition pore's electrochemical gradient is abolished and apoptosis (programmed cell death) is induced. MPP+'s action is blocked by MAO-B inhibitors (e.g., selegilene), nitric oxide synthase inhibitors (reducing the peroxynitrite radical), and by salicylates (inhibiting a variety of free radicals), suggesting the involvement of these biochemical pathways in the pathogenesis of cell death.

MPTP parkinsonism produces a clinical phenocopy of PD, though, pathologically, it destroys nigrostriatal neurons throughout the nigra indiscriminantly, and typical Lewy bodies are not produced. Nonetheless, it is the best model of PD to date, and a great deal has been learned from it, in no small measure because of similarities of its neurochemical pathology with that of PD.

MPTP parkinsonism produces a mitochondriopathy (Complex I deficiency), placing the neurochemical pathology at the crossroads of the phases of commitment and execution of apoptosis. Recall that there are triggering factors of apoptosis (e.g., DNA damage, cell cycle perturbations, metabolic-toxic insults, growth factor deprivation), commitment factors (chiefly associated with the BCL-2 system), and an execution phase, associated with caspase activation. Despite these intriguing issues, there are conflicting studies regarding whether apoptosis is present in PD brain postmortem, and larger studies using carefully defined criteria will be necessary to settle the question.