I figured I'd post my experience with Mexedrone here because, despite being old and no longer relevant, I have some I bought a few years back and this thread is still the closest thing to reliable information I could find on it. So for anyone who still has any of the stuff lying around or comes across it...
Firstly, hard facts and science:
1. The stuff (bought from a now defunct RC vendor a few years back) is labelled as
3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one and the chemical structure posted in post #110 appears to be accurate (in that it matches what's printed on this bag).
2. The stuff's most definitely not inactive, despite many claims to the contrary. Scientific studies have been done that show it has pharmacological activity consistent with subjective reports here and elsewhere
[NCBI].
3. It
is a mephedrone derivative, with the addition of a methoxy group to position 3 in the propan-1-one sequence.
4. Mexedrone has an N-methoxy positional isomer,
N-methoxymephedrone, which far closer resembles mephedrone in terms of pharmacological activity, but the synthesis process yields actual mephedrone as a by-product impurity which causes legal problems. Speculation: It's possible earlier "samples" might have been this stuff, which is about 1/6th as potent as mephedrone and contains 6% actual mephedrone.
4. Mexedrone acts
only as a serotonin releasing agent, and does not cause dopamine or norepinephrine release, unlike mephedrone which releases dopamine, norepinephrine
and serotonin. However even this serotonergic effect requires 15x higher concentrations than mephedrone.
5. Mephedrone and mexedrone both act as dopamine, norepinephrine, and serotonin reuptake inhibitors, however mexedrone is between 7x and 18x weaker in this regard.
The tl;dr of mexedrone's pharmacology is that like mephedrone it works as a dopamine, norepinephrine and serotonin reuptake inhibitor, but unlike mephedrone, it only releases serotonin and not norepinephrine or dopamine.
It's also it's around 15x weaker in every respect. This would seem consistent with the numerous reports from users in this thread and elsewhere who have taken the stuff and experienced
some effect, as well as the high doses required.
Now for my personal experience with the stuff:
I'm not an avid sniffer of drugs so I took the stuff orally, 100mg, 50mg, and 250mg some time apart. The stuff I have is a slightly off-white/pale yellow crystalline powder.
I experienced a definite calm euphoria, starting about 15 minutes after ingestion and peaking between 20-25 minutes. The strength of the effect didn't seem particularly dose dependent, but rather the duration did seem to be. At 100mg, the effects mostly wore off around 30 minutes after ingestion (5-10 minutes after peaking), at 250mg they lasted until about 45-50 minutes (20-25 minutes after peaking).
As others have described, there's no real "stimulant" effect, and while I've no experience of mephedrone or other stimulants, it's definitely not as stimulating or energizing as the likes of even a low dose of LSD or ketamine. Rather, it just makes you happy and calm. I didn't notice any real side effects or after effects - some mild tachycardia (40bpm over resting) - so this stuff would actually be quite nice if it lasted longer and at lower doses.
All the above is pretty consistent with mexedrone's scientifically studied pharmacology - it's pretty much just a weak, short-lived serotonergic euphoriant that you have to take a ton of to get any effect. That's also consistent with the few people who took 1.0-1.5g of the stuff before it "worked", as well as the numerous people who noticed few to no effects - it's so weak and short lived I'm not surprised tons of people said it was a dud. It's fifteen times weaker than mephedrone and has no stimulant effects (biochemical or subjective) and at "normal" doses of a few hundred milligrams only lasts a few minutes - and that's in someone with no previous use of stims or tolerance.
Disclaimer: I'm only taking the stuff to try it out because I couldn't find any consistent info on it and just happened to have it lying around. I'm glad I don't remember how much I paid for the stuff... However, weak and short-lived as it may be, it definitely has
some effect and isn't totally inactive as some claim. Double disclaimer: pharmacological data taken from experiments on rat brains and may differ from humans, but seem pretty consistent with most actual user reports.
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
