Stimulants metoclopramide with amphetamine

[Ne0]

I took 10mg metoclopramide in the morning for nausea and after that amphetamine. So I wanted to be sure it's safe mix, I came up with this https://www.ncbi.nlm.nih.gov/pubmed/3615538 and https://www.ncbi.nlm.nih.gov/pubmed/4039669. "Metoclopramide potentiates d-amphetamine-induced hypermotility and stereotypy in rat.", so what it means, will it intensify or decrease the nice effects of amphetamine? normally i think neuroleptic would prevent the effects of amphetamine, but I still got nice euphoria out of my dosed amphetamine.

I didn't really know that metoclopramide is "classical neuroleptic" and is D2 antagonist. Never thought that anti-nausea medicine have anything do to with dopamine.

 

[Kittycat5]

The dopamine receptors where metoclopramide exerts its antiemetic action are in an area of the brain called the chemoreceptor trigger zone. Blockade of D2 receptors here decrease vomitting through a couple of mechanisms. It does block D2 in other areas as well but was never really used as an antipsychotic. If you took one dose of it, I think you will be ok.

 

[Ne0]

The dopamine receptors where metoclopramide exerts its antiemetic action are in an area of the brain called the chemoreceptor trigger zone. Blockade of D2 receptors here decrease vomitting through a couple of mechanisms. It does block D2 in other areas as well but was never really used as an antipsychotic. If you took one dose of it, I think you will be ok.

Ok good to hear. But i think it raised my blood-pressure and hear rate. Or might be the quetapien that I took last night on speed?

 

[Scrofula]

Those papers contradict each other, and I'm gonna venture it might have to do with measuring stereotypy in rats. I can't access the papers, but it sounds like a pretty loose assay. Watch the rats for 3 hours with a five-point clicker for every head twitch, gnaw, tail rear etc.? Are those standard measures? One lab does head twitch to the left, the other does head twitch to the right . . . .

If you expand the search to neuroleptics/anti-psychotics in general v. amphetamines, you find this review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898838/ that seems to say, "it's complicated", from a safety perspective.

I can see how blocking just the D2 action of amphetamine could still give you a standard high, just maybe minus the psychotic part? If it worked, that could be handy, in preventing both meth nausea and meth bad trips. But neuroleptics have such bad side effect profiles, I don't think it would be worth it. Metoclopramide has all kinds of warnings about the risk of movement disorders, I'd probably prefer to just barf all morning (did it for years anyway).

I think a bigger question is, do you really need an antipsychotic to handle your morning sickness? Why not ondansetron? Both have HT3 action. Either way, the two are probably "safe" in that you won't acutely die. But I'd look for something different.


ETA: wait, what? You're taking quetiapine too? Another D2 antagonist? Amd D1? And alpha? THat should interfere with your amphs. Why don't you use that for morning sickness?

 

[Ne0]

Those papers contradict each other, and I'm gonna venture it might have to do with measuring stereotypy in rats. I can't access the papers, but it sounds like a pretty loose assay. Watch the rats for 3 hours with a five-point clicker for every head twitch, gnaw, tail rear etc.? Are those standard measures? One lab does head twitch to the left, the other does head twitch to the right . . . .

If you expand the search to neuroleptics/anti-psychotics in general v. amphetamines, you find this review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898838/ that seems to say, "it's complicated", from a safety perspective.

I can see how blocking just the D2 action of amphetamine could still give you a standard high, just maybe minus the psychotic part? If it worked, that could be handy, in preventing both meth nausea and meth bad trips. But neuroleptics have such bad side effect profiles, I don't think it would be worth it. Metoclopramide has all kinds of warnings about the risk of movement disorders, I'd probably prefer to just barf all morning (did it for years anyway).

I think a bigger question is, do you really need an antipsychotic to handle your morning sickness? Why not ondansetron? Both have HT3 action. Either way, the two are probably "safe" in that you won't acutely die. But I'd look for something different.


ETA: wait, what? You're taking quetiapine too? Another D2 antagonist? Amd D1? And alpha? THat should interfere with your amphs. Why don't you use that for morning sickness?

I take quetiapine to get to sleep while doing amphs. Dosage 200mg. I never have noticed it decreases the effects of amphetamines next day as I always use it to get sleep when doing amphs (usually for 4 days binge). Metoclopramide is only anti-nausea medicine I can get and it's really good for it, never had a nausea that bad that it wouldn't take away, you need prescription for it. OTC-nausea treatment medicine are anti-histamines that would not help with normal nausea and don't mix well with stimulants anyway.

Not going to redose today, so I think I'm safe. Not wanting to take pregabalin as I want to take a break from it to lower the tolerance (only 3 days break will do the trick).

 

[Scrofula]

Metoclopromide and quetiapine work the same way for treating nausea. Both block D2 and HT3. No reason to take them together. Quetiapine would dampen amph effects, and is also a major anti-histamine for nausea.

Really, it's about why you need a drug given to chemo patients to handle nausea. I mean, why not, except these are all interacting with each other, and by themselves have risks. OTC anti-histamines work just fine on "normal" nausea, in fact better for it.

 

[Ne0]

Fuck haven't hit even 24h wake up yet but already saw some strange things on door like moving dots and other strange hallucinations and on my side-sigh see black things moving sometimes, can't be a good sign, so I took 20mg metoclopromide as it should take any psychotic/hallucinatory side-effects off at least I hope so. so lets see... I report back in 1 hour. Fucking meth why it has to be mixed with regular amphetamine, I waited sleep for hours took even 250mg qutiapine, couldn't sleep for 18h after last dose, so it was morning again and I can't break my sleeping cycle by going sleep at morning and wake up at noon, so need to go through this day, 10 more hours then I can hit to bed. This time sleep should come.

Any advices, should I take also 25mg quetiapine, can't hurt me right? Also going to take 300mg more pregabalin at some point, already took at the morning 300mg and it helped with my BP and HRB.

I have to watch porn to distract myself from seeing some strange moving things.

 

[Ne0]

It seems it completely killed hallucinations, but also took the good edge of from high, so need to redose.

 

[CFC]

Regardless of what it says it does to lab rats, metoclopramide brings me down nicely and I occasionally use it as part of my package of meds to kill meth/amps when I want to get back to normal.

 

[Ne0]

Regardless of what it says it does to lab rats, metoclopramide brings me down nicely and I occasionally use it as part of my package of meds to kill meth/amps when I want to get back to normal.

Nice to know I also recognized these effects, it made little sedate too. But you sitll can take amphetamines on top of metoclopramide.

 

[CFC]

Sure, with enough of anything one will usually win out over the other. But it's not really ideal to mix fundamentally contradictory meds on a regular basis - untoward outcomes can occasionally occur and it will force you to use more, which is generally more harmful.

 

[Ne0]

Sure, with enough of anything one will usually win out over the other. But it's not really ideal to mix fundamentally contradictory meds on a regular basis - untoward outcomes can occasionally occur and it will force you to use more, which is generally more harmful.

Yeah true, but if you didn't catch you're last night sleep it's nice to have metoclopramide just in case if anything strange start to happen. Not very harm reduction when still continuing take amphetamines after that, but well...

BTW. What dose you use and when is last amphetamine dose taken when you take it? Could be good to know in future, because it's seems better for this than quetiapine, as there can be sometimes trouble when taking quetiapine on speed, but metoclopramide does not to seem that kind of contraindications, so its safer for sure, even when taken just after dosing amphetamines. I took 20mg when I started to get hallucinations, they disappeared in 30 min. Also noticed that got sleepy and sedated, could be pregabalin too that I took at the morning.

 

[samm2]

The dopamine receptors where metoclopramide exerts its antiemetic action are in an area of the brain called the chemoreceptor trigger zone. Blockade of D2 receptors here decrease vomitting through a couple of mechanisms. It does block D2 in other areas as well but was never really used as an antipsychotic. If you took one dose of it, I think you will be ok.

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if you don't mind otherwise no bigg deal