Will do. Just worried about overdosing ... but I've read articles and have only heard of people becoming restless and agitated after taking meto. Couldn't find much about combining the two. Also, is 10mg of meto a low dose? That's what I was prescribed.
Metoclopramide is a dopamine receptor antagonist; most members of this class of drugs are used as antipsychotics, and metoclopramide shares many of their side effects, which is why it should not be used at high doses for extended periods of time. Psychiatrists now prefer to prescribe "atypical" antipsychotics like Quetiapine which are more selective for serotonin over dopamine, as these can be taken at higher doses before intolerable or dangerous side effects appear; likewise, ondansetron is often prescribed instead of meto for nausea for this reason.
Just a quick explanation of some of the side effects that have already been mentioned:
* "Motor dysfunction": When dopaminergic neurons die off, you get Parkinson's. When too many of them are blocked by a dopamine antagonist, you (temporarily) start exhibiting parkinson-like symptoms.
* anhedonia: blocking too many dopaminergic neurons leads to a decreased ability to experience pleasure
* restlessness: "Akathisia", an intense feeling of discomfort when sitting still. Another side-effect commonly associated with high doses of old-school antipsychotics
Now, if it's just occasional bouts of nausea and you don't exceed the prescribed dosage, metoclopramide is pretty well tolerated. But use it too often and above the prescribed dose, and you might do permanent damage to your dopamine system.
Under no circumstances should you attempt to use it on a regular basis to counteract the nausea or potentiate the "nod" induced by the recreational use of opioids.
