So for around the last year or so SWIM has taken MPA both recreationally and to study. Not hugely regularly, in the few days leading up to deadlines and occasionally on nights out, so approximately once to twice a month, but usually in large doses up to 150mg over the course of the day/night. However, SWIM also has done MDMA a few times over this period also, usually around once every month or two, and the last few times, probably for the past 6 months or so has noticed that their rolls are much more relaxed and give nowhere near the energy that they used to. After doing some more research on MPA and its cross tolerance, SWIM has realised MPA is much closer to Methamphetamine than they realised and Methamphetamine does have something of a cross tolerance with MDMA, something SWIM also didnt realise. Is it reasonable to assume that: a) SWIMS tolerance to Methamphetamines and therefore MDMA would have gone up, and b) That this is why SWIMs rolls on MDMA have been worse as of late? If so, how long would it take for this tolerance to drop again?
RCs Methiopropamine (MPA) and MDMA cross tolerance
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