^What was the concentration of that injection of 380mg? How much liquid had to be used?
I think it is important to note that people who IV methadone should not do so for higher bioavailability, as oral rates are close to optimal (up to 100%, but check the bio-availability info available elsewhere on the board). It is abusing prescribed methadone tablets, if one makes solutions from the tablets for injection, optimally by dissolving in bacteriostatic H2O meant for injection preperations, and subsequently micron filtering. And most methadone tablets I know of have so much chalk and talc in them, that it is a bitch to filter - speaking from personal experience here... I had marks from the plungers flat end for about an hour after micron filter some methadone tablets (had to use 3x 0.20 micron filters Ø=25mm for three 20 mg tablets, and it was still a bitch, the fillers clog the filters in no time).
However, I came across some 'Alternova Methadone HCl 20 mg' tablets marked 'M20' which contained very little binders, and the pills were about 1/10 the size of the usual 20 mg tablets available where I am. These 'M20's' produced the same rush and effects as the other tablets when I filtered and IV'ed them, but had the advantage that they were MUCH easier to micron filter. So I stocked a little up on those and had my fair share of fun filtering and IV administering methadone :D
With that said, I was abusing the methadone that I administered IV, although it was not prescribed (I obtained the various tablets elsewhere). I just deviated from my treatment with buprenorphine, and had a good a- musing/busing time for a couple of weeks.
And I agree with what was previously mentioned, that the IV ampules are near impossible to get. Nonetheless, there are solutions floating around here and there that are not sweetened or anything, which are basically a low-concentration oral solution of Methadone HCl in bacteriostatic H2O, meant for ingesting mixed with juice or something. But the concentrations in these solutions is very low (~1mg/ml), and would require evaporating the majority of the water, and essentially micron filtering to be extra safe, ridding the final solution of bacteria, for example. IV'ing a solution of the likes mentioned as is would require a A) very low to no tolerance, or B) injecting a whooping shitload of liquid if one has tolerance. Since Methadone HCl is caustic to the veins
(citation needed - help anyone?), injecting concentrated solutions is also not too good a thing to do.
I have not had experience doing any of the above, only micron filtering semi-concentrated solutions from tablets and IV administering the resulting solution, but I have heard rumours that people either boil down the aforementioned solutions and IV administer it, or just inject as is, depending on tolerance levels, and how much harm they are willing to do to themselves. Some people have an impressive 'don't give a shit' attitude towards their body, once they get hooked on IV'ing opiates - I really don't understand why some people don't care about the harm that is being done, essentially failing to acknowledge it at all in certain cases. But then again, people come from different backgrounds, and everyone has their reasons for their eventual mental and physical decay.
Once again, oral solutions are generally not ever designed to be injected, and most times, with substances of this nature, the producers tend to make the medicine preparations with certain contents that are there to inhibit abuse, e.g. IV'ing a solution meant for oral administration. And this goes for pretty much all medicine, whether tablets, filled gel caps, oral or IV solution, etc., preparations are made with A) maximum profit through medicinal value and potential as a main factor, while bearing in mind B) harm-reduction and low abuse potential, of course depending on what type of medication is being produced. For example, producers of Suboxone thought the naloxone would prevent IV abuse, and thus be a way out of both opiate abuse and needle fixation for a near-doomed but help-hunting IV'ing junkie (that was an extreme example, so bear in mind that people go into buprenorphine/methadone ORT with much lesser abuse patterns, including myself)... but what do you know, an IV junkie always finds his/her way.
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-bwanajzj
