• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • Bluelight HOT THREADS
  • Let's Welcome Our NEW MEMBERS!

Opioids Methadone 5 mg every 48 hrs. Minimal dependency. Can i do bupe w/o precip. Wd?

LucidSDreamr

Bluelighter
Joined
May 23, 2013
Messages
5,255
Location
Silicodone Valley
So I've only used methadone for 1 month. Was non dependent on opiates before then.

I take 5 mg every other say. I cam go 5 days clean with minimal WD (just sleep trouble) Would I be able to take bupe without going into precipitated withdrawal without waiting a long time post methadone dose?
 

negrogesic

Moderator: BDD, OD
Staff member
Joined
Jul 21, 2002
Messages
9,360
Location
Negronesia
Hard to say but I'd still wait at least a few days to attempt taking buprenorphine after taking even a small dose of methadone. Methadone withdrawal doesn't really get going until day 9. When I tapered from 380mg to 5mg and then cold turkeyed the withdrawal was surprisingly severe. Not worth the risk, wait.
 

LucidSDreamr

Bluelighter
Joined
May 23, 2013
Messages
5,255
Location
Silicodone Valley
Hard to say but I'd still wait at least a few days to attempt taking buprenorphine after taking even a small dose of methadone. Methadone withdrawal doesn't really get going until day 9. When I tapered from 380mg to 5mg and then cold turkeyed the withdrawal was surprisingly severe. Not worth the risk, wait.
But i was never that dependent I went from clean...to only 5 mg from naive.for a few weeks. Plus I just went 5 days clean last week with minimal withdrawal (only difficult sleeping on days 4 and 5)...I'll add that roughly 30 percent of my dose days were only 2.5 mg...
Not even 5 mg

Shouldn't precipitated WD only happen if I would have a normal WD if if cold turkeyed?...which I don't have st this time. stage.

I could switch to Norco for a few days then go to bupe (a transition I am well familiar with) but done to bupe is new territory.

I can tell you....before these few weeks on 5mg.dome every other day, I was getting waaay higher off 1 or 2 mg bupe than 5 mg done. (This was before the previous several week done use. I was sort of alternating between the two at that time but also taking 3 to 4 days off everything in-between. Albiet I hadn't had the 3 week regular 5 mg done every 48 hrs I have been doing latley. So I feel like I'd be higher of I switched...not in WD. But I'm well aware it's a sketchy transition make so that's why I ask.
 
Last edited:

DeathIndustrial88

Bluelighter
Joined
Jan 23, 2020
Messages
570
Location
The Land Of Nod
But i was never that dependent I went from clean...to only 5 mg from naive.for a few weeks. Plus I just went 5 days clean last week with minimal withdrawal (only difficult sleeping on days 4 and 5)...I'll add that roughly 30 percent of my dose days were only 2.5 mg...
Not even 5 mg

Shouldn't precipitated WD only happen if I would have a normal WD if if cold turkeyed?...which I don't have st this time. stage.

I could switch to Norco for a few days then go to bupe (a transition I am well familiar with) but done to bupe is new territory.

I can tell you....before these few weeks on 5mg.dome every other day, I was getting waaay higher off 1 or 2 mg bupe than 5 mg done. (This was before the previous several week done use. I was sort of alternating between the two at that time but also taking 3 to 4 days off everything in-between. Albiet I hadn't had the 3 week regular 5 mg done every 48 hrs I have been doing latley. So I feel like I'd be higher of I switched...not in WD. But I'm well aware it's a sketchy transition make so that's why I ask.
You actually might feel "higher" from the bupe. 5mg of methadone is pretty small. Although I've never been depedent on methadone, so I can't say.

Technically bupe is only a partial agonist, so you shouldn't feel higher but 5mg is such a low dose that it's hard to say. The equivalency charts use to list a couple mg of buprenorphine as having the same agonist activity as 30mg of methadone. So I guess it's not impossible.

I'd still follow negrogesic's advice and wait as long as you can and then try the bupe.
 

Sunyecho

Bluelighter
Joined
Jul 20, 2020
Messages
1,645
Location
Trying to find my self but unable so far.
I believe that DeathIndustrial is closer to the truth than negrogesic. Especially if you take a sufficient dose of buprenorphine. There may be some symptoms while methadone is being kicked off from receptors but as your dose of methadone is so small buprenorphine should overpower it in no time. That is my guess. I switched from 30mg methadone daily to buprenorphine with a 7 day morphine "bridge" and did not experience a bad transition. Had to endure some withdrawals from morphine but it wasn't that bad.

If you want to be sure that you don't experience anything negative and get high immediately (for a few days you will probably get high on buprenorphine until you adjust) then wait ~3 days with no methadone intake. But I think it is not necessary.

P.S. I am just giving you my opinion and this is your body, your decision and you will have to endure all the effects, good and bad ones. I hope you have a smooth transition.
 

DeathIndustrial88

Bluelighter
Joined
Jan 23, 2020
Messages
570
Location
The Land Of Nod
I agree with Psycho_Logic. Been on bupe for years.

When you do start on the bupe, start low too. Like 0.25mg or .5mg
Bupe is very potent and if you are looking for the 'high' effects, you'll get more out of it at these lower doses.
I've seen non tolerant people puke & nod for 6-12hrs off half a milligram of buprenorphine. It's ridiculously potent.
The higher dosages are for people coming off long term heroin/full agonist dependency.

These smaller doses also help lower your chance of being thrown into precipitated withdrawal. And if you do end up in PWD, you can still take methadone over these low doses and get a synergistic effect.

You can always increase the dose too if you don't feel anything. Bupe can take awhile to kick in though too.

I use to be able to mix small doses of bupe and heroin and they would actually potentiate each other to some degree, but I always used the full agonist AFTER I had taken the bupe.

So if you take a dose of bupe and feel like you're in withdrawal, you should be able to still pop a methadone and be covered. Just be very careful doing this!!!

Some people theorize that at low doses, bupe's metabolite, norbuprenorphine (which is a full agonist) has a chance to attach to receptors, but the consensuses on this is muddy and no one knows for sure if norbuprenorphine is active or not. Some research papers say it isn't and some say it is. Some say bupe has no respiratory depression effects at all, so any respiratory depression you get from it could be from norbuprenorphine. Maybe one day we'll know for sure if it's active or not.
 
Last edited:

SteeleyJ

Bluelighter
Joined
May 24, 2006
Messages
2,609
Location
We use our palm as a map.
I agree if you switch to bupe I would advise taking an 8mg sub and cutting 8 squares.... then cutting each of the squares into 3 pieces. That will be around .3mg. Should be plenty with the amount of methadone you are using. You can always go up of it doesn't work but If your goal is to find something comparable.... that is my advice.
 

LivingOnValium

Bluelighter
Joined
Aug 24, 2006
Messages
2,591
Location
Helsinki, Finland
I'm quite positive that if 5mg methadone will hold you from withdrawal for 48h you can successfully take buprenorphine without any shitty feelings. My expectation is that if you wait 48h after taking 5mg methadone and then take a dose buprenorphine (let's say 1mg) you will feel quite good and euphoric. Taken in consideration that your opiod tolerance is that low, 2mg of bupe might actually be too much for you and therefore could make you nauseous.

Edit: I read a few posts above myself and I'll have re-evaluate what i just said. If you happen to be hypersensiteve to buprenorphine 1mg is way too much to start with, unless 24h of binge vomiting sounds like a good time. I do think no one should take more than 0,5mg buprenorphine in a single dose unless being opioid tolerant.
 
Last edited:
Top