Addiction Meth

[mr peabody]

Welcome! Following is a DIGEST of articles and reports that is constantly updated. Jump in!

What is methamphetamine?

Methamphetamine is a dangerous and powerful chemical that first acts as a stimulant but then begins to systematically destroy the body. Meth releases high levels of dopamine when ingested and then blocks the normal flow of dopamine in the absence of the drug. These neurotransmitters involve the reward system that regulates pleasure, happiness, motivation, energy, and functional ability. Meth changes the way the brain functions; the brain becomes dependent on the drug to survive. Meth use deteriorates the body from the inside out, creating a devastating dependence that can only be relieved by taking more of the drug.

What is ibogaine?

Ibogaine is a powerful psychedelic from West Africa known for its miraculous ability to cure or drastically reduce meth addiction in a single treatment. It can also help people overcome addiction to prescription opiates such as morphine, methadone, Vicodin, Percocet, and OxyContin. While this may sound too good to be true, scores of personal testimonies and now clinical research is backing up this claim, and iboga treatment centers are popping up all over the world specializing in treating addiction, post traumatic stress, and mood disorders.

Ibogaine addiction recovery therapy

Treatment with Ibogaine offers an extremely high success rate for recovery from meth addiction. After treatment they hold a new vision for life that is full of possibility with no desire physically or psychologically to use the drug again.

Ibogaine works by resetting the neurotransmitters damaged by drug abuse. Treatment with Ibogaine will help one understand the reasons they have been led to addiction in the first place, and allow them to process these issues so that there is healing on a deep fundamental level.

Ibogaine is a psychedelic medicine found in the bark of an African shrub with strong anti-addictive qualities that will help you achieve your two most difficult goals.

1) Ibogaine can significantly reduce opiate/opioid withdrawal symptoms in under 24 hours.

2) Ibogaine eliminates the desire for opiates/opioids. Many people who have taken Ibogaine swear that it cured their addiction altogether.

Ibogaine treatment has a mortality rate of 1 in 300, with deaths coming from brachycardia (heart rate slowing way down) and lethal combinations with other drugs. The risks of this treatment should therefore be weighed very carefully, and flood treatment should only be done in a medical setting.

Doctors and treatment providers have found that small daily doses seem to work better for meth addiction than the mind-blowing "flood doses" used on opiate addicts.

Researcher Howard Lotsof, PhD, addicted to heroin and methadone, discovered the anti-addictive action of ibogaine in 1962. Given a capsule of pure ibogaine by a trusted friend, Lotsof was simply seeking a new high. He was astonished when coming out of this difficult experience 36-opiate-abstinent hours later to realize he had no physical craving for opiates and even more remarkably, very little of the agonizing physical symptoms normally associated with opiate withdrawal.

Ibogaine is not approved for any medical uses in the U.S., though it is used as an alternative medicine treatment for drug addiction in some countries. Its prohibition has slowed scientific research. The use of Ibogaine for drug treatment is now accepted in Canada (not), Mexico, France, and the UK. In many cases, administration of a therapeutic course of Ibogaine is followed by intensive counseling therapy. Often more than one round of the drug is needed for lasting sobriety.

CAUTIONARY GUIDELINES

People with any kind of heart conditions should not use ibogaine or iboga in any form.

People who have a bad reaction to the test dose should discontinue ibogaine treatment.

People who have any kind of liver conditions should not do ibogaine or iboga in any form.

People who are on any kind of medications which cause long QT syndrome for which ibogaine will make you temporarily sensitive should discontinue those meds unless necessary. If those meds are necessary they should not take iboga or ibogaine.

People who have found abnormalities on the EKG, stress test, or CBC/liver panel should not take ibogaine or iboga until if and when those conditions are resolved.

People on MAOIs, SSRIs, or any other psych meds should not take iboga or ibogaine until those meds have cleared the system, we recommend not stopping needed psych meds to take iboga. Some of these medications may potentiate iboga or lead to serotonin syndrome.

If you are currently addicted to benzodiazepines, barbiturates, GHB, GBL, 1,4-BDO, phenibut or alcohol, it is recommended you get through the acute withdrawals before taking ibogaine, as abruptly discontinuing those drugs may lead to seizures. Ibogaine will not eliminate the withdrawals from Gabaergic drugs although it can help with cravings. If you choose to ignore this recommendation then you must tell you treatment provider and your provider must have a Gabaergic drug on hand in case any seizures should happen.

Clinical Guidelines for Ibogaine-Assisted Detoxification - The Global Ibogaine Therapy Alliance

GITA's open source Clinical Guidelines document represents a consensus on medical risk-management for ibogaine-assisted detoxification.

www.ibogainealliance.org

 

[mr peabody]

Following are downloadable studies on the efficacy of ibogaine in the treatment of drug addiction.​

STUDY: A mixed-method analysis of persisting effects associated with positive outcomes following ibogaine detoxification - Davis, et al. - 2018​

STUDY: A phenomenological analysis of the subjective experience elicited by ibogaine in the context of a drug dependence treatment - Schenberg, et al. (2017)​

STUDY: A phenomenological investigation into the lived experience of ibogaine and its potential to treat opioid use disorders - Camlin, et al. - 2018​

PAPER: An end to the opioid epidemic: New study suggests ibogaine treatment could be a game changer - Garcia, Barsuglia (2017)​

PAPER: An ibogaine treatment protocol - Geerte for Lindesmith Centre​

THESIS: Breaking the habit: Ibogaine as a viable treatment for opioid dependence and withdrawal - Matthew Styles (2014)​

STUDY: Case studies of ibogaine treatment: Implications for patient management strategies - Lotsof, Alexander (2001)​

STUDY: Changes in withdrawal and craving scores in participants undergoing opioid detoxification utilizing Ibogaine - Malcolm, Polanco, Barsuglia - 2018​

STUDY: Clinical guidelines for ibogaine-assisted detoxification - Dickinson, McAlpin, Wilkins, Fitzsimmons, Guion, Paterson, Greene, Chaves (2016)​

STUDY: Detoxification from methadone using low, repeated, and increasing doses of ibogaine: A case report - Wilkins, et al. (2017)​

THESIS: Experiences of opioid detoxification using ibogaine in various treatment settings - Jamie Walker (2016)​

STUDY: Ibogaine and addiction in the animal model, a systematic review of and meta-analysis - Belgers, et al. (2016)​

STUDY: Ibogaine as a potential anti-addictive treatment - Nor Ilyani Mohamed Nazar (2014)​

STUDY: Ibogaine as an alternative and efficacious treatment for heroin addiction - Amadon, Roecker​

STUDY: Ibogaine detoxification transitions opioid and cocaine abusers between dependence and abstinence: Clinical observations and treatment - Mash, et al. - 2018​

STUDY: Ibogaine effect on cocaine craving and use in dependent patients: A double-blind, placebo-controlled pilot study - Pedro Luis Prior, Sergio Luiz Prior (2014)​

STUDY: Ibogaine for opioid use disorder: Can we root out addiction at its source? - Shuang Ouyang (2016)​

PAPER: Ibogaine in the treatment of chemical dependence disorders: Clinical perspectives - Howard Lotsof (1995)​

STUDY: Ibogaine in the treatment of heroin withdrawal - Mash, Kovera, Pablo (2001)​

STUDY: Ibogaine in the treatment of substance dependence - Thomas Kingsley Brown (2013)​

THESIS: Ibogaine offers an alternative approach for treating opiate addiction - Christopher Nielsen - 2018​

STUDY: Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study - Noller, Frampton, Yazar-Klosinski (2016)​

STUDY: Ibogaine: An anti-addictive drug: Pharmacology and time to go further in development - Maciulaitis, Kontrimaviciute, Bressolle, Briedis - 2008​

STUDY: Ibogaine: A novel anti-addictive compound - A comprehensive literature review - Freedlander, DiClemente (2003)​

STUDY: Ibogaine: A review - Kenneth Alper (2015)​

STUDY: Ibogaine: Treatment outcomes and observations - MAPS (2003)​

STUDY: Life after ibogaine: An exploratory study of the long-term effects of ibogaine treatment on drug addicts - Ehud Bastiaans (2004)​

STUDY: Mechanisms of action of ibogaine: Relevance to putative therapeutic effects and development of a safer iboga alkaloid congener - Glick, Maisonneuve, Szumlinski (2001)​

STUDY: Novel pharmacotherapeutic treatments for cocaine addiction - Daryl Shorter, Thomas Kosten (2011)​

STUDY: Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity - Sweetnam, et al. (1994)​

STUDY: Remission of severe opioid use disorder with ibogaine: A case report - Cloutier-Gill, Wood, Millar, Ferris, Socias (2016)​

STUDY: Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes - Davis, et al. (2017)​

STUDY: The antiaddictive effects of ibogaine: A systematic literature review of human studies - Dos Santos, Bouso, Hallak (2016)​

STUDY: The use of ibogaine in the treatment of addictions - Kenneth Alper, Howard Lotsof (2007)​

STUDY: Treating drug dependence with the aid of ibogaine: A qualitative study - Schenberg, de Castro Comis, Alexandre, Chaves, T́ogoli, Dartiu, da Silveira (2016)​

STUDY: Treating drug dependence with the aid of ibogaine: A retrospective study - Schenberg, de Castro Comis, Chaves, da Silveira (2014)​

STUDY: Treatment of acute opioid withdrawal with ibogaine - Alper, Lotsof, Frenken, Luciano, Bastiaans (1999)​

STUDY: Treatment of opioid use disorder with ibogaine: Detoxification and drug use outcomes - Brown, Alper (2017)​

STUDY: Treatment of opioid use disorder with ibogaine_Detoxification and drug use outcomes: Clinical rationale - Brown, Alper (2017)​

 

[mr peabody]

Melinda McDowell sought treatment for her addiction to meth. She started taking
the medication naltrexone and has been sober for more than a year now.


A medication to treat meth addiction? Some are taking a new look at Naltrexone

by Andrea Dukakis | NPR | Nov 7 2019

Melinda McDowell had used drugs since she was a teenager. But she didn't try methamphetamine until one fateful night in 2017 after her mother died suddenly of a stroke. She went to a neighbor's house and he had crystal meth.

"I tried it and I was hooked from the first hit," McDowell says. "It was an explosion of the senses. It was the biggest high I'd ever experienced."

Afterward, McDowell says, that big high started getting more elusive. But she kept using the drug frequently, and it took a toll. She went from 240 pounds to 110. Eventually, she lost custody of her children, who were put in foster homes. McDowell started having hallucinations.

McDowell tried many times to stop using meth, but when she'd quit for a few days, she'd have severe panic attacks and begin to shake uncontrollably. One night, she remembers lying on her bathroom floor thinking that if she didn't get help, she'd die.

She heard about a woman named Nancy Beste who had recently opened the doors to a treatment center called Road to Recovery in Steamboat Springs, Colo., near where McDowell lived. McDowell says she begged Beste for help.

Beste, who's a certified addiction counselor and physician assistant, says McDowell's call came at a fortuitous time. She had just gotten back from a conference where she learned about research into what's called medication-assisted treatment, or MAT, for methamphetamine users. Some early studies indicate that naltrexone, the same medication used to treat alcohol addiction and opioids, can work for some people addicted to methamphetamine.

Beste gave McDowell a prescription for naltrexone and signed her up for individual and group therapy. McDowell says that three to four hours after she took the first pill, she felt better. After the second pill, the withdrawals lessened.

"The shaking started going away. I wasn't panicking. I could feel some relief," McDowell says. "I knew there was something different."

That was more than a year ago. McDowell is still sober today.

Nationally, methamphetamine use is soaring, especially in the West, and the treatment community is struggling to come up with the best ways to help.

Medication-assisted treatment with drugs such as methadone, buprenorphine and naltrexone are standard care for people addicted to opioids, but there are currently no FDA-approved medications for meth addiction. Still, a number of practitioners are beginning to experiment with treating meth use disorder with naltrexone — along with other medications like the antidepressant bupropion. And researchers are taking a look at naltrexone for meth, too, finding some promising initial results.

Dr. Keith Heinzerling, an addiction medicine specialist at the Pacific Neuroscience Institute in Santa Monica, Calif., says he prescribes naltrexone off-label, in combination with other medications, for methamphetamine addiction if patients are interested in trying it. And he believes, when combined with physician oversight and counseling, it can be an effective treatment.

"I think there's a great opportunity to try naltrexone," Heinzerling says. "There's actually a decent amount of evidence that it might help, and if I had a family member [addicted to meth], I would recommend they try it."

Heinzerling points to preliminary studies on naltrexone that support the idea that it might help reduce people's cravings for methamphetamine. Heinzerling believes naltrexone can have an anti-addiction effect for many drugs and potentially for other types of compulsive behaviors.

But, he cautions, much is still unknown, and more research on drugs like naltrexone for methamphetamine is needed.

Psychologist Lara Ray, a professor at the University of California, Los Angeles and head of the UCLA Addictions Lab, has done several studies on the effectiveness of naltrexone for methamphetamine addiction.

In one study, published in 2015 in Neuropsychopharmacology, volunteers who used methamphetamine were admitted for a four-day hospital stay. They were given either naltrexone or a placebo, and on the final day, an IV infusion of methamphetamine. The subjects were asked a series of questions, including how strong their cravings were.

"We found that naltrexone is better than a placebo at reducing the cravings for methamphetamine," Ray says.

A large, multisite study led by University of Texas Southwestern Medical Center looks at the effects of Vivitrol — a longer-acting, injected version of naltrexone — combined with bupropion. The study, a randomized, controlled trial, was recently completed and researchers are awaiting results.

Other researchers are trying to come up with new compounds to treat meth addiction. But Ray says there's a more immediate benefit to naltrexone and other drugs already available. She says that although the drugs lack FDA approval for use with methamphetamine addiction, practitioners can choose to prescribe them off-label.

"The good news is that these drugs have been on the market for a while, so we know what side effects there are and the cost-benefits," she says. "So, it's possible for providers to be making individual decisions for individual patients to educate [them] to consider off-label."

"Doctors should be aware that the literature is somewhat preliminary," she adds.

Ray says that if she had a family member with the disorder, she would want their treatment provider to experiment with drugs like naltrexone and Vivitrol "in combination with behavioral treatment."

Beste, who also treats patients with opioid addiction, says all of her patients have to do counseling in conjunction with medication-assisted treatment, and the goal is to eventually wean them off those medications. So far, Beste has tried naltrexone with about 16 patients who use meth. Of those, the drug appears to have helped reduce the cravings for methamphetamine in about half of them.

Melissa McDowell of Steamboat Springs says getting off meth has been arduous. But she credits naltrexone for helping her stay sober now for more than a year. It's an uphill battle. McDowell recently learned that the courts had denied her efforts to regain custody of her children.

But she's still pushing forward. McDowell is interviewing for jobs, and at some point, she wants to go to school so she can treat people like herself who want to break free of methamphetamine.

NPR Choice page

 

[mr peabody]

"I’ve seen things you people wouldn’t believe. Attack ships on fire off the shoulder of Orion.
I watched C-beams glitter in the dark near the Tannhäuser Gate. All those moments... will
be lost in time, like… tears in rain. Time to die."


Last month, dozens of ibogaine researchers, activists, and treatment providers gathered for a conference in Barcelona, where topics included safety and sustainable sourcing of ibogaine from Africa. Dr. Kenneth Alper was among the attendees who gave a presentation on the benefits of ibogaine to the Catalan Ministry of Health. The NYU prof believes ibogaine’s most likely path to prominence in the United States will be as a medication for meth addiction, for the simple reason that doctors and treatment providers have found that small daily—and thus drug-company-friendly—doses seem to work better formeth addiction than the mind-blowing “flood doses” used on opiate addicts.

Alper says "No one thought to try non-hallucinogenic quantities of ibogaine until recently." Ibogaine treatment providers tend to have been former ibogaine users, and most assumed that the introspection brought on by tripping was key to overcoming their addictions. “That’s just how it evolved,” he says, noting that the large doses do seem to work best for opiate detox. “You’re talking about a drug that has been used in less than 10,000 people in the world in terms of treatment. It’s not surprising that’s how it evolved.”

“The visions have some psychological content that is salient and meaningful,” Alper adds. “On the other hand, there is no successful treatment for addiction that’s not interpreted as a spiritual transformation by the people who use it. It’s the G-word. It’s God. We as physicians don’t venture into that territory, but most people do.”

-Keegan Hamilton

 

[mr peabody]

Naltrexone may be a promising treatment for addiction to methamphetamine

"The results were about as good as you could hope for," said Lara Ray, a UCLA associate professor of psychology, director of the UCLA Addictions Laboratory and lead author of the new study.

The study, published in the journal Neuropsychopharmacology, was the first in the U.S. to evaluate Naltrexone for treating methamphetamine addiction. Researchers analyzed 22 men and eight women who use methamphetamine an average of three to four days a week.

During a four-day hospital stay, each person was each given either Naltrexone -- 25 milligrams the first two days, 50 milligrams on days three and four -- or a placebo daily. Ten days later, the subjects were readmitted to the hospital for four more days; those who had taken Naltrexone earlier were given placebos, and vice versa.

On the last day of each hospital visit, all participants were given intravenous doses of methamphetamine. Three hours later, the researchers asked how they felt and how much they wanted more of the drug.

The scientists found that Naltrexone significantly reduced the subjects' craving for methamphetamine, and that it made them less aroused by methamphetamine: Subjects' heart rates and pulse readings both were significantly higher when they were given the placebo than when they took Naltrexone. In addition, participants taking Naltrexone had lower heart rates and pulses when they were presented with their drug paraphernalia than those who were given placebos.

Ray said the results indicated that Naltrexone reduced the rewarding effects of the drug -- those taking Naltrexone did not find methamphetamine to be as pleasurable and were much less likely to want more of it.

Naltrexone was well tolerated and had very minimal side effects. The researchers found that men and women both were helped by taking Naltrexone, although the positive effect on men was slightly smaller. It made no difference whether the participants were given Naltrexone during their first hospital stay or their second.

Naltrexone works by blocking opioid receptors in the brain. Ray said that in previous studies, people undergoing treatment for alcoholism reported getting less of a "high" from drinking when they take Naltrexone.

Ray, whose research team studies the causes of drug and alcohol addiction and possible treatments, plans to examine whether Naltrexone would be more effective in combination with other pharmaceuticals and at different doses. Her research is funded by the National Institute on Drug Abuse and UCLA's Clinical and Translational Science Institute.

Twenty-five of the participants also underwent functional magnetic resonance imaging, or fMRI, brain scans in UCLA's Center for Cognitive Neuroscience. Ray and UCLA graduate student Kelly Courtney, a co-author of the Neuropsychoparmacology paper, are analyzing that data.

Methamphetamine use disorder is a serious psychiatric condition that can cause psychosis and brain damage, and for which no FDA-approved medication exists. An estimated 12 million Americans have used methamphetamine, nearly 400,000 of whom are addicted to it, according to recent estimates.

Although the new study is promising, it needs to be backed up by clinical trials, said Ray, who is also a member of the UCLA Brain Research Institute. The next step in evaluating Naltrexone's effectiveness for treating people addicted to methamphetamine is already underway: the National Institute on Drug Abuse is sponsoring clinical trials.

-Science Daily

 

[mr peabody]

Ibogaine, drug to end all drugs

By Tristram Korten

On his 30th birthday, Patrick Kroupa was arrested for possession of heroin in Manhattan. “I turned 30 in the Tombs,” he says, referring to the notorious jail beneath the criminal courthouse. In the dank concrete cell, the magnitude of what he had lost overwhelmed him, and he resolved to quit.

It wouldn’t be his first effort. “I probably tried 18 to 20 medically supervised detox programs over the years, and maybe another 75 do-it-yourself attempts,” he says. Among the programs he tried: substitution therapies like methadone and buprenorphine, which replace heroin with a milder opiate; ultra-rapid detox, in which the addict is anesthetized to help with the withdrawal process; and a medical procedure using a TENS unit in which electrical currents stimulate the brain. But with each method, withdrawal was unavoidable, and Kroupa winces at the memories: “All of them just mean't pain, real pain.” And none of them worked.

Then he heard about a treatment center on the Caribbean island of St. Kitts. In October 1999 Kroupa rounded up the $10,000 necessary to enroll. When he first arrived, he was in the throes of withdrawal— cramping, cold sweats. “My spine felt like it was being crushed,” he recalls.

Kroupa’s treatment consisted of wearing a blindfold on a bed in a darkened room, listening to soothing music through earphones, and ingesting about 12 milligrams per kilogram of body weight of ibogaine hydrochloride in capsule form, all the while attached to a bank of machines that monitored his vital signs. “Within 30 to 35 minutes, this ball of heat went up my spine and the pain just let go,” Kroupa recounts. “Nothing has ever done that. It was like my habit was a bad dream, a mirage. And before I can focus on what just happened, I start tripping. Eight and a half hours later, they take the blinds off.”

Kroupa felt cured. He no longer craved heroin. But it didn’t change 16 years of behavioral patterns that led him to heroin in the first place. On his way back to the U.S., Kroupa’s plane stopped over in Puerto Rico, where he immediately copped a bag of heroin. A month later, strung out again, he returned to St. Kitts for another treatment. He’s been clean ever since.

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While ibogaine may be effective for withdrawal from recreational opioid addiction, there are so many, because of chronic pain, who have no other options. Except now there is an alternative: Mitragyna Speciosa, aka Kratom. As far as I'm concerned this herb is a Godsend! It provides pain relief while subduing symptoms of withdrawal from opioids, even reportedly, heroin addiction.

DEA has threatened to make it a schedule 1 drug, but has put that move on hold due to public outcry and until further studies have been done. Currently it can still be purchased in 45 states that I know of. This may be something you might want to look into, if you haven't already.

-DylanCharles & Waking Times

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I had the pleasure of doing ibogaine to cure my addiction to crystal meth, and it worked! I’m 100% better. This stuff is a miracle. We need to legalize it. I feel like I never even used meth
and am therefore free from the feelings of needing it. God bless ibogaine.

-taija

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Doctors and treatment providers have found that small daily doses seem to work better for meth addiction than the mind-blowing "flood doses" used on opiate addicts.

 

[mr peabody]

Australian therapist calls on the government to research ibogaine for treatment of ice addiction

An alternative drug therapy provider has written to the Australian government calling for research into a controversial alternative treatment to combat ice addiction.

Hypnotherapist Vanessa Gregory said the Government's National Innovation and Science Agenda should be used to fund a drug trial of iboga and its chemical derivative, ibogaine.

"Ibogaine is a ceremonial drug that's been used for centuries that comes from the bark of a shrub ... that is found in West Africa," she said.

"What appears to happen after taking ibogaine: over a three day period they go into an internal experience, they appear to do a life review, and they appear to come out with no actual interest or need for illicit substances afterwards."

Ibogaine resets opioid receptors that flare during addiction

Dr Stephen Bright, from the School of Psychology and Speech Pathology at Curtin University said research into ibogaine was needed to investigate the drug's potential.

"The interesting thing about ibogaine is that it tends to reset the opioid receptors sites so that the person, that may be heroin dependant or dependant on another opiate, doesn't really go through a withdrawal period and their tolerance to the drug is reduced as if they had never used before," Dr Bright said.

He said the potential benefit of ibogaine stems from its ability to inspire a period of self-reflection.

"An integral component of ibogaine is not just the fact that it resets the opiate receptor sites, but the way in which it forces the person to reflect on how their drug use has impacted on their family and their community," he said.

Dr Bright said, while there have been reports of deaths as a result of taking ibogaine, these interactions occurred in a non-clinical setting.

"The problem is that is has an impact on the cardiovascular system," he said.

Despite this, Dr Bright said the benefits outweigh the potential risk.

"If screening is conducted and we determine that the person doesn't have any pre-existing cardiovascular disorders, then it's unlikely to have a risk that would outweigh the benefit of potentially trialing it."

Government funding needed for research

"In the 60s, experimentation with iboga and ibogaine began in the US as a potential treatment for opiate addiction and it continues to be used in some countries like Mexico and Canada, where they administer the actual chemical contained in the plant in a controlled clinical setting."

But Dr Bright said there have not yet been any randomised trials of the drug, so research was needed to understand it.

"Ibogaine is actually a Schedule 4 drug in Australia, so it can be prescribed by a doctor," he said. "All that research would require is for somebody to apply for a research grant to conduct a randomized control trial of the trial, engage with a university pharmacy to manufacture the drug, and involve a GP who would be able to prescribe the drug as part of the therapy that's being provided."

Dr Bright said research in an Australian context would be quite easy, but the current barrier is the inability for drug companies to patent the plant.

"Because it comes from a plant, pharmaceutical companies don't have a vested interest in pursuing the effectiveness of this drug because they're unable to make profits from the use of this drug," he said, "the result being that the only research that's like to happen is that which is Government-funded."

Like Ms Gregory, Dr Bright has called on the Federal Government to investigate ibogaine as a potential drug treatment.

"There's an opportunity here for Government funding to investigate a treatment that isn't going to be investigated otherwise."

http://www.abc.net.au/news/2016-02-16/sunshine-coast-alt-therapist-pushes-for-iboga-trials/7173236

 

[mr peabody]

My son had ibogaine treatment for his meth addiction, and he has not taken any drugs since. He is a completely different boy with a very different outlook on life. This was the only treatment that worked, and I know if it wasn't for Ibogaine I would have buried him as he did try to take his life many times. He is a success story for Ibogaine.

My son and I are involved with a group of 20 people here that had Ibogaine treatment for their drug addiction, and not one has gone back to drugs or had any problems with the treatment. Some of them had been to rehab quite few times and still couldn't kick their habit until they had Ibogaine. One of the girls is now married with a child and living a life without drugs for 5 years now. Ibogaine is a prescription medicine here and has to be administered by a doctor in a nice clean clinic, not some dirty hotel room, and we don't call it a miracle drug. It is just a treatment that should be available to addicts that want to give up and can't do it with other treatments. Ibogaine here is a herbal product not a drug. Every single person has different experiences when they have Ibogaine so unless you or anyone else has tried it you can't really speak about it like we can. And another thing you don't have to have a drug problem to take it. We've had doctors, psychiatrists and herbalists try Ibogaine and they have all been impressed. And it is wonderful to finally get my son back and see the light in his eyes, like all the other ex-addicts here.

I am from New Zealand. I am Maori and we use the bush and forest to heal our sick ones. That is why I believe so much in Ibogaine and I have seen so many people successfully get off drugs using this treatment. And yes, I do agree that a doctor has to be involved and all the tests done before hand. We do not call it a miracle treatment or promise that everyone will become drug free, because it is still up to the person if they want to become drug free. Ibogaine gives them a 3 to 6 months chance after it has cleaned their insides to start working on their problems as to why they went down that track in the first place. Addicts can work on their problems with help as Ibogaine stops the craving for drugs for months. This is a very important part of the treatment once they have been cleaned.

-very thankful mother

 

[mr peabody]

Ibogaine worked really well for me. I was addicted to heroin for 10 years and after just one treatment with ibogaine, I had no withdrawals or cravings at all. But it's up to you to do the rest and stay off drugs. My tip is to try to change your life after ibogaine. Move to a different place, change your phone number. If you can't move, try rearranging the furniture in your home. It really works well if you are ready to quit and take that step into a new life, especially if you've been using for half your life or more.

-felix

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Ibogaine shouldn't be taken with SSRI or MAIO medications. If you're taking medications for depression, Ibogaine can be dangerous. If you're thinking about taking Ibogaine to help with depression, and you are already taking a prescription medicine, it’s important to talk to your treatment provider for more information.

-CTC

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I had the pleasure of doing ibogaine to cure my addiction to crystal meth, and it worked! I’m 100% better. This stuff is a miracle. We need to legalize it. I feel like I never even used meth and am therefore free from the feelings of needing it. God bless ibogaine.

-taija

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Rocky Caravelli, a former Oregon resident who operates an ibogaine treatment clinic in Mexico says he tried ibogaine in Portland to shake a methamphetamine habit. "It was the first thing that really worked for me," Caravelli said. "It cured the opiate withdrawals, and resolved my meth cravings. I was amazed."

 

[mr peabody]

Treating meth addiction with ibogaine

Methamphetamine is a poison that acts as a stimulant but then begins to systematically destroy the body. Meth releases high levels of dopamine when ingested and then blocks the normal flow of dopamine in the absence of the drug. This involves the reward system that regulates pleasure, happiness, motivation, energy, and functional ability. Meth changes the way the brain functions; and the brain becomes dependent on the drug to survive. Prolonged meth abuse brings with it serious health conditions including memory loss, aggression, psychotic behavior and potential heart and brain damage depleting the bodys resources. The physical effects start to deteriorate the body from the inside out, creating a devastating dependence that can only be relieved by taking more of the drug.

Ibogaine has a totally unique way of resetting or “interrupting” dopamine uptake pathways. These pathways are located in the brain’s pleasure and reward centers, which is why they are so connected with addiction. This ability to reset these crucial pathways—a singularly impressive achievement—is something no other drug, treatment, or substance has ever been shown to do. Patients that have used ibogaine for treating meth addiction report a complete absence of physical symptoms once treatment is over.

Ibogaine helps the person look deeply into his / her past to find the root problem of their addiction. Treatment with ibogaine induces visions which are dream-like even though the patient is awake. During these visions, patients are able to re-experience key life events in instructive ways, and see how they contributed to their addiction. Ibogaine treatment can provide patients with a significant shift of perspective. Ibogaine treatment is most effective when supported by a strong plan for re-entering life, including counseling, therapy and aftercare. The best way to get off methamphetamine is to make a complete break—but in a safe, medically supported setting.

Though ibogaine has a proven track record of success in treating addiction, it is vilified in the US and runs counter to the monetary interests of Big Pharma companies. The mechanism of action by which ibogaine works is still not fully understood, despite decades of research and hundreds of reports published in peer-reviewed medical journals demonstrating ibogaine’s ability to interrupt drug dependence. But the facts are clear: ibogaine treatment for methamphetamine addiction really works.

 

[mr peabody]

Ibogaine and meth addiction

Methamphetamine changes the way the brain functions and the negative effects of the drug are often noticed in a very short period of time. When the drug begins to wear off a person will notice increased irritability, anger and feelings of negativity. Because it blocks the flow of dopamine it is impossible to feel good after the meth is gone from ones system. With increased use meth causes neurotoxicity in the brain and central nervous system.

Meth affects the user both physically and psychologically, and the changes are dramatic. Physically, meth destroys the body from the inside out. It is extremely dangerous to vital organ function and causes ones appearance to change drastically for the worse. Psychologically, the drug can cause a decreased sense of well-being, depression, feelings of inadequacy and guilt, and with continued use can lead to amphetamine psychosis.

Ibogaine works by resetting the neurotransmitters in the brain. It is also a psycho-spiritual tool that helps the patient look deeply into their past to find the root problem of their addiction. People with addictions are usually victims of deep emotional traumas and seek to find an escape of this through their drug of choice. Ibogaine takes the patient on a deep introspective psychological journey that allows them to forgive others that have hurt them as well as forgive themselves for things theyve done that they regret and continue to carry with them.

Treatment with ibogaine induces visions which are dream-like even though the patient is awake. During these visions, patients are able to re-experience key life events in instructive ways, and see how they contributed to their addiction. They can also confront negative emotions including the fears that fuel the addiction pattern. Ibogaine treatment can provide patients with a significant shift of perspective.

This ibogaine healing process occurs in two phases - a visionary phase, and an introspective phase. The visionary phase produces a dream-like altered state of consciousness where past emotional traumas and memories can be processed. Treatment with ibogaine induces visions which are dream-like even though the patient is awake. During these visions, addicts are able to re-experience key life events in instructive ways, and see how they contributed to their addiction. The introspective phase enables addicts to conquer their fears, and the negative emotions caused by their past traumas. At the end of the 36 hour treatment, patients are left with a refreshing outlook on life and all of the possibilities it can hold.

 

[mr peabody]

"Where are you going?"


Methamphetamine

Methamphetamine is a dangerous and addictive drug that releases dopamine in the body when ingested. People use methamphetamine for the increased sense of pleasure it provides through its release of dopamine that cause neurotransmitters in the brain to release feelings of pleasure, happiness, increased self-esteem, and energy.

When use is discontinued meth blocks the normal flow of dopamine that is naturally present in the brain. Meth makes a person feel good temporarily and a feeling of increased overall well-being is usually noticed very quickly after taking the drug. A meth high can last more than eight hours, one reason the drug has become so popular and continues to enslave more people every day.

Meth changes the way the brain functions: the negative effects of the drug are often noticed in a very short period of time. When the drug begins to wear off a person will notice increased irritability, anger, and overall feelings of negativity. Because it blocks the flow of dopamine, it is impossible to feel good after the meth is gone from one’s system. With increased use, meth causes neurotoxicity in the brain and central nervous system.

Meth affects the user both physically and psychologically, and the changes are dramatic. Meth destroys the body from the inside out. It is dangerous to vital organ function and causes one’s appearance to change drastically. The drug can cause feelings of inadequacy, and with continued use can lead to amphetamine psychosis.

Traditional treatments for meth addiction usually involve some kind of twelve step program or something similar with success in treating the addiction between just one and seven percent. With such a low percentage of success, traditional treatments for methamphetamine addiction usually last 3-6 months but can take up to a year.

Treatment of meth addiction with Ibogaine is entirely different. With a 60-80 percent success rate in treating addictions, treatment with Ibogaine is done in less than a week and is administered in one 36 hour treatment. This psycho-spiritual treatment works in ending both the physical and psychological addiction of meth by treating both of these issues at once.

Physically Ibogaine works to relieve symptoms of withdrawal such as sweating, itchy skin, shakes, and twitches that users of meth often feel after the drug has worn off. Patients that have used Ibogaine for the treating meth addiction have reported a complete absence of the physical symptoms once treatment is over.

Ibogaine works by resetting the neurotransmitters in the brain. It also works as a psycho-spiritual tool that helps the patient look deeply into their past to find the root problem of their addiction. People with addictions usually are victims of deep emotional traumas and seek to find an escape of this through their drug of choice. Ibogaine takes the patient on a deep introspective psychological journey that allows them to forgive others that have hurt them as well as forgive themselves for things they’ve done that they regret and continue to carry with them.

This healing process is broken down into two separate phases starting first with visionary psychedelics and then moving to an introspective phase. The visionary stage lasts between four to six hours and produces a dream-like altered state of consciousness where past emotional traumas and memories can be processed. The second stage of Ibogaine which is introspective of the first allows addicts to conquer their fears and negative emotions that are caused from their past traumas.

At the end of the 36 hour treatment session patients are left with a refreshing look on life. Treatment with Ibogaine offers addicts a new found outlook on life and all the possibilities it can hold. By releasing old wounds that are embedded deeply in an addict’s psyche, Ibogaine allows for complete transformation at a deep psychological level.

http://www.ibogaineuniversity.com/me...ine-addiction/

 

[mr peabody]

Iboga treatment for methamphetamine addiction

Iboga helps eliminate both the physical and mental addiction that keeps meth addicts in their chains of addiction. Iboga helps to eliminate physical withdrawal symptoms such as the sweats, itchy skin, shakes, and twitches that meth users experience when the drug has worn off. It also relieves psychological addiction to the drug by taking the user on an introspective journey to identify the reasons one chose to do meth in the first place.

Meth is an extremely addictive stimulant that is very long lasting compared to many street drugs. It causes neurotoxicity in the brain and central nervous system and can lead to heart failure and eventually death. Meth releases high levels of dopamine and then blocks the normal flow of dopamine in the absence of the drug. These neurotransmitters involve the reward system which regulates pleasure, happiness, motivation, energy, and functional ability.

People use meth to feel better; it seems to increase self-esteem and libido and help with concentration, focus, alertness, and energy. But the effects are devastating in a very short period of time. The psychological effects of meth extend to amphetamine psychosis. The physical effects rapidly deteriorate the body, from the inside out.

Typical statistics quoted for success at standard methamphetamine rehabilitation centers using either the twelve step program or a variation of it, or some other non-iboga method of drug treatment, range from 1% to 7%, or less.

Iboga has an 80%-90%% rate of success for methamphetamine addiction. In addition to this high rate of treatment success, it takes as little as one week with one thirty-six hour treatment, for treatment with iboga to help end meth addiction.

Addiction to meth is normally two addictions, physical and psychological. The reason iboga is so effective is because it addresses both. Users often report a complete elimination of physical craving and an absence of the symptoms of physical withdrawal such as sweating and tremors following treatment.

Iboga's psycho-spiritual effects help users deal with the underlying emotional traumas they are seeking to escape. Iboga users are enabled to see the truth about their past and facilitated in bestowing forgiveness to others, but most importantly to themselves. As a result they are able to envision their future, free from the guilt that enslaved them.

 

[mr peabody]

There are 3 main options for ibogaine treatment (after a small test dose)

- single administration of 1 high dose ibogaine (with booster doses over the next few days/weeks if needed)
- single day/night of administration of multiple large doses spaced out by a few hours (with booster doses over the next few days/weeks as needed)
- small daily doses of 25-300 mg/day, where the dose is gradually increased each day until it is felt to have been effective for eliminating WDs/cravings

http://www.dialogue.space/ibogaine-help-and-advice/

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Iboga accumulates in the body. It remains in the body for more than 4 weeks. This means that all the drops you take in a 5-week period will accumulate and remain in your body until they slowly wear off. If the dose you take exceeds 10 drops a day, physical and psychological effects effects can occur. Be aware of that some people respond highly sensitively to just a few drops. It is important to listen to the signs of your body at all times and adjust your dosage accordingly. Do not take the iboga tincture before going to sleep. The plant gives you energy and might cause insomnia.

Whilst treating yourself with iboga, it is advisable to keep stimulants such as coffee to a minimum, as well as tobacco or certain herbs. Your receptors will become very sensitive and you may have an unexpectedly strong reaction to them. It is strongly discouraged to combine iboga with other psychedelics. Iboga should never be combined with anti-depressant medication such as SSRI's. Such a combination would be very dangerous.

https://www.dmt-nexus.me/forum/defau...=posts&t=52279

 

[mr peabody]

"All those moments will be lost in time, like tears in rain..."


Daily low dosing

Dr. Kenneth Alper was among the attendees who gave a presentation on the benefits of ibogaine to the Catalan Ministry of Health. He believes that ibogaine's most likely path to prominence in the U.S. will be as a medication for meth addiction, for the simple reason that doctors and treatment providers have found that small daily doses seem to work better for meth addiction than the mind-blowing "flood doses" used on opiate addicts. Alper says no one thought to try non-psychedelic quantities of ibogaine until recently...

http://archive.seattleweekly.com/hom...129/story.html

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Ibogaine has also been given in regimens of small daily doses of 25 to 300 mgs/day and in small daily doses where the dose is increased on a daily basis until the desired interruption of drug dependence is accomplished. These low dose regimens can be traced back some decades to the work of Leo Zeff who in the case of a single patient provided ibogaine on an "as needed" basis via nasal administration to a cocaine dependent patient to substitute for his cocaine use. Lines of ibogaine were somewhat equivalent to lines of cocaine and the patient ceased cocaine use after a week of this daily self-regulated ibogaine regimen. Additionally, reports from Canadian sources indicate multi-week low dose ibogaine therapy 20 mg/day following a therapeutic dose of ibogaine in the treatment of cocaine dependence. Further, reports throughout the ibogaine provider community indicate the use of multiple dosing of varying strength doses over varying time periods in the treatment of opioid dependence. As with all determinations in medicine, decisions must be taken based on observations of the patient, knowledge of the disorder(s) and the medication(s) used.

https://truthtalk13.wordpress.com/20...gaine-therapy/

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For those flooding

Best to have new routines in place before the session. It really isn't will power as much as practical plans for dealing with life, and the belief that life can change. All that ibogaine can guarantee is to interrupt the addiction. The more one plans how to handle the stressors, the better the chances of succeeding at whatever goal one has.

I work with people to encourage the best pre and post care possible. Even for those who go back to using, I still see benefit. Like shame and guilt reduction, resolution of issues caused by early trauma, etc. It is not often mentioned, but some require 2-3 sessions. Ibogaine seems to target the most pressing issues first. With a junkie that would be the addiction. Maybe next time, deeper delving into emotional wounds which could have caused using in the first place. I myself have had one flood only, and it worked.

BOOSTERS. No-one should be sent home from a session without some boosters. These are smaller doses of the medicine, safe to take at home. Most benefit from one at 30 days.

-lol_Taco

 

[mr peabody]

Ibogaine and methamphetamine

Last month, dozens of ibogaine researchers, activists, and treatment providers gathered for a conference in Barcelona, where topics included safety and sustainable sourcing of ibogaine from Africa. Dr. Kenneth Alper was among the attendees who gave a presentation on the benefits of ibogaine to the Catalan Ministry of Health. The NYU prof believes ibogaine’s most likely path to prominence in the United States will be as a medication for meth addiction for the simple reason that doctors and treatment providers have found that small daily doses seem to work better for meth addiction than the mind-blowing “flood doses” used on opiate addicts.

"No one thought to try non-hallucinogenic quantities of ibogaine until recently," says Alper.

Clare Wilkins, a facilitator of over 700 ibogaine treatments, has been experimenting with small daily doses of ibogaine for people with heart conditions or other health problems that make flood dosing unadvisable. "The non-psychedelic regimen seems very successful," she says.

-Keegan Hamilton

-----

Try small daily doses of 25-300 mg/day, where the dose is gradually increased each day until it is felt to have been effective for eliminating WDs/cravings. Iboga accumulates in the body. It remains in the body for more than 4 weeks. This means that all the drops you take in a 5-week period will accumulate and remain in your body until they slowly wear off. If the dose you take exceeds 10 drops a day, physical and psychological effects effects can occur. Be aware of that some people respond highly sensitively to a few drops only. It's important to listen to the signs of your body at all times and adjust your dosage accordingly. It's better not to take the iboga tincture before going to sleep. The plant gives you energy and might cause insomnia.

Whilst treating yourself with iboga, it is advisable to keep stimulants such as coffee to a minimum, as well as tobacco or certain herbs. Your receptors will become very sensitive and you may have an unexpectedly strong reaction to them. It is strongly discouraged to combine iboga with other psychedelics. Iboga should never be combined with anti-depressant medication such as SSRI's. Such a combination would be very dangerous.

-ed

 

[mr peabody]

Using ibogaine for methamphetamine detox

I was a methamphetamine addict for 17 years, and after many programs, and medications for bi-polar or psychotic tendencies, Ibogaine was the only thing that ever removed the imprint of stimulants from my life, and the mental fractures diagnosed by psychologists. Stimulants are very different than other drugs, causing an entirely different type of damage requiring a completely different approach to healing the body, especially the mind.

Methamphetamine probably does more damage to the brain than any other substance. I have seen permanent damage in others.

Recovery from methamphetamine addiction starts with three days off meth. Ibogaine is a central nervous system stimulant, and you want to start feeling better before proceeding with the treatment. By the 3rd day cravings to use become extremely intense. Normally ibogaine is given in 1/4 doses to help ease those cravings. This helps people stay comfortable and get through those initial difficult days coming off meth. This helps people to eat and rest well, while relieving anxiety and the compulsion to use. This stabilizes and enables you to feel well enough to permit the body's return to strength. By the time you do the flood session, you already have the real healing properties of the ibogaine metabolizing.

It takes much longer for the brain to heal from stimulant use than from opiate dependency. Meth really "amps up" the release of dopamine over and over, so the ability to feel good naturally has been gone for years. This is something that I noticed right away; I did not have to go through several months of waiting to have energy and a clear minded ambition, along with other basic functions. This is why relapse was so predominant. You just get tired of waiting to feel better, and right away, when you use, it comes back. So it's a tricky drug and very deeply embedded in the psych. It's almost like there are two kinds of addictions—dopamine vs endorphins. Both are vital neurotransmitters for feeling well.

I might not have understood stimulant treatment if I hadn't had the experience myself. I tried every kind of program, psych medications, jails and meetings, rehabs, some for 6 months, long term sober living, everything I could do in earnest attempts to work this out, resulting in a year or two off drugs under very confined life style, feeling vulnerable, waiting for it to come back over and over. Very frustrating. This is why I have spent the last eleven years learning, documenting and sharing my information with various ibogaine providers. Ibogaine actually fixes the mind and body.

Crack and cocaine have properties similar to methamphetamine and the treatments are similar because they cannot be in the system along with ibogaine. People have had seizures and cardiac arrest from the combination of ibogaine and other stimulants. I have heard of close calls, and even some deaths directly related to mixing ibogaine with stimulants. Unlike opiates, ibogaine has zero tolerance for stimulants in the system.

Screening needs to be done carefully because ibogaine is a stimulant and can trigger some of these conditions. The mind must be clear in preparation so that confusion doesn't interfere with the treatment. The mind can only handle so much before undesired side effects and a break-down of the psych may occur. This is also why treatment for stimulants requires multiple dosing along with a thorough evaluation of someone's mental stability. Stimulants invite so many other conditions on top of the dependency, one must work hard to avoid complications.

People choosing to use ibogaine for meth or crack must have a set of questions for any provider to ensure they receive the treatment they need. Ibogaine is not a "one size fits all treatment," and some providers have not worked with stimulants very often. I always suggest getting as much information as possible about how they do the treatment and what their personal and clinical experience is.

Stimulant users seem to purge more than opiate users. They also seem to struggle in "letting go" to the ibogaine, another reason for the introductory doses. It helps people to relax and feel better. In treating stimulant use it's all about control. Everyone is different and has different experiences in their past, and it's the provider's job to see where you're "at" in order to assist in making it a comfortable and effective treatment.

-anon

 

[mr peabody]

Methamphetamine is known to prolong the QT interval even though it does not interact with the hERG cardiac channel, as well as to affect CYP2D6 metabolism. Ibogaine has been shown to potentiate (increase) the effects of methamphetamine by sensitizing receptors that mediate its effects.

It is recommended that patients cease consumption of methamphetamine for at least five days prior to administration of ibogaine.

https://www.ibogainealliance.org/guidelines/stimulants/

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The dose for a flood dose is around 19mg/kg of body weight. So if you weigh, say, 60kg, then you'd want about 1140mg. it's best divided into 3 doses, start with 100mg, then an hour later take the majority of the rest and then an hour later take the rest. You have to get your heart checked out first because ibogaine has killed people due to heart problems. Also, you absolutely MUST have supervision the whole time to make sure you're okay and that you don't do something stupid. For me, ibogaine lasted 3 days before I was able to take care of myself again. I had no idea whether I was awake or asleep during it, I wasn't watched anymore on the third day and I thought I was fine but I was actually dreaming while I was awake and I ended up writing a terrible email to my boss and I may have also driven my car but I'm not sure. You really need to understand what you're getting yourself into with ibogaine.

-Xorkoth

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I am an addict who was cured with Ibogaine. I am 2 years off crystal meth. I’m telling you this from the deepest part of my heart. Ibogaine is intense. You are sick, you vomit, you feel like you're dying, you must look all your wrongs in the face. It's hard. I peed myself it was so overwhelming. BUT, it does work. When I went to do ibogaine I was living on the street, 98 lbs at 5’5 and dealing meth. I had nothing and nobody. My whole family had given up on me. But with the help of ibogaine, my mother and I are close again.

My heart aches that there are people out there still suffering, who don't even know the cure is here.

-TheKey

 

[mr peabody]

High doses of CBD found to reduce methamphetamine consumption

A new study in the Journal of Psychopharmacology provides evidence that CBD, a component of cannabis, can inhibit the motivation to consume methamphetamine.

The preliminary findings suggest that the substance could be useful in fighting addiction to methamphetamine, which has become one of the most common drugs of abuse around the world.

“One focus of my laboratory is to understand the neurobiology of methamphetamine addiction so that we can discover effective treatments to reduce this burden on our society. Cannabinoids are showing promise as medications for a number of mental health disorders and symptoms in preclinical models, including drug addiction and relapse for opiates and psychostimulants,” said study author Jennifer Cornish of Macquarie University.

“Methamphetamine is a psychostimulant, however, the effect of CBD had not yet been investigated for reducing reward or relapse in rats experienced at lever pressing for intravenous methamphetamine infusions. As it is known that CBD acts on a number of targets in the brain that may impact on the pharmacology of methamphetamine use, this study was a logical next step for discovering more about methamphetamine addiction and the effects of CBD treatment.”

The researchers found that treatment with 80 mg/kg of CBD — but not smaller doses of 40 mg/kg or 20 mg/kg — reduced the motivation to consume methamphetamine in rats trained to self-administer the addictive stimulant.

But CBD did not impact the motivation to consume sucrose, suggesting the effects are somewhat targeted rather than affecting reward mechanisms in general.

“Medicinal cannabis covers a broad range of chemicals that are found in the cannabis (marijuana) plant, many of these are not psychoactive (unlike delta-9-tetrahydrocannabinol, the main psychoactive component of marijuana), and each may have a medical application — yet to be discovered,” Cornish told PsyPost.

“This study has shown that high doses of CBD can act to reduce methamphetamine consumption and also relapse to taking methamphetamine. More other studies need to be done prior to the use of CBD in human population of methamphetamine addicts – but this study is a first step for understanding the potential use of CBD treatment in methamphetamine addiction.”

The study — like all research — includes some limitations.

“The major caveats here are that the study is conducted in rodents, and uses high doses of CBD. However, there is substantial overlap between the neurobiology of rats and humans, and pre-clinical studies such as this provide important information on the potential use of new chemicals in human disorders,” Cornish explained.

“From this data set we are able to design further experiments that not only discover the effectiveness of CBD as a therapy for methamphetamine addiction, but also the mechanisms by which CBD can reduce methamphetamine intake. By understanding these mechanisms we can inform the discovery of more targeted therapies that would work like CBD, yet with smaller therapeutic doses.”

“There is so much more to discover with over 400 chemicals in the cannabis plant, including over 70 cannabinoids. The potential therapeutic benefits of these are great and should be explored to develop targeted therapies for mental health (or other) disorders,” Cornish added.

https://www.psypost.org/2018/11/study-high-doses-of-cbd-can-act-to-reduce-methamphetamine-consumption-in-rodents-52602

 

[mr peabody]

"I only do eyes... just eyes..."


The health risks of ibogaine treatment

There haven’t been many ibogaine-related deaths reported in the last five years, but the ones we do know about all seem to have some elusive factor. The 2014 death of a woman in a Costa Rican ibogaine clinic was actually from a heart attack, but the autopsy report was inconclusive as to whether there was ibogaine in her system when she died. Most reports blame the clinic, which was operating outside of Costa Rica’s regulated licensure program for ibogaine providers. They closed after the woman’s death, suggesting the clinic didn’t properly check the patient’s medical history for pre-existing cardiac conditions.

That same year, an Australian man named Brodie Smith died in his hotel room in Thailand. His girlfriend claimed he died after taking ibogaine and having trouble breathing, but the reports here are also convoluted—some accounts suggest he actually overdosed on methamphetamine (the addiction he was hoping to treat with ibogaine therapy) before ever taking ibogaine or still had methamphetamine in his system at the time of administering ibogaine.

The unknown factors in both cases highlight ibogaine’s biggest weakness—lack of regulation. Ibogaine is still illegal in the United States, so finding treatment generally requires leaving the country. Internationally, ibogaine providers run the gamut from professional clinics to hotel room pop-ups.

But these stories contain other clues regarding risk factors to consider if you’re thinking about ibogaine treatment. Perhaps the most helpful resource on this topic is The Clinical Guidelines for Ibogaine-Assisted Detoxification, published in 2015, which includes all known health risks, exclusion criteria, and recommended health assessments for ibogaine treatment. As in these two stories, the complications explored in this publication often result from a provider not collecting key health information or a patient not being completely honest about their medical history.

Understanding the risks

The reported number of deaths from ibogaine is relatively low. According to a 2012 report, there were nineteen reported cases of people dying from ibogaine between 1990 and 2008. Even so, it’s important to educate yourself before making decisions about treatment. Some medical conditions, like cardiac disorders, automatically flag you as an at-risk patient whereas the implications of other medical conditions, like depression, are still not understood. The exclusion criteria for ibogaine depends on the specific resources consulted, and researchers say the high number of people with drug dependency and concurrent mental illness necessitates a reconsideration of the exclusion criteria. However, the risks listed here include the National Institute on Drug Abuse (NIDA)’s criteria and offer a discussion on some of the finer points and treatment considerations.

Cardiac disorders

Cardiac disorder is at the top of the list for exclusion criteria largely because the relationship between ibogaine and the heart is still relatively unknown. Ibogaine increases your heart rate and inhibits particular gene channels that affect cardiac action, making cardiac arrest the most common cause of ibogaine-related deaths—of the nineteen deaths reported between 1998 and 2008, six were related to cardiac complications. All of these deaths were related to pre-existing conditions, but a recent case study reported a man who died from cardiac arrest after administering ibogaine with no known history of cardiac problems. Based on this, researchers suggested ibogaine may cause cardiac arrest without preexisting conditions. More research is needed to understand the role of ibogaine in cardiac action, but it is clear that an existing cardiac disorder could be a major disqualifier if you’re interested in ibogaine therapy.

Concurrent drug use

Ibogaine is known to intensify the effects of opioids, so it’s extremely important that those undergoing ibogaine therapy do not have drugs in their body at the time of treatment. For this reason, most clinics operate on a “next fix” schedule—meaning, when used as an addiction interrupter, ibogaine is usually administered at the normal time of the “next fix,” so 8 hours after the last dose of heroin or morphine and 24 hours after the last methadone dose. Operating on this schedule, most people are just starting to show symptoms of withdrawal when they go into treatment. Administering ibogaine with substances like heroin, methamphetamines, or cocaine in your system is a serious risk.

HIV and HCV

The reason for including HIV and Hepatitis C (HCV) on the list of exclusion criteria is more out of lack of research than conclusive evidence that ibogaine interacts poorly with HIV or HCV patients. Most studies have not included HIV-positive patients, although there have been reports of non-symptomatic HIV patients who have undergone treatment without issue. While the NIDA originally included HIV and HCV on their list of exclusion criteria, lack of evidence shouldn’t necessarily keep people from undergoing needed addiction treatment.

Mental illness

Mental illness is another major topic of debate surrounding ibogaine. While conservative researchers think mental illness should be an automatic disqualifier, others argue that most people use ibogaine to treat addiction, which often overlaps with mental disorders like depression, anxiety, and PTSD. Lumping all mental illness into an exclusion criteria would discount a large portion of the population that ibogaine seeks to treat, and none of the ibogaine-related deaths recorded thus far showed mental illness as a central factor. More research is clearly needed, but, meanwhile, it is recommended that all patients get mental health and personality assessments before treatment and discuss any implications with their provider.

Gender

As with some other psychedelics, ibogaine has a stronger effect on women than men. This does not seem to only be a case of weight to dose ratio; rather, it seems women are actually more sensitive to ibogaine’s effects. Of course, being a woman doesn’t disqualify you from ibogaine treatment, but it’s important to understand that a particular dose may have a stronger effect on you than your male cohort.

Ultimately, these risks are all mitigated with the help of a trained guide or nurse, so it’s important that any clinic you choose has a trained professional on hand should a crisis arise.

What an ibogaine provider should ask you for

The majority of risks associated with ibogaine could have been mitigated by an improved medical screening process prior to treatment. As ibogaine therapy is still a loosely regulated field, it’s important that patients are assured of their provider’s professionalism and feel comfortable that any medical emergencies will be properly handled.

Basically, the more medical information gathered beforehand the better—not only for your own health but also for a provider wanting to track recovery rates—but there are four key things every provider should ask you for:

1. EKG: An EKG tests for electric imbalances in your heart and helps determine if you have an existing cardiac condition. Any patient undergoing ibogaine treatment should be required to submit an EKG to confirm their cardiac health. An ECG is also recommended for patients over 60.

2. Bloodwork: Blood chemistry is indicative of a patient’s overall health, particularly their liver health (which is of concern with ibogaine and other addiction treatments). Typically, a patient should receive a SMA-20 test (which evaluates chemistry levels) and a CBC test (which assesses total blood count).

3. Medical History: Reputable ibogaine providers should ask for your complete medical history, either in the form of a questionnaire or by accessing your medical files. You should be completely honest when answering all questions to avoid possible risks.

4. Mental and Personality Assessments: Ideally, ibogaine providers have every patient complete a Beck Depression Inventory and a Multiphasic Personality Inventory to determine the overall mental health of a patient. Some mental disorders, such as chronic major depression, may be a disqualifier for treatment.

The most important part of the screening process is trust and open communication. As you collect these records and start a conversation with a prospective provider, you should feel certain that all your questions are answered fully and honestly so you can go into treatment feeling confident.

The conversation about ibogaine and health risks is far from over. But even with these risks, it’s clear from research and personal success stories that ibogaine can be effective as an addiction interrupter. It’s only by educating individuals and fostering honest communication between providers and patients that we can mitigate the risks of ibogaine treatment and maximize its unique benefits to society as an addiction treatment.

https://psychedelictimes.com/iboga/health-risks-ibogaine-treatment-what-every-ibogaine-provider-should-ask-you-for/