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Meth & Zofran

Yes it is safe, there is no dangerous interactions between them
 
Depends on the dosage imo
Use of ondansetron has been associated with prolongation of the QT interval, which can lead to the potentially fatal heart rhythm known as torsades de pointes.
Click to expand...
from wiki
So combining it with a stimulant like meth could increase this risk and increase side effects, but I think you should be alright.
 
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