MDMA and Terbinafine (Lamisil)

spephspeph

Bluelighter
Joined
Aug 14, 2011
Messages
131
Location
London
I know this has been posted a fair bit, but I can't seem to find a definitive answer.

Terbinafine inhibits the CYP2D6 enzyme, one of those used to metabolise MDMA.

I was planning on taking MDMA tonight, however I've been on Terbinafine for the past month (and likely to be on it for the next 2-6 months, thank you fungal toenail).

As it inhibits, could I get away with taking smaller doses of MDMA - for instance pre-dosing 25-50mg into some capsules? Would this lessen any horrific effects?
 

FormerBeagle

Greenlighter
Joined
Apr 15, 2019
Messages
30
There are multiple cyp isoforms that metabolize mdma. If one is inhibited, the others (3a4 and 1a2 in this case) can take over. I’d wager there will be little effect. In fact the 2d6 pathway is implicated in producing reactive metabolites of methylenedioxy compounds, and you may be better off with it inhibited.
 

indigoaura

Bluelighter
Joined
Jan 4, 2009
Messages
489
I would not personally risk it. My friend had a grand mal seizure trying something similar.
 

FormerBeagle

Greenlighter
Joined
Apr 15, 2019
Messages
30
That's actually much better advice. The real question here should not be how is the mdma going to affect the antiseizure med, not the other way around
 
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