I only use Loperamide to help me get off baseline. 24-36mg seems to be the sweet spot for me with a moderate habit. High dose Loperamide feels dirty, lethargy-inducing, and just overall very toxic. There is no real "high", but I've found it to be mildly axiomatic, especially when fiendin for real CNS active opiates. That small effect, while consistent for me personally, isn't worth the other nasty side effects alone, much less the added health risks. It induces a dirty near coma-like drowsiness. I've slept for 18hrs straight and have been very angry when I've had something to do but need to sleep another 12.
Use it sparingly and in the lowest doses possible to ease withdrawal.