When hERG is inhibited it will cause torsades. You might find this interesting though.I guess my question is that if hERG is inhibited without causing torsades (which without medical attention is pretty close to a death sentence) going to induce like cardiac hypertrophy or some other nasty more permanent effect.
Like a month ago I was shown the rough SAR for the hERG binding site. The pharmacophore kind of looked like a slice of pizza pointed upwards, with big aryl or other fatty groups at verticies (especially the bottom 2) and a protonatable tweet nitrogen in the middle. (I'm no med chemist but always love learning simple SAR).