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List of Dangerous & Potentially Unsafe Combinations

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any major dude

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Here we'll try to keep a list of combinations of drugs that aren't safe to take in combination. This will be a work in progress & this list will not be exhaustive, so please still research things thoroughly before you ingest them!

Thanks to SurvivedAbortion for getting the ball rolling on this thread!

If your combination is not in the list, or you would like to ask about a specific combination or discuss potentially dangerous/risky combinations, or even make suggestions for this thread, please visit the Dangerous Combination Discussion Thread.

It would also be wise to check out the Medication & Supplement Interaction Thread for further information on medication reactions beyond simply stating whether a combination is dangerous or not.


If you see anything wrong in this list or something that needs to be added, please either post in the above thread, or PM one of the PD moderators and we'll get right on it.

Table of Contents

You can use the find/search function (Ctrl + F) to search for any of the sections mentioned in the contents and quickly find dangerous combinations for these drugs.

Known Dangerous Combinations
  • MAOIs
  • SSRI/SNRI antidepressants
  • Anticonvulsants
  • Beta-blockers
  • Triptans
  • 5-HTP
  • Alcohol
  • Ibogaine
  • Serotonin releasers
  • Stimulants
Potentially/Likely Dangerous Combinations
  • Serotonin releasers
  • Stimulants



Known Dangerous Combinations


MAOIs (e.g. Phenelzine, Tranylcypramine, Selegiline):

X All phenthylamine psychedelics (e.g. DOx, 2C-x, 3C-x, TMA-x, 25x-NBOMe)
X aMT (alpha-Methyltryptamine)
X MDxx (e.g. MDMA, MDA, MDEA)
X Other serotonin releasers (e.g. 6-APB, 5-APB, 5-API, 5-IAI, MDAI)
X All cathinones
X DXM (Dextromethorphan)
X Ibogaine
X SSRI/SNRI antidepressants (e.g. Sertraline, Seroxat)
X Methoxetamine
X Tramadol
X 5-HTP

SSRI/SNRI antidepressants (e.g. Sertraline, Seroxat):

X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X DXM (Dextromethorphan)
X Ibogaine
X Tramadol
X 5-HTP

Anticonvulsants (e.g. Lithium, Valproate):

X All classical psychedelics (5HT-2a agonists like LSD, mushrooms, 2C-B)
X All phenethylamines
X Ibogaine

Beta-blockers (e.g. Propranolol, Atenolol):

X All stimulants and empathogens (e.g. Amphetamine, Cocaine, MDMA, Mephedrone)
X aMT (alpha-Methyltryptamine)
X LSD/LSA
X Datura/Belladonna/Brugmansia

Triptans (e.g. Sumatriptan, Rizatriptan, Zolmitriptan):

X aMT
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X LSD/LSA

5-HTP:

X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X All SSRIs/SNRIs (e.g. Sertraline, Seroxat)
X MDxx (e.g. MDMA, MDA, MDEA)
X Other serotonin releasers (e.g. 6-APB, 5-APB, 5-API, 5-IAI, MDAI)

Alcohol (e.g. Beer, Wine, Vodka):

X Ibogaine
Additionally, tyramine-containing alcoholic beverages such as draught beer and wine should not be combined with any of the following:
X aMT
X Ayahuasca/Pharmahuasca
X 2C-T-7
X Other MAOIs (e.g. Phenelzine, Selegiline)

Ibogaine:

X Alcohol
X DXM
X All SSRIs/SNRIs (e.g. Sertraline, Seroxat)
X MDxx (e.g. MDMA, MDA, MDEA)
X Other serotonin releasers (e.g. 6-APB, 5-APB, 5-API, 5-IAI, MDAI)
X All other stimulants (e.g. Amphetamine, Cocaine, MDPV)
X All anticonvulsants (e.g. Lithium, Valproate)
X Antibiotics
X Grapefruit Juice
X Quinine (Tonic water)

Serotonin releasers (e.g. MDMA, MDA, MDEA, 6-APB, 5-APB, MDAI, Mephedrone, Methylone):

X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X DXM (Dextromethorphan)
X Ibogaine
X 5-HTP

Stimulants (e.g. Amphetamine, Cocaine, MDPV, Methcathinone):

X Beta-blockers
X Ibogaine


Potentially/Likely Dangerous Combinations

Adrenergic autoreceptor antagonist antidepressants (mirtazapine, yohimbine)

X Dissociatives (DXM, ketamine)
X Ibogaine

Serotonin releasers (e.g. MDMA, MDA, MDEA, 6-APB, 5-APB, MDAI, Mephedrone, Methylone):

X 5-MeO-MiPT and 5-MeO-DiPT
X Methoxetamine

Stimulants (e.g. Amphetamine, Cocaine, MDPV, Methcathinone):

X All of the NBOMe series (e.g. 25C-NBOMe, 25I-NBOMe)
X 5-MeO-MiPT and 5-MeO-DiPT
X Bromo-DragonFLY
X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)

Alcohol (e.g. Beer, Wine, Vodka):

X Dissociatives (e.g. Ketamine, DXM, PCP, Methoxetamine)
X 5-HTP
 
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