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Bupe Lifting the ceiling effect of Buprenorphine

H

Hazzel

Greenlighter
Joined
Jun 26, 2018
Messages
12
Hi! I'm new to the forum so i hope i'm in the right section!

I was wondering if there's any way to lift the "ceiling effect" for everyday users of Buprenorphine, since you don't get much of a high once you've reached the ceiling effect 24/7. So: Anyone know of any ways to lift the ceiling effect? I had my thoughts around DXM lowering opiate tolerance? Could that work in low doses? I also read about [FONT=arial, sans-serif]St. Johns Wort metabolizing the Buprenorphine into Norbuprenorphine which is a full agonist? Anyone have any successful experiments regarding this topic? Or any other ways of lifting the ceiling effect? Benzos/pregabalin and similar solutions wouldn't work since SWIM gets tested for these kinds of meds on a regular basis. SWIM also tried Hydroxizine which is an antihistamine but not with satisfying results, if any increase at all more than maybe a little placebo.[/FONT][FONT=arial, sans-serif]
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Different modes of use have different rates of absorption afaik with sublingual being lower than Nasall.
 
Lifting the ceiling affect of Buprenorphine will not be possible, It is not a full on opioid receptor agonist (Some of it’s metabolites may be). It is only a partial receptor agonist, and like any other partial receptor agonist, it will have a ceiling effect. I used to take Buprenorphine daily for over 2 years in the form(s) of suboxone and zubsolv. I do think the zubsolv is much better than the suboxone btw! I also think trying to use dxm for opi tolerance may not be too effective. While dxm can prevent opiate tolerance, I don’t see it reversing your tolerance to the degree that you would just all of a sudden get really lit off bupe. When I was on bupe I would potentiate it with benzodiazepines and other miscellaneous sedatives. This can potentially be very dangerous and should only ever be done with a word of caution, as it can possibly hurt or kill you
 
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