i've been doing between 0.5 - 2 pills over the course of the weekend (thurs-sun) for the past 3 months, and have been plugging the past couple of weeks to maximise the effects. but even the weekends where i only did 0.5 of a pill decreased my tolerance for the next week.. that said, most of these pills have been of the md-xx medium variety, a few i suspect with amphetamines, and my amphetamine tolerance is quite high. going clean for a few months in august though - can't wait for it.
edit: i've never actually had a depressive comedown.. the first time i took k (which was sold to me as e) i felt a bit flat, but that was only because it was my first drug experience altogether, and i was damn well wanting more. ha