I quit using pain pills in June, about 9 months ago and haven't taken any pills since. I do take kratom daily to get rid of PAWS and don't feel any WD symptoms in the morning before taking kratom like I would when I was taking pills. Last night I snorted a 30MG MS Contin and IV'd 1 MG of diladid and felt no effects. Is this because kratom has my tolerance high or does it block other opiates. I was very surprised that the IV had no effect even though it was a low dose.
Opioids Kratom blocking opiates?
- Thread starter thurston
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Znegative
Bluelight Crew
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hey burn out, empty out your PM box, I tried sending you a question in regards to replacing subs with kratom, sorry to derail the thread. I have heard that kratom does have a higher binding affinity than morphine, I'll try to pull up it's binding affinity information
EDIT// Here it is:
MG has been reported to have activity (Takayama et al.2002) in the classical electrically stimulated guinea pig ileum isolated tissue preparation (kosterlitz and Robinson 1957). Both MG and 7-OH-MG displayed nearly the same intrinsic activity as morphine. MG was about one-fourth as potent as morphine sand 7-OH-MG was about 10-fold more potent than morphine (Kitajima et al.2006)
source
EDIT// Here it is:
MG has been reported to have activity (Takayama et al.2002) in the classical electrically stimulated guinea pig ileum isolated tissue preparation (kosterlitz and Robinson 1957). Both MG and 7-OH-MG displayed nearly the same intrinsic activity as morphine. MG was about one-fourth as potent as morphine sand 7-OH-MG was about 10-fold more potent than morphine (Kitajima et al.2006)
source
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Sorry about that, I cleared up some room.
As for higher binding affinity than morphine I've read that before too and I would not recommend taking strong doses of kratom and opiates simultaenously (makes me feel sick and out of it) but if you simply wait 5 or 6 hours the kratom should be worn off and allow the opiate to work. its not like sub with a 36 hr half life.
Ive noticed that, after being on kratom for a long time if I switch to a mild opiate like norco for a few days i notice withdrawal from the kratom. i dont have any of the typical opiate wd symptoms like runny nose, hot cold flashes, stomach issues, etc but something just feels off to me, which makes sense i think because kratom has other actives in it and is simply a very different opioid compared with hydrocodone.
As for higher binding affinity than morphine I've read that before too and I would not recommend taking strong doses of kratom and opiates simultaenously (makes me feel sick and out of it) but if you simply wait 5 or 6 hours the kratom should be worn off and allow the opiate to work. its not like sub with a 36 hr half life.
Ive noticed that, after being on kratom for a long time if I switch to a mild opiate like norco for a few days i notice withdrawal from the kratom. i dont have any of the typical opiate wd symptoms like runny nose, hot cold flashes, stomach issues, etc but something just feels off to me, which makes sense i think because kratom has other actives in it and is simply a very different opioid compared with hydrocodone.