The whole Olney's lesions thing...not likely. Professor Olney's theory is flawed for several reasons. First, the dose given to the rats was about ten times the dose given for human anesthesia, which is still well above the recreational dose. Second, an unpublished study using monkeys (a lot closer to humans genetically) found it completely impossible to duplicate Olney's results, even at higher doses. Olney's results were actually from MK-801 (dizocilpine if you care), a research drug that only bonds to the NMDA receptors, causing overexcitement which releases the HS470 (heat shock, I'm not sure if that's the right number, it doesn't really matter) protein which basically destroys every cell in its path to avoid total shutdown of the brain. Ketamine is very promiscuous, it bonds to receptors that prevent the overexcitement from happening way before the dose could cause it. Rats don't actually have those receptors. Olney's results also required several hours of constant exposure to the drug. The half-life of ketamine in the body is only half an hour.
Oh, and rats also have a much higher brain metabolism, meaning that their brains require much less stimulation to overheat. I'm sure their are more reasons, but I'm not going to say that the lesions are completely impossible, only fairly improbable. Sorry, but I did a very long report on Special K for my advanced chem. class. Read "Ketamine: Dreams and Realities" by Karl Jansen for a lot more information. Oh yeah, K is much, much safer than pure MDMA, and with the cocktail of drugs in the average pill, ecstacy is one of the most dangerous drugs (I understand that this opinion will not make me popular) but alcohol is still the most dangerous (our government is really fucked up). "LSD and ketamine, which produce profoundly altered states of being, have the least lasting effects on the human body...Alcohol may be one of the few drugs that can cause the level of actual brain damage required to produce a chronic psychosis" -Karl Jansen M.D., Ph.D, member of the Royal College of Psychiatrists
[This message has been edited by wickedclown_stl (edited 26 June 2001).]