i think an ole reference to Zinberg may be required here, the effects of a drug are experienced in relation to
Drug - Physiological effects of the substance, CNS Depressant, CNS stimulant, Hallucinogenic
Set - the mindset of the individual, the physiological makeup of the person and the state of their body, eg tired, rested, depressed, happy ect .
Setting the setting that the individual is in whether they feel safe, unsafe, experiencing something new or
experiencing something that is perceived as more common, emotional connection to the setting or the people there; feeling part of a movement or not.
pills going mainstream is a pretty easy way to say that something isn't new or that it has been experienced so often that the initial meaning or effect has changed to something else.
its no longer "as good as i remember it" prob means more that "ive done it to death
socially if you want to look at this, society has set huge benchmarks for making things that are perceived as naughty or exciting able to be achieved as the difference or gap between social norms and doing deviance increases.
i think that the "more is good" mantra of society has very much rubbed off onto the pills scene where a subtle changes in consciousness are no longer the key to using substances- obliteration of self seems to be more the go