Is caffine a clinically significant phosphodiesterase inhibitor at normal doses?

[VelocideX]

Is caffeine a clinically significant phosphodiesterase inhibitor at normal doses?

I've found conflicting information. A quick search of erowid reveals an article suggesting it isn't, yet many bodybuilding websites suggest it is.

So yeah, does caffeine significantly inhibit phosphodiesterase at reasonable doses? (~100mg)

edit - i cant spell

 

[pill_jockey]

It seems that it is might want to check out these journal articles

Quantitative analysis of the effects of caffeine on sperm motility and cyclic adenosine 3',5'-monophosphate (AMP) phosphodiesterase.
Fertil Steril. 1981 Dec;36(6):798-802.

Caffeine and other phosphodiesterase inhibitors are potent inhibitors of the promotional effect of TPA on morphological transformation of hamster embryo cells.
Cancer Lett. 1985 Aug;28(1):9-17.


Wasn't exactly sure what you were looking for in particular but to answer your question. Cyclic AMP (cAMP) acts as a cellular signalling molecule which transmits signals from the cell membrane to the interior of the cell and to the nucleus. Cyclic AMP is quickly metabolized by phosphodiesterases, ie, by enzymes which break the diester bond (two oxygen bonds) connecting the 5' carbon to the 3' carbon of the ribose between the phosphate forming the cycle. Caffeine is similar enough to adenine that it binds to phosphodiesterases, and it can inhibit phosphodiesterase molecules preventing them from hydrolyzing (inactivating) cAMP. Practically speaking, however, this effect occurs only modestly in the body because the amounts required for a significant effect are greater than the plasma levels of caffeine acheived by coffee-drinking.

Hope this helped
(back to the study )

 

[AndyzPsylocybes]

I strongly believe that if caffeine was found today it would be illegal.

 

[Jimmy the Gun]

what is phosphodiesterase?

 

[phase_dancer]

which one?

more info Here

They are enzymes involved in a variety of functions. In this role cAMP is hydrolysed by this class of enzymes. Looking above you'll notice several are invovled with cyclic AMP

 

[BigTrancer]

I think that asking such generalised questions as "what is phosphodiesterase?" in a thread that is directed such as this one, will send this thread far off course unless the answers are built into a large explanatory reply. If you are struggling with definitions or nomenclature, please feel free to make use of Google for basic information to place you in the context of this thread. That way the replies in the thread will be more likely to be on-topic and constructive to the discussion.

On the other hand, it could also be useful for the original poster to include said background information with their query... just to give the gentle reader some inkling as to where the question is leading from, to...

BigTrancer

 

[phase_dancer]

^^My fault as well. Above post fixed to minimise confusion.