Opioids Insufflating/Snorting Tapentadol (Nucynta/Palexia)

[Rybee]

Tapentadol is a relatively new semi-synthetic opioid, somewhat similar to Tramadol. Both have dual modeS of action as an agonist of the μ-opioid receptor as well as the ability to inhibit the reuptake of specific neurotransmitters. Whilst Tramadol's reuptake inhibition of Serotonin is relatively strong when compared to it's reuptake inhibition of Norepinephrine/Noradrenaline,¹ conversely, Tapentadol's reuptake inhibition of Norepinephrine/Noradrenaline is relatively strong when compared to it's reuptake inhibition of Serotonin.²³

When orally ingested, Tapentadol's analgesic properties come into effect within thirty-two minutes of,^[3] with an approximate half life of 4h,⁴ when compared to Tramadol's 6.5h half life.⁵⁶.

As for it's bioavailability, this is more contentious, with some sources suggesting 32%⁷-34%⁸ when orally ingested.

The Tapentadol I have are 100mg XR/SR/ER tablets with a duration of action lasting from 8-12h.⁹. As for equipotency, this puts it in line with approximately:
Oral Morphine: 40mg¹⁰, 40mg¹¹, 37mg¹²
Oral Oxycodone 20mg ¹⁰, 26.5mg,¹¹ 25mg¹²

I really like the effects of both Tramadol and Tapentadol as I find them to be very stimulating and buzzy for an opiate. I've never snorted Tramadol but was wondering whether anybody has snorted Tapentadol. Or if they haven't, what would they expect the effects to be from the information provided? Or has anybody insufflated Tramadol?

Not such a fan of snorting much, but as I said, I really enjoy both opiates. I've got loads so am not worried about wasting any.



Citations:

¹ Brayfield, A, ed. (14 November 2011). "Tapentadol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 2 April 2014.
² Now What? DEA Tosses Tramadol in Schedule IV, By Nadia Awad, MedPage Today, Jul 10, 2014
³ Leppert, W (November–December 2009). "Tramadol as an analgesic for mild to moderate cancer pain." (PDF). Pharmacological reports 61 (6): 978–92. doi:10.1016/s1734-1140(09)70159-8. PMID 20081232.
⁴ Brayfield, A, ed. (14 November 2011). "Tapentadol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 2 April 2014.
⁵ http://reference.medscape.com/drug/ultram-er-tramadol-343324#showall
⁶ http://www.drugs.com/ppa/tramadol-hydrochloride.html
⁷ Terlinden, R.; Ossig, J.; Fliegert, F.; Gohler, K. (2006). "Pharmacokinetics, Excretion and Metabolism of Tapentadol HCl, a Novel Centrally Acting Analgesic in Healthy Subjects". Program and Abstracts of the 25th Annual Scientific Meeting of the American Pain Society; May 3–6, 2006 San Antonio, Texas. Poster 689.
⁸ http://www.eperc.mcw.edu/EPERC/FastFactsIndex/ff_228.htm
⁹ Patient Information Leaflet
¹⁰ http://www.nhstaysideadtc.scot.nhs.uk/TAPG html/pdf docs/TAPENTADOL DOSE CONVERSION CHART FINAL.pdf
¹¹ http://www.globalrph.com/opioidconverter2.cgi
¹² http://agencymeddirectors.wa.gov/mobile.html

 

[poppyplanet]

I was prescribed Tramadol for about ten or so years. I never once snorted it because the thought of snorting an SNRI or even any other serotonin or norepinephrine type drug just doesn't sit well with me. They aren't made to work threw insufflation as far as I know. Now if Tramadol was strictly a plain opioid without any SNRI benefits, I would definitely try snorting it. I would highly suggest not snorting your Tapentadol. Good luck to whatever you do and report back to let us know you're ok and how well it worked. Again, it's not worth it in my opinion, it could cause potential health risks. I'm sure a moderator will eventually chime in to give you some better insight. Good luck.

 

[Friesthem]

Tapentadol is a relatively new semi-synthetic opioid, somewhat similar to Tramadol. Both have dual modeS of action as an agonist of the μ-opioid receptor as well as the ability to inhibit the reuptake of specific neurotransmitters. Whilst Tramadol's reuptake inhibition of Serotonin is relatively strong when compared to it's reuptake inhibition of Norepinephrine/Noradrenaline,¹ conversely, Tapentadol's reuptake inhibition of Norepinephrine/Noradrenaline is relatively strong when compared to it's reuptake inhibition of Serotonin.²³

When orally ingested, Tapentadol's analgesic properties come into effect within thirty-two minutes of,^[3] with an approximate half life of 4h,⁴ when compared to Tramadol's 6.5h half life.⁵⁶.

As for it's bioavailability, this is more contentious, with some sources suggesting 32%⁷-34%⁸ when orally ingested.

The Tapentadol I have are 100mg XR/SR/ER tablets with a duration of action lasting from 8-12h.⁹. As for equipotency, this puts it in line with approximately:
Oral Morphine: 40mg¹⁰, 40mg¹¹, 37mg¹²
Oral Oxycodone 20mg ¹⁰, 26.5mg,¹¹ 25mg¹²

I really like the effects of both Tramadol and Tapentadol as I find them to be very stimulating and buzzy for an opiate. I've never snorted Tramadol but was wondering whether anybody has snorted Tapentadol. Or if they haven't, what would they expect the effects to be from the information provided? Or has anybody insufflated Tramadol?

Not such a fan of snorting much, but as I said, I really enjoy both opiates. I've got loads so am not worried about wasting any.



Citations:

¹ Brayfield, A, ed. (14 November 2011). "Tapentadol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 2 April 2014.
² Now What? DEA Tosses Tramadol in Schedule IV, By Nadia Awad, MedPage Today, Jul 10, 2014
³ Leppert, W (November–December 2009). "Tramadol as an analgesic for mild to moderate cancer pain." (PDF). Pharmacological reports 61 (6): 978–92. doi:10.1016/s1734-1140(09)70159-8. PMID 20081232.
⁴ Brayfield, A, ed. (14 November 2011). "Tapentadol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 2 April 2014.
⁵ http://reference.medscape.com/drug/ultram-er-tramadol-343324#showall
⁶ http://www.drugs.com/ppa/tramadol-hydrochloride.html
⁷ Terlinden, R.; Ossig, J.; Fliegert, F.; Gohler, K. (2006). "Pharmacokinetics, Excretion and Metabolism of Tapentadol HCl, a Novel Centrally Acting Analgesic in Healthy Subjects". Program and Abstracts of the 25th Annual Scientific Meeting of the American Pain Society; May 3–6, 2006 San Antonio, Texas. Poster 689.
⁸ http://www.eperc.mcw.edu/EPERC/FastFactsIndex/ff_228.htm
⁹ Patient Information Leaflet
¹⁰ http://www.nhstaysideadtc.scot.nhs.uk/TAPG html/pdf docs/TAPENTADOL DOSE CONVERSION CHART FINAL.pdf
¹¹ http://www.globalrph.com/opioidconverter2.cgi
¹² http://agencymeddirectors.wa.gov/mobile.html

It burns worse than fire. A friend once told me. They survived lol. Severe pain for an hour or so because of burning sensation.

 

[supersonic89]

I don't think it's worth it. I have read many reports saying that it hurts a lot. There is a guy in Erowid that says that the effects are faster if you snort it, it does not mention if it is painful or not. Maybe the pills are from a different manufacturer.

Palexia and Nucynta are the same? I mean from the same manufacturer (laboratory)? In my country they are called Palexis.
I am also a heavy tramadol user and I liked tapentadol. Although I feel less stimulating than tramadol.

 

[Friesthem]

Don’t snort lol. Burns like a biatch. Unless you don’t care about that lol.
Rectal is way better, forget the B/A, but probably around double. Add an nmda antagonist like dxm, even just a little. You’ll be flying, so be careful. Take 1/3 dose or less of normal dose if going to try

 

[OpialiciouslyMe]

Tapentadol works fine enough orally anyway.
I find a 100mg instant release tab orally is as strong as a 20mg oxy as far as analgesia goes so I have never needed to take it any other way.
Tapentadol is much less a SNRI than tramadol. Negligibly so in fact and it's much better than tramadol as it's more potent.
It's not a well known opioid but it's pretty good I say. Better than oral morphine and WAY better than tramadol.

 

[supersonic89]

Don’t snort lol. Burns like a biatch. Unless you don’t care about that lol.
Rectal is way better, forget the B/A, but probably around double. Add an nmda antagonist like dxm, even just a little. You’ll be flying, so be careful. Take 1/3 dose or less of normal dose if going to try

I snorted sertraline once and that shit did hurt like hell. I doubt Tapentadol hurts more than that shit hahaha. Maybe I can try the rectal thing. This week or next I'll have some and see what happens.
I have always been struck by this kind of secret regarding the bioavailability of Tapentadol in other forms of non-oral administration.