Moderator: Music Discussion, PM
- Aug 31, 2016
- Frostbite Falls, MN
Psilocybe semilanceata found to powerfully inhibit MRSA
Nevase MC, Bhujbal DS, Tapkir PV, Jathar SB, Dhumal SR
MRSA is a type of bacterial infection that is resistant to widely used antibiotics. The full name of MRSA is meticillin-resistant staphylococcus aureus. Staph aureus is a common type of bacteria. It is often carried on the skin and inside the nostrils and throat, and can cause mild infections of the skin such as boils and impetigo. If staph bacteria gets into a break in the skin, they can cause life-threatening infections, such as blood poisoning or endocarditis.
MRSA is a skin infection that cannot be fixed with a medicine that kills bacteria called antibiotics. Because the bacteria cannot be killed with medicine, the infection will keep spreading, eventually reaching other areas of the body. And with nothing to stop the infection from spreading, MRSA can eventually kill the patient. That is why it is important that people know about MRSA, what it is, and what to look for.
Normally, Staph aureus is present on our skin, and if you get a cut, your body goes to work to defend itself against this bacteria. If you get a normal staph infection, antibiotics can kill the bacteria and you will be better in a few days. But with MRSA, the antibiotics do not work to kill the bacteria and that makes this kind of infection very dangerous.
S. aureus most commonly colonizes the anterior nares (the nostrils). The rest of the respiratory tract, open wounds, intravenous catheters, and the urinary tract are also potential sites for infection. Healthy individuals may carry MRSA asymptomatically for periods ranging from a few weeks to many years. Patients with compromised immune systems are at a significantly greater risk of symptomatic secondary infection. In most patients, MRSA can be detected by swabbing the nostrils and isolating the bacteria found inside.
MRSA may progress substantially within 24–48 hours of initial symptoms. After 72 hours, MRSA can take hold in human tissues and eventually become resistant to treatment. The initial presentation of MRSA is small red bumps that resemble pimples, spider bites, or boils that may be accompanied by fever and, occasionally, rashes. Within a few days, the bumps become larger and more painful; they eventually open into deep, puss-filled boils. About 75% of community-associated (CA-) MRSA infections are localized to skin and soft tissue and usually can be treated effectively.
Some CA-MRSA strains display enhanced virulence, spreading more rapidly, and causing illness much more severe than traditional HA- MRSA infections, and they can affect vital organs and lead to widespread infection (sepsis),toxic shock syndrome, and necrotizing ("flesh-eating") pneumonia. This is thought to be due to toxins carried by CA-MRSA strains, such as PVL and PSM. It is not known why some healthy people develop CA-MRSA skin infections that are treatable while others infected with the same strain develop severe infections or die.
People are very commonly colonized with CA-MRSA and are completely asymptomatic. The most common manifestations of CA-MRSA are simple skin infections, such as impetigo, boils, abscesses, folliculitis and cellulitis. Rarer, but more serious, manifestations can occur, such as necrotizing fasciitis and pyomyositis, necrotizing pneumonia, infective endocarditis, and severe bone and joint infections. CA-MRSA often results in abscess formation that requires incision and drainage.
The psychedelic mushroom Psilocybe semilanceata has been shown to strongly inhibit the growth of Staph aureus. Studies have also shown CBD and CBG to powerfully inhibit MRSA.