- May 3, 2014
^ I found a couple articles about increasing the BA% of Buprenorphine PO with P450(CYP3A4) and UGT inhibitors
The above study focuses on a potent 3A4 inhibitor
However, with (preferably White) Grapefruit Juice and ~800mg Cimetidine, you could increase Oral BA% 5-10 fold, and slightly improve Sublingual (SL) BA; it would also enhance IV/IM admistration
I got the idea because hitting veins has become absurdly difficult most of the time, and muscle shots hurt for days because I am just so thin
I just thought this was worth mentioning, they say 90% of a dose of Buprenorphine is absorbed, so if you blocked intestinal (pre hepatic extraction) and First Pass Hepatic extraction, you could reach 50-70%, so it would seem.
May post another study later, just thought I would focus on the 3A4 inhibitors as they are easier to get
Good Morning BL'ers