⫸STICKY⫷ I Like to Draw Pictures of Random Molecules

Hodor

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For example, exposure to acids like HCl can result in hydrohalogenations (turning the alkene into a saturated haloalkane)
Actually, looking at the structures of 5-Cl-ADB-A and comparing it to that of regular 5-Cl-ADB, it looks like what they did was the opposite of the reaction mentioned above: They first made the compound with a chloropentyl chain on it, then treated it with a very strong base in order to achieve a dehydrohalogenation, i.e. the removal of HX (X = any halogen) from a haloalkane to turn it into an alkene.

Still, even if you only did it at the very end, that's an extra reaction step compared to regular 5-Cl-ADB... and there's always the risk of side-reactions (although these can usually be minimized by using a very bulky base that can attack the protons on the exposed alkyl chain of the molecule, but not the carbonyls of the ester and amide groups).
 

sekio

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most hydrohalogenations need to be run with anhydrous HCl to be effective as the covalent species H-Cl is not present in a high enough concentration in aqueous solutions (being a strong acid, it dissociates completely to H₃O+ and Cl-)

alkenes are actually pretty unreactive, save for some exotic conditions (MnO4-, OsO4, dihalogens, Hg2+, ozone, Pd/O2 (wacker))
 

Dresden

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For computational chemistry and x-ray crystallography, ball and stick figures may be necessary; but, for the organic chemist, Kekule structures are *the* Au standard.
 

blueberries

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Jan 13, 2011
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I call this one DOP!
Nothing to do with opiates but it could use a little work with nomenclature!

I prefer the 3D versions thats what they actually look like after all

View attachment 11372
No offence but I can hardly understand what's going on here, could you make this a flat drawing so I can figure it out?!
PS: I realise that some habits can't be helped but I really wouldn't mind finding out the structure!
 

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Gaffy

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With DMT being investigated to suppress "voices" in Skizo patients and H1 being a general antipsychotic, maybe these could be antidepressive antipsychotics, give me a try I'd say! with chlorphenamine being well supported as a downer (sold with Ephedrine in France), it's widely used as a somniferum.





Would mixing and heating too much methanol with tyrosine make 4-methoxy Methoxyphenylalanine? Tyrosine on itsef is a bit boring.
 
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JacksinPA

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Jan 20, 2018
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BUNODOSINE 391

Isolated from a sea anemone, this N-acylamino acid is a potent analgesic. Its effects are not reversed by naloxone but are reversed by serotonin receptor antagonists. Interesting lead for discovery work in the area of non-opioid analgesics. It would be interesting to evaluate the effects of different substituents on the indole & histidine nuclei. The occurence of this molecule in such an early life form may indicate a basic evolutionary role in nerve function.

It is interesting to note that 5-brominated tryptophan residues are found in so-called 'sleep peptides' produced by some cone snail species. These are 'post-translational' enzymatic modifications of the tryptophan residues in these peptides, the enzyme involved being a bromoperoxidase & the reaction mechanism being free-radical in nature. The key raw material is bromide ion, which is abundant in seawater.
 

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Dresden

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What does ethylamphetamine feel like in comparison to amphetamine or methamphetamine? Dosage? Duration? Any 5-HT2a agonism?



2-ethylamino-1-phenylpropane
N-ethyl-amphetanine
Ethylamphetamine
ETH
 
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