There is no such thing as an "N-ethyl ester". Condensation of an acid with an amine forms an amide.Would it be possible to make simple pro-drugs like esters from gabapentinoids such as pregabalin? For example an N-ethyl ester similar to theanine or a nicotinoyl-ester similar to picamilon.
Why inositol of all things, though? Inositol has a greater molar mass than pregabalin itself, and it is hydrophilic as hell, so its bioavailability might actually be worse.Could those inositol-esters make sense as a pro-drug?
Compared to benzodiazepines, pregabalin's recreational potential is far lower. Also, one of the problems with gabapentinoids is that their structure-activity-relationship is still not all that well-understood. Gabapentinoids apparently need to be actively transported into the brain via special amino acid carrier proteins. For years, the search for a successor to pregabalin has been slowed down by the fact that compounds that seemed much more potent in the in-vitro binding assays showed little if any increase in in-vivo potency, as their structural modifications would also decrease affinity for the aforementioned amino acid carriers, no longer justifying the significantly more complex synthesis.(Pregabaline is at the moment just a normal-prescription medicine and no narcotic/very controlled substance so the esters would be legal in most countries, also it's quite cheap and easy to produce and has massive recreational potential and gained a lot of popularity over the last years, why not making RC-analogues of gabapentinoids, at least they're a class of drugs with relative low toxicity and huge medicinal and recreational windows/safety).