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Tryptamines HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca

Cosmic Charlie

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you're banging 65mg and didn't notice it much due to the xanax... ? what?

I must have read wrong xD what was yesterday's dose?

No the other nite I did like 50mgs and I did feel it more than this for damn sure and had visuals and was on Xanax. Any talk of IV use was related to 4-AcO-DMT I have never shot DMT before but if I had some made synthetically I deff would. The most AcO I have ever injected was 75mgs and I had an overwhelming breakthru, would not repeat.
 

Cosmic Charlie

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So it doesn't work then...

I dunno right now man maybe not, I let it sit in the water like 5 mins after that pic was taken and then held it under my tongue for 15mins and it sorta burned wasn't very pleasant. I'm kinda surprised cuz even when I have a high tolerance if I vaped a bunch of DMT like that I would have more effects than this. And that is good DMT I and others have broken thru with it.
 

Snafu of the Forest

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No the other nite I did like 50mgs and I did feel it more than this for damn sure and had visuals and was on Xanax. Any talk of IV use was related to 4-AcO-DMT I have never shot DMT before but if I had some made synthetically I deff would. The most AcO I have ever injected was 75mgs and I had an overwhelming breakthru, would not repeat.

that's crazy to me man, and you're using IV?

by smoking - 65mg was my "breakthrough" point - where I would talk to uncle fester aliens and shit

pretty much smoking 50mg or more was really fucking intense, but 65mg was my special point, my breakthrough dose. if I really wanted to push it i'd smoke 80mg

I was always smoking my own DMT extraction, pure white fluff, was very good stuff - no yellow or orange or anything.
 

Snafu of the Forest

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No I vape DMT always.

I've used 4-AcO-DMT IV many times tho, which feels pretty much identical to vaped DMT.

You know after doing a lot of DMT and then doing a lot of mushrooms I started to notice some big similarities in mushroom visuals. I'm not surprised. In fact usually when I'd look at myself in the mirror on mushrooms I would have very DMT like visuals (in a very DMT like way - not talking about my body)

Never done 4-Aco myself
 

Cosmic Charlie

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I mean when you push the plunger down a few seconds later IV 4-AcO-DMT is exactly like what it feels like when you exhale your third hit of deemsters. It's really wild the last time I went way to far tho and I couldn't even navigate my apartment properly,. Considering i live in a fucking studio that is concerning, lol. It wasn't a bad trip per say bit I just didn't gain much from it in the 25-30mgs IV AcO range It's much more useful IMO. It was just my birthday and I was feeling adventurous, I was also doing speedballs the whole nite leading up to the trip Cocaine Hcl/FentaDope not the healthiest bender. Was one of the last times I used narcotics.
 

tregar

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The point I'm trying to make, and the reason I put this in the psychedelics experience section & not the pharmaceutical section of bluelight...is that the combination of the two (oral THH taken 1 hour earlier) and sublingual under the tongue DMT for 15 minutes results in the "full monty", will give you an experience like strong cactus tea or true Ayahuasca, the full mind expansion transcendence. This is what a lot of people don't understand, is that Ayahuasca is teamwork between the various alkaloids.

Tetrahydroharmine was called by one researcher "the tryptamine of the beta-carboline world" to give an example of its remarkable visionary properties. It's an isomer of a hormonal-like compound found in the brain naturally, it's what gives Ayahuasca is telapathine or telethapy properties and hours of dream-like realistic closed eye visionary visions.

I've taken 300mg of THH on it's own many times and for hours with eyes closed I view endless dream-like visions, like slow and high speed movies being played for 2 hours, the detail is way beyond 4k, mind-blowing vistas...totally unlike normal dreams, it seems to tap into the "Archaic record" of the universe, where all events, past, present, and future are stored...it shows you artwork, architecture, nature, culture, fantasy, history, the future, spiritual, supernatural. The visions are also characterized by the extraordinary beauty that they manifest.

DMT according to two studies posted in part 2 does not block serotonin on it's own, but THH does (like ibogaine, cactus, LSD, mushrooms), serotonin blocking results in stimulation and the breaking down of the survival filters or barriers in the mind, the combination of the two results in not just 20% receptor stimulation from the DMT alone, but 100% receptor stimulation, as 5-ht1a inhibition (serotonin blockage) makes up over 80% of brain 5-ht according to LSD scientist Dr. Nichols. Tetrahydroharmine has also been shown to agonize the A2A-A2C receptors, just like mescaline, they have numerous receptorome similarities.

You will notice with the combination of the two that music sounds incredible, closed eye visions are seen like those of "true Ayahuasca" described in "Antipodes of the Mind" by Benny Shanon, or cactus tea. Open eyed beauty is profound, impossible neon colors not seen on this earth become apparent.

Last night with a combination 250mg oral tetrahydroharmine dosage, and sublingual HPBCD DMT dosage of 50mg, when I waved my hand, I saw colored fractals inside the tracers. The duration is long with the sublingual DMT, it comes on in 1/2 the time of an oral dose, and you need much less of the drug than what is needed orally with a RIMA. One of the best parts is that I experience no nausea.

Out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + sublingual HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.
 
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tregar

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redgreenvines said:
well you can mix me up a batch
I would love too! But since I can't just buy some HPBCD powder, dirt cheap.

Ferdinando said:
mescaline is a second
Full bodied cactus tea from 1 x 12" bridgesii or 2 x 12" medium thickness to 1 x 12" large thickness San Pedro is my absolute favorite, have done over 90 times now over many years, totally bad ass. The 250mg oral THH + 30mg on up sublingual HPBCD DMT ranks in the same, both equally VERY bad ass. I keep a trip diary over a period of many years. I've done Ayahuasca x 70 times now.

Tyrannicalrex said:
I'm about to try cactus/mesc extraction HcL more than likely. I have a couple kilos of MHRB, probably a lifetime supply, lol. I could get 36 grams of DMT from them give or take.
Tell you what, just cut the cactus down the sides (de-core it), cut into chunks, peel the skin off each chunck, and boil the pieces for 1 hour, then strain thru a strainer and drink--so easy and kicks much ass--full bodied complete spectrum. Also, so glad to hear you have a lifetime supply of MHRB.
 
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tregar

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1) For the HPBCD DMT experiments, prefer using "clean DMT" or DMT that has been cleaned using a sodium carbonate wash, procedure below:

2) PKA of DMT is 8.75 or so, so please do not use a sodium bicarbonate wash -- it will eat up most of your DMT, as ph of bicarb is not high enough, it needs to be 1 to 2 points higher than PKA of DMT, at 11 or 11.5 or so is perfect, where 100% sodium carbonate PH is at, found in pool isle of home box store.

3) As performing a "sodium carbonate wash" on crystals AFTER they are freeze precipitated is a pain in the ass, will attempt to perform a sodium carbonate wash in real time this time, immediately on the 1st pull, and every pull thereafter.

4) For example, a procedure which yields 1.5g DMT from 150 gram powdered bark: the first pull is using 75ml naptha on 150g powdered bark mixed into 1.7 liter lye water (1.5 x 150g bark = use 225g lye dissolved into the 1.7 liter 150 degree hot water by slowly sprinkling in lye using safety goggles and long chemical resistant gloves that go up each arm, and standing back as far as possible...the hot water will fizz but not boil up) in a 2 Liter erlenmeyer flask (.5 x 150g bark = use 75ml naptha pull for each of the 4 pulls). An erlenmeyer flask makes it easy to do pulls using a long glass pipette, as the top of flask is tapered, so all the naptha collects at the top for easy pull.

Use an electronic thermometer to check the temp of the Lye water bark mix, when the lye water cools down from 150 degree F to around 115 to 110 degree F, then it's time to add your 75ml of naptha, make sure your 2L flask is sitting on a mitten or similar...this makes it easy to swirl your flask to mix the contents, make sure you are using the proper rubber stopper number to seal the top of your flask once you turn it upside down then right side up to mix the contents as well.

Prefer to do a combination of swirling and a couple of upside down then right side up turns of the 2L flask, then once right side up, let the rubber stopper out, and let the stopper just barely sit in the flask (not tight), so gasses can exit. After 1/2 hour, all the 75ml of naptha will migrate & collect at the top of the tapered erlenmeyer flask...use your long glass pipette to collect the naptha, that's it! very easy, no mess, and the tapered erlenmeyer flask and glass pipette with round rubber plunger at the end makes it easy to collect the naptha at the top without collecting any lye water by accident. This is the way a real chemist would do it.

to clean...then use 1/4 of the amount of each naptha pull or (0.25 x 75ml pull = use 19ml of warm water at 100 degree F with a dash of sodium carbonate dissolved into it) till ph = 11 to 11.5 of the wash water.

5) So then add the 75ml saturated naptha bark pull into a sep funnel, add 19ml of warm (100 degree F) sodium carbonate solution, and shake & swirl it all together in the sep funnel for 5 seconds, then separate off the bottom layer which will be the sodium carbonate water and dispose of it, and let out the top layer of sodium carbonate washed clean naptha into a 1/2 pint jar, put lid on jar, place in freezer, and freeze precipitate overnight, and collect clean crystals in morning by pouring over a coffee filter attached to a 1/2 pint wide jar with rubber band.
 
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SKL

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Dude, try it with and without THH, and both of those with and without HPBCD. Put up or shut up.
 

tregar

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Tomorrow I will be hitting two elves with one stone. I will take not only 70mg of HPBCD DMT orally with 200mg harmine + 250mg tetrahydroharmine orally all dissolved into a hot tea with some crushed vitamin C to dissolve the harmalas, and report back to see if the experience is similar to using an actual Hawaiian psychotria brew (which is always VERY kick ass super strong, all encompassing & very neon colorful with tracers that go onto infinity)...but after it wears off I will then take 30mg on up of sublingual HPBCD DMT to extend the trip, and bring back 60 to 90 minutes of DMT activity.

message to me:
What is the point of that procedure anyway to make an edible version of dmt?
This thread shows how to make in 30 seconds what is called HPBCD DMT, using only a spoon, some HPBCD powder, some DMT, and drops of water.

When you for example make a hot tea with some crushed vitamin C to help dissolve the harmine and thh, and add 180 to 230mg harmine to the tea, along with 150 to 250mg of tetrahydroharmine to the tea, and also add 70mg of HPBCD complexed DMT to the hot tea, it could give you a powerful Ayahuasca experience that is VERY similar to using an actual hawaiian psychotria brew, far more powerful and all encompassing than using 70mg of freebase DMT or 70mg of freebase salt formed from fumarate or DMT salt made by dropping DMT freebase into coca cola or orange juice, etc.

What we are beginning to discover is this: The HPBCD "encapsulated and trapped DMT" theoretically could be forming enhanced modes of transport and delivery of DMT similar to how oral psychotria leaf gives an experience that is much more powerful and all encompassing and colorful than using normal plain DMT crystals.

The experiences from the Hawaiian psychotria brew Ayahuasca tea are always +4 to +5 on the Shulgin scale for myself in over 70 Ayahuasca sessions, while multiple experiments with several people in the Clearlight sessions found the DMT extracted crystals gave only mild experiences (+3 max) even when using doses up to 100mg.

I myself even used doses of oral dmt crystals at doses from 70 to 120mg, and found them all mild as well (+3 Shulgin scale) compared to the VERY strong Hawaiian psychotria experiences (30 to 35 gram tea), just like mind-blowing Jungle Ayahuasca.

Clearlight:
Experiments that involved several people found the leaf brew form superior to extracted actives, the leaf brews were very strong and powerful & clairavoyant (+5 Shulgin scale), while the extracted actives were mild (+3 Shulgin scale) at best, even up to 100mg. Again, this is poorly understood.

However, the HPBCD complexed DMT seems to greatly alter the transport, absorption & digestion of DMT freebase crystals, resulting in powerful experiences sublingually so far, perhaps even resulting in oral powerful Ayahuasca similar to those brews using actual Hawaiian psychotria leaf in them.

downwardsfromzero wrote:
This combined with the HPBCD complexation results (which we really ought to replicate and confirm) makes me wonder whether there are saccharides in leaf brews which perform a similar effect to HPBCD. There is still so much scope for really interesting research here -thanks for posting.
This is indeed fascinating downwardsfromzero, thanks for that keen observation on the sacchardies, perhaps they do function similar to HPBCD? Note: this procedure will work with any freebase molecule that is poorly water soluble, it does not work with already water soluble compounds or salts.

Jagube said:
I've seen anecdotal reports of quidded D. cabrerana leaf being active.
Excellent observation Jagube.

69ron posted 8/12/2009:
People are getting pleasant DMT effects from sublingual Virola calophylla resin. I don't think it has that much DMT in it. So why does the resin work so well when DMT is so hard to use sublingually?

HPBCD DMT is very strong...I even used 30mg of it sublingually under tongue for 15 minutes and experienced rapid heartbeat & pulse, tryptamine body rush & buzz, dilated pupils, music sounded incredible, had cev's and open eyed euphoria and profound beauty. I took 250mg of tetrahydroharmine 1 hour earlier so it was more like a true Ayahuasca experience, but no nausea.
 

tregar

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I bought my 1kg tub from a supplier of sports supplements 12 years ago, as it was sold right along side pro-hormones which converted to testosterone in the body at a rate of 95% compared to testosterone alone, as you guessed, all pro-hormones like 4-androstenediol were all later banned.

I've been a weight lifter/bodybuilder since my early 20's when I was a full time lifeguard on the beach (love the water, water spirit)...currently my bodyweight is 220lbs at 12 percent bodyfat, follow a strict Palumbo high-protein keto-diet daily for years, 1.2 grams protein per lb of bodyweight per day. I get all my meals and 65 gram protein shake within an 8 hour window everyday (6am till 3pm), and fast after 3pm till I wake up the next day. This keeps my bodyfat low yet retains all the muscle. I run on the treadmill during the fasting period once I get home for 20 to 30 minutes at least 3 times a week. I take bcaa's before I hop on treadmill to keep any muscle from breaking down.

Even at this weight, I still find that 200mg of harmine completely inhibits the monoamine oxidase in my body...in all of my 70 Ayahuasca experiences using 200mg harmine + 220 to 250mg tetrahydroharmine over many years, I find the alkaloid amounts to completely activate 30 to 35 grams of Hawaiian psychotria to the full extent.

Later tonight I will take 200mg harmine + 250mg tetrahydroharmine + 70mg HPBCD DMT (490mg HPBCD powder kneaded, crushed & stirred for 30 seconds into 70mg DMT on a spoon with many drops of water forming a sticky complex for the oral use)...I will report back. Several papers I have read indicate that HPBCD complexed pharmaceuticals even when delivered orally out-performed normal oral versions of themselves by many factors.

I always mix everything together into a 2oz hot water tea with a dash of crushed vitamin C to dissolve the freebase harmine and THH, along with the HPBCD DMT, stir all together well in the hot water tea, just as the Shaman's do, take all together at exact same time, works incredibly well, far better than spacing out the DMT from the harmalas, I should know, I ran several experiments years ago, and the tea where ALL was mixed together outperformed all the other trials consistently.
 
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tregar

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Here is the HPBCD DMT solution ready to go for tonight

1. Materials: 70mg DMT for oral use, 490mg HPBCD, 1ml pipette, 0.25 to 0.50ml VERY HOT water from a nearby microwaved coffee cup of hot water.

2. Made a 1:1 molar ratio (1:7 mg ratio) of host drug DMT to HPBCD by adding 70mg of DMT onto spoon, added 490mg of HPBCD on top DMT, add 0.500 ml of VERY HOT near boiling water (10 drops) drawn up with pipette from microwaved water in coffee cup. For sublingual use don't overdo the drops, 0.250ml of water (5 drops) is plenty...if you accidentally add too much water then run a fan over spoon to evaporate some of it off.

Knead, mash and stir it all together for 2 minutes using the end of a spoon, notice the two separate powders turn into a homogenous transparent solution when done mashing.

3. For oral use, add the spoon of HPBCD DMT water to 2oz of hot water (120 degree F), it will all dissolve instantly into a totally clear homogenous solution, take PH of water, it is safe to drink at ph=8 to 9.

4. Store in fridge till later, when ready heat water back up in a pyrex dish on stove to 110 degree F or so, add 200mg harmine + 150 to 250mg tetrahydroharmine, stir all together and consume in dreams, just the way the Shaman's do it, take it ALL mixed together, works incredibly well this way, have over 70 experiences with Ayahuasca over many years.

5. Several papers I have read indicated that HPBCD complexed pharmaceuticals even when delivered orally out-performed normal oral versions of themselves by many factors.

With the Ayahuasca journey, she guides you to the existence of a higher spiritual plane...recognized to which insight can and must be gained, yet it does not reject the mundane reality as inferior or empty. This joyous embracement of the world of form leads to words like profound pleasure, beauty and joy. This loving reappraisal of the worldly forms leads the way to higher divine planes.

Last pic: beautiful Shaman woman

Pics here: HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca - Pharmahuasca - Welcome to the DMT-Nexus
 
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tregar

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------------------------------------
Part 10: 70mg DMT complexed to 490mg HPBCD oral Ayahuasca report, +5 Shulgin scale
------------------------------------

The experiment was a success...I took the 70mg DMT complexed to 490mg of HPBCD all kneaded/crushed using end of another spoon...and mixed on a spoon for 2 minutes with 0.500 milliliter of VERY HOT near boiling water (around 10 drops of water). What I do is heat up a bit of water in a coffee cup in microwave & draw up drops of it using pipette. I read using hot water speeds & aids the mixing of the HPBCD to host drug.

I added the 0.5ml spoon full completely clear HPBCD DMT solution to 2oz of 120 degree hot water...this then immediately turned into 100% transparent water when it hit the hot liquid in the pyrex cup...This was stored in fridge until use...then when I was ready, the 2oz clear transparent liquid HPBCD DMT water solution, once re-heated up in pyrex pot on stove, to this was then added 200mg harmine + 250mg THH and also 150mg of pure ascorbic acid (vit C) to help dissolve the freebase harmine + thh.

I gulped it down in one shot...there was virtually no taste! I think the HPBCD completely masked the taste of the nasty DMT...I was shocked...took it all together at same time at 3:30, I'm writing this 3 hours later.

It came on exactly like 30 grams of hawaiian psychotria! there was no difference between this and the leaf brew, again I was shocked...it gripped me powerfully, heavy tryptamine buzz and high frequency, The THH already imparts a body frequency buzz + DMT tryptamine buzz = amazing amplified body frequency.

A vibrating neon colored fortress like a magnetic field surrounded me in the room, it shined off of every object similar to a UV blacklight glow...this neon visual vibration appeared all around me, given off by everything around me. The vibrational frequency field reminded me of the tractor beam in Star Trek when they would transport. I've experienced this same phenomena with past journeys involving 30 to 35 grams of potent Hawaiian psychotria...but never with plain freebase DMT or DMT salts before, only again with this HPBCD DMT.

I had to remain in one spot sitting as it was so strong for 1 hour straight, the walls in the room filled with 3-D ish like honeycomb orange & brown geometrics that appeared to bulge slightly off the surface, like the inside of a bee hive, neon colors were abundant, heavy tracers...the beauty all around me was infinite, beautiful CEV's (spinning and dancing or constantly morphing geometrics) and OEV...I was amazed to say the least.

During the oral Ayahuasca journey described above (200mg harmine + 250mg THH + 70mg DMT complexed to 490mg HPBCD) for the first hour, all objects glowed or shined as if in caught in a neon colored magnetic transporter beam.

In conclusion, I am impressed with this route of administration via sublingual or oral.
 
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tregar

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------------------------------------
Part 11: 35mg DMT complexed to 245mg HPBCD sublingual report
------------------------------------

Update at 8pm 5/12/21 around 5 hours later same night, the 250mg 10.5 hour half-life tetrahydroharmine (THH) was still active in my body.

Took sublingual 35mg DMT complexed to 245mg HPBCD on a spoon with less than 0.25ml (only 5 drops) of VERY HOT near boiling water, this was using water that was pre-heated up in microwave in coffee cup, then taken up with end of pipette, and dropped onto spoon with the HPBCD powder/DMT crystals. I kneaded, mashed & mixed it all together using end of a spoon for 2 minutes.

It ALL dissolved into a clear sticky solution after mashing it with end of spoon for 2 minutes--I drew it up from spoon using pipette and placed drops under tongue. It felt like all the DMT dissolved into bloodstream, experienced great effects held under tongue for 15 minutes--sweet taste, as the outer shell of HPBCD is formed from a sugar molecule--no burn! It mostly masked the taste of the nasty DMT.

5 minutes after the 15 minute sublingual period, my heart rate & pulse greatly increased, pupils dilated when I looked in mirror, had colored CEV visuals and long CEV lingering after images, open eyed beauty was profound, music sounded incredible once again, felt euphoria and elation. Zero nausea.

Highly recommend complexing DMT to HPBCD for oral use, which simulates actual very strong (+5 Shulgin scale) hawaiian psychotria leaf brew imho, as I've had over 70 hawaiian psychotria + Caapi journeys in the past over many years, or for sublingual use. The HPBCD complexed DMT imho absorbs many factors better than plain DMT freebase or DMT salts in the body, as I have over a dozen experiences with the oral freebase and DMT formed salts in the past for oral use (all only +3 on Shulgin scale). I was blown away by the oral & sublingual HPBCD DMT.

Oral use: 1:1 molar ratio of host drug DMT to HPBCD powder = 1:7 DMT to HPBCD mg weight ratio (70mg DMT to 490mg HPBCD)

SublinguaL: 1:1 molar ratio of host drug DMT to HPBCD powder = 1:7 DMT to HPBCD mg weight ratio (35mg DMT to 245mg HPBCD)

245mg of HPBCD powder may look like alot when laid out, but when even just a few drops of hot water is added to it, it shrinks into a tiny sticky mass as it is derived from a sugar molecule, perfect for "under the tongue" use.

Highly recommend HPBCD complexed DMT.

Pics of steps: https://www.dmt-nexus.me/forum/default.aspx?g=posts&m=1104614&#post1104614
 
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tregar

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HPBCD is itself very soluble in water (greater than 1000 mg/ml at room temperature). This increases with VERY HOT near boiling water. So now you see how I used 70mg DMT to 490mg HPBCD in 10 drops for oral use...or the 40mg DMT to 280mg HPBCD in 5 drops very hot water I used for sublingual use.

For example, if one were do an experiment to simulate oral Ayahuasca by complexing 670mg of HPBCD powder to 65mg harmine (1/3rd of an oral dose should work fine) + 40mg DMT all together on a single spoon for "under the tongue" sublingual use in order to avoid the dizziness of using say oral harmine, (along with 150 to 250mg THH taken orally 1 hour earlier which causes me no nausea or dizziness)...

...this may look like alot when laid out on spoon, but once you add between 5 and 10 drops of very hot near boiling water from a pipette taken up from a nearby coffee mug, the HPBCD shrinks into a tiny sticky clear mass as it is derived from a sugar molecule, perfect for "under the tongue" use. After 2 minutes or so of kneading and mashing all on the spoon using the end of another spoon with the drops of hot water, it forms a TRANSPARENT CLEAR solution.

P.S. I feel great next 2 days. No hangover, cactus trips are great but usually I feel a bit tired the next day, I feel no tiredness from the oral 200mg harmine + 250mg THH + 70mg dmt complexed to 490mg HPBCD oral journey...the trip is strong for 90 minutes, 3 hours total or so...THH leaves a great afterglow next day.
 
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