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How much metformin to inhibit mTOR?

Swim15

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Sep 11, 2016
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Just curious if anyone has found literature because I couldn’t dig any up on doses. Google is getting shittier by the day on search results.
 

Genetic Freak

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Just curious if anyone has found literature because I couldn’t dig any up on doses. Google is getting shittier by the day on search results.
I was of the opinion metformin (1g, PM, taken with 500mg resveratrol) primarily worked on AMPK (although I am aware mitochondrial complex I is inhibited by metformin leading to the AMPK dependent activation of TSC2 which inhibits mTOR in a roundabout way)...

mTOR is increased by L-leucine and inhibited by rapamycin (2-6mg every 2-5 days, or 5mg once a week) although not advised due to potential harms...
 

Swim15

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Thanks Genetic Freak! That’s what I was looking for and all of that sounds spot on. Appreciate it
 

Genetic Freak

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Thanks Genetic Freak! That’s what I was looking for and all of that sounds spot on. Appreciate it
Out of interest what are you trying to achieve..?

I have spoken with local GP recently about metformin for longevity via modulation of AMPK signalling, but decided against it due to potential side effects..
 

Swim15

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Honestly not really anything per se. Just been doing a lot of reading on aging, disease and disease pathology, and related stuff. Couldn’t really find info on it and was just wondering. Leaning about the different signaling pathways.

If a 500 ER was enough I might do one at night but have too many GI issues with UC right now anyways. Been a while but iirc doesn’t berberine work through a related signaling pathway potentially? Need to look myself
 

Genetic Freak

Moderator: SIED
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Joined
Mar 18, 2012
Messages
2,448
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New Zealand
Honestly not really anything per se. Just been doing a lot of reading on aging, disease and disease pathology, and related stuff. Couldn’t really find info on it and was just wondering. Leaning about the different signaling pathways.

If a 500 ER was enough I might do one at night but have too many GI issues with UC right now anyways. Been a while but iirc doesn’t berberine work through a related signaling pathway potentially? Need to look myself
AMPK
Sirtuins
mTOR, IGF-1

Have you been following the work of Dr David Sinclair..?
 
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