Bupe How long does IV buprenorphine take to kick in?

NeoLid

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I usually snort my subs, but decided to to try iv. I did 9mg (15mg snorted is my usual dose) its been about 20 minutes and im barely feeling anything. I read somewhere even IVed it can take up to an hour to kick in. So did I just fuck up my shot or is it gonna kick in a bit. Ill find out soon.

But my real question is if it does take an hour to kick in why is that, isnt iv supposed kick in within a few seconds for any drug?
 

Stargazer

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3 mins at most. It can take up to 30mins for full effect, but you feel it quickly
 

JessFR

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I dunno about bupe, I've never IVed bupe. Actually I've never taken bupe for maintainence therapy at all, just methadone. But with any other drug I've IVed the results have always been immediate. Maybe a couple seconds delay at most.
 

Captain.Heroin

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~ 1-3 minutes, please please please don't use such a high dose. Sometimes quicker? Been so many years.

If you're truly in withdrawal the first dose might not be felt, a second one is kind of necessary (or "double up" but I was not accustomed to doing that; hindsight is always 20/20); at the time my doses were < 1mg.
 

axe battler

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Captain H. When you were using doses of less than 1mg, did you find euphoria with these doses, even with daily dosing? I remember your bupe taper with low IV doses.
Was this because you got pleasant effects daily, or did you just have trouble giving up the needle?
Currently on 80mg methadone daily and the positive effects have finally run their course after about a year.
I'm considering reducing and going on subutex, not IV, but on a low dose, as I've heard this can be more effective for pain (both physical and imagined).
Cheers!
 

opiatekrzy

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When I shoot subutex, I feel a rush within 10 seconds. When I shoot Suboxone, I get no rush, and don't feel any effects for about 10mins. I don't care what anyone says about the naloxone argument in Suboxone, whether the bupe affinity is higher then naloxone or not, the naloxone sure as fuck still impacts the effects of Suboxone. No it's not a placebo, I been a hard core drug addict for twenty years..it sounds real good saying naloxone is just a deterrent in Suboxone to make addicts think twice before shooting , or that it's patented or whatever.

But yes, iv bupe kicks in pretty fast
 

JessFR

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When I shoot subutex, I feel a rush within 10 seconds. When I shoot Suboxone, I get no rush, and don't feel any effects for about 10mins. I don't care what anyone says about the naloxone argument in Suboxone, whether the bupe affinity is higher then naloxone or not, the naloxone sure as fuck still impacts the effects of Suboxone. No it's not a placebo, I been a hard core drug addict for twenty years..it sounds real good saying naloxone is just a deterrent in Suboxone to make addicts think twice before shooting , or that it's patented or whatever.

But yes, iv bupe kicks in pretty fast
Interesting. I wonder what the pharmacological reason is.

I believe you, I just wonder what the explanation is. Far as we know bupe does have a much higher binding affinity, it's strange.
 

opiatekrzy

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It's also strange how widespread people who have done it like me, all agree and feel the same way, kind of funny how Subutex prices on my area are higher then Suboxone prices... I guess I must be some special human with special powers.

jessFR- are you speaking from personal experience? Or are you just reading book smarts? Because you can ask any other human being that uses buprenorphine. Wait I suppose now is the time where you are going to say how an addicts mind and placebo is such a power thing? 20yrs of drug use i think I know what is real and what is not. I don't mean to come off like an asshole, but I knew this debate would come up the second I mentioned it. That's my half a penny
 

g0to

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Personal experience is just another name for "anecdotal evidence", something doesn't hold much weight if we're looking for true "evidence" aka proof that a hypothesis is correct. I used bupe for over 5 years on and off and for 2 years straight IV. I honestly can't tell a difference between suboxone and subutex. This was however with bupe as my only opiate, I never really switched back and forth or anything like that once I got on subs (preferred them because they were much cheaper and easier to get and it was nice knowing exactly the dosage I was gonna get, I was tired of the whole merry go round wrt street heroin). I preferred the suboxone strips because they were packaged/sterile and that was important to me since I was gonna be prepping them for IV.

Most people that abuse subs dont IV them, they sniff them. For that reason alone those small 8mg subutex with the arrow(?) on them were more rare and sold for more. They are the best ones to sniff, due to the small amount of powder. Generic suboxone pills are huge and most people don't know that breaking down a strip into water and spray the liquid up your nose "works" as there is a bit of prep involved and the technique to holding the liquid in your nasal cavity for a bit of time can be tricky to learn, with wasted drugs on the line if you fuck it up.

I believe there's genetic differences, even if bupe has a higher affinity than naloxone, that's not the full story and due to peculiarities in individual genetics it could be that for some it does in fact interfere with the bupe.
 

opiatekrzy

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All I'm saying simply is, there is a difference in effect between IV suboxone and IV subutex . I'm not going to get in a full fledged scientific debate and summarize theories. I know a lot of people would agree with me and I'm sure other people would disagree with me. At this being said I'm dropping out of the race
 

JessFR

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It's also strange how widespread people who have done it like me, all agree and feel the same way, kind of funny how Subutex prices on my area are higher then Suboxone prices... I guess I must be some special human with special powers.

jessFR- are you speaking from personal experience? Or are you just reading book smarts? Because you can ask any other human being that uses buprenorphine. Wait I suppose now is the time where you are going to say how an addicts mind and placebo is such a power thing? 20yrs of drug use i think I know what is real and what is not. I don't mean to come off like an asshole, but I knew this debate would come up the second I mentioned it. That's my half a penny
I've never used bupe. The only opioid maintainence I've been on is methadone.

I'm not trying to debate anything. I believe you that what you're experiencing is real and not simply in your head. I'm just wondering aloud what the pharmacological reason for it is.

Bupe should have a much higher binding affinity than naloxone. From that you would think that naloxone wouldn't noticeably impact the effects of the buprenorphine.

But it sounds like somehow it does. I just wonder why it does.

Not having experienced it, admitidly I can't say for sure that what you're experiencing is real and not placebo. But I tend to think it's probably real.

I've seen situations with drugs where the reality has seemed at odds with what you'd logically assume before. I think it means our understanding is incomplete.

So yeah, other people might be arguing that what you're experiencing is placebo, but I'm not. Im inclined to believe you that what you're experiencing is real and not all in your head.
 
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