polymath
Bluelight Crew
- Joined
- Nov 4, 2010
- Messages
- 1,884
There seem to be several natural compounds, including magnolol, honokiol and curcumin, that are either CB1 antagonists or agonists with such a functional selectivity that they don't cause an intoxicating effect. Would this mean that something like curcumin (with black pepper to increase bioavailability) could be used as an antidote to cannabinoids if someone has taken too much of them? Or to test whether something has a cannabinoid mechanism of action, e.g. take nutmeg with curcumin to see whether they cancel each others effects.
Honokiol also binds to GABA-A receptors but doesn't cause a significant benzo like effect, does this mean that it could precipitate withdrawal symptoms if taken by someone who's physically dependent on benzodiazepines?
Honokiol also binds to GABA-A receptors but doesn't cause a significant benzo like effect, does this mean that it could precipitate withdrawal symptoms if taken by someone who's physically dependent on benzodiazepines?