Synaps3
Bluelighter
- Joined
- Sep 14, 2011
- Messages
- 257
Can't find any info on that either, however, the 1-adamantanol:
mouse LD50 intraperitoneal 600mg/kg (600mg/kg)
compared to 1-Ethynylcyclohexanol:
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)
That doesn't say much about the actual potency, though.
I was referring to 2-cyclopropyl-2-butanol earlier, but that one could be OK too, but with my limited knowledge, I think that the non-cyclohexanol based tertiary alcohols should have at least somewhat shorter half-life. I think the half-life on the cyclohexanol ones is probably getting a bit too high - especially when adding so many carbons. It may also be steering in the direction of higher selectivity and to mimic alcohol, you want the least selectivity.
But who knows, I'm a novice to this pharmacology stuff anyway, so feel free to correct me.
BTW: This is my favorite site to look up info like LD50 etc (better than MSDS info):
http://chem.sis.nlm.nih.gov/chemidplus/
mouse LD50 intraperitoneal 600mg/kg (600mg/kg)
compared to 1-Ethynylcyclohexanol:
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)
That doesn't say much about the actual potency, though.
1-cyclopropylcyclohexan-1-ol
I was referring to 2-cyclopropyl-2-butanol earlier, but that one could be OK too, but with my limited knowledge, I think that the non-cyclohexanol based tertiary alcohols should have at least somewhat shorter half-life. I think the half-life on the cyclohexanol ones is probably getting a bit too high - especially when adding so many carbons. It may also be steering in the direction of higher selectivity and to mimic alcohol, you want the least selectivity.
But who knows, I'm a novice to this pharmacology stuff anyway, so feel free to correct me.
BTW: This is my favorite site to look up info like LD50 etc (better than MSDS info):
http://chem.sis.nlm.nih.gov/chemidplus/