Hello,
I'm 28 years old, and have been on antidepressants since I was 18. I've tried all sorts of medications except MAOI:s. I'm diagnosed with high functioning autism (or Aspergers), MDD, GAD, OCD and I think one more I've forgotten. Today I would be diagnosed with schizophrenia like symptoms due to my psychosis, but it's probably due to amphetamin use, although I've hold up for several weeks while ingesting 15 mg abilify per day and it's still there, but much weaker.
Today I'm on;:
300 mg Bupropion (which I have no intention of stopping)
67,5 (sic) mg of Mirtazapine (which works but together with methadone I don't have the discipline to keep the weight off; I'm at 253 lbs now)
15 mg of Abilify but I don't use it as I should because I want to use street amphetamine and Abilify is exceptionally good at blocking the D-receptors, but I plan on quitting, and will officially be on 15 mg:s, but iwll really take about up to 5 mg per dag (like 2,5 mg, as this seems to be the better range for depression - probably because at this amount it works as a weak agonist att D-receptors, while already occupying 70 % of D2, and I suppose 15 mg would occupy 90 % (the level of D-occupancy(/occupation?) seems to be following an inverse x^2-graph, hency my supposing about 15 mg)
4 mg trihexyphenidyl which I really don't need but use in higher amounts because of its ability to induce sleep)
100 mg of Methadone per day (this I will increase, and try to switch to Levomethadone due to it having higher affinity for the MOR-receptor, and because - if I remember correctly - it's also a 5-HT and NE reuptake inhibitor
Melatonine, 4 mg per day that I rarely take
Now, I'm trying to get Agomelatine added, and Mirtazapine removed. I fear they won't do this because I had very slightly too high ASAT-levels, but I will try. If I suceeed With changing to Agomelatine instead of Mirtazapine,, then I have no serotonergic effect of my antidepressant medications - should I try completely without something that is serotonergic? Other than Vortioxetine, it has never worked for me anyway. Not even MDMA (tried different sorts of Exctacy as well as pure MDMA) makes me euphoric.
Well, aripiprazole is a partial agonist of the most important receptor - 5-ht1a, although it also affects 5-ht2c in the same way, but much weaker, and probably won't be affected at all by 2,5 mgs.
I'm thinkinf of asking for Vortioxetine if they say no to Agomelatine, should I try and get in on top of what I already have, or discontinue Mirtazapine? The problem is....I want a girl friend, and your **** has to be working, and methadone makes this very problematic, but when on mirtazapine and bupropion it's manageable. No matter, I will just use exogenous testosterone to fix this.
What do you suggest/propose I ask for? And am I thinking correctly regarding what I've written?
best regards and I'm very thankful for all serious answers, even if you're not sure (hell - the combined world's research and doctors and pharmacologists can't solve problems like mine fully, so why should I or you? But please...try)
I'm 28 years old, and have been on antidepressants since I was 18. I've tried all sorts of medications except MAOI:s. I'm diagnosed with high functioning autism (or Aspergers), MDD, GAD, OCD and I think one more I've forgotten. Today I would be diagnosed with schizophrenia like symptoms due to my psychosis, but it's probably due to amphetamin use, although I've hold up for several weeks while ingesting 15 mg abilify per day and it's still there, but much weaker.
Today I'm on;:
300 mg Bupropion (which I have no intention of stopping)
67,5 (sic) mg of Mirtazapine (which works but together with methadone I don't have the discipline to keep the weight off; I'm at 253 lbs now)
15 mg of Abilify but I don't use it as I should because I want to use street amphetamine and Abilify is exceptionally good at blocking the D-receptors, but I plan on quitting, and will officially be on 15 mg:s, but iwll really take about up to 5 mg per dag (like 2,5 mg, as this seems to be the better range for depression - probably because at this amount it works as a weak agonist att D-receptors, while already occupying 70 % of D2, and I suppose 15 mg would occupy 90 % (the level of D-occupancy(/occupation?) seems to be following an inverse x^2-graph, hency my supposing about 15 mg)
4 mg trihexyphenidyl which I really don't need but use in higher amounts because of its ability to induce sleep)
100 mg of Methadone per day (this I will increase, and try to switch to Levomethadone due to it having higher affinity for the MOR-receptor, and because - if I remember correctly - it's also a 5-HT and NE reuptake inhibitor
Melatonine, 4 mg per day that I rarely take
Now, I'm trying to get Agomelatine added, and Mirtazapine removed. I fear they won't do this because I had very slightly too high ASAT-levels, but I will try. If I suceeed With changing to Agomelatine instead of Mirtazapine,, then I have no serotonergic effect of my antidepressant medications - should I try completely without something that is serotonergic? Other than Vortioxetine, it has never worked for me anyway. Not even MDMA (tried different sorts of Exctacy as well as pure MDMA) makes me euphoric.
Well, aripiprazole is a partial agonist of the most important receptor - 5-ht1a, although it also affects 5-ht2c in the same way, but much weaker, and probably won't be affected at all by 2,5 mgs.
I'm thinkinf of asking for Vortioxetine if they say no to Agomelatine, should I try and get in on top of what I already have, or discontinue Mirtazapine? The problem is....I want a girl friend, and your **** has to be working, and methadone makes this very problematic, but when on mirtazapine and bupropion it's manageable. No matter, I will just use exogenous testosterone to fix this.
What do you suggest/propose I ask for? And am I thinking correctly regarding what I've written?
best regards and I'm very thankful for all serious answers, even if you're not sure (hell - the combined world's research and doctors and pharmacologists can't solve problems like mine fully, so why should I or you? But please...try)