(wall of text but read if you want to learn something and have gone through depression)
Hi. That is crucial information that I need to find! The monoamine theory of depression is invented by cavemen and salesmen. Thank you for the info! I will be watching this podcast now. I already love watching Joe Rogan experience.
Monoamines btw means serotonin, dopamine and noradrenaline. These 3 including many metabolites have a STRAIGHT connection to glutamate. If our brain is 80% glutamate networks why not? I am extremely uneducated when comes to this and how do I know something like this? Hell, I even created a account named GlutamateTheory.
I've gone through (2015-16) horrible cycle of depression and the shit that they gave me were mostly damaging. Paroxetine (Paxil) made me crash and it was the beginning of the hell. Then became antipsychotics (they also work on serotonin and dopamine including many connections) that made everything worse probably. Olanzapine, Quetiapine, Risperidone, Aripiprazole, Bupropion, the 2 last were a combo that made me more energized but I was still suicidal.
Yeah, good work on the doctors. Health care is free in my country and that has it's dark side.
Then became substance abuse because I felt helpless but at the same time I started to get interested in these topics. I have background in pharmacy.
Just side thing. Here quick info about glutamate:
https://en.wikipedia.org/wiki/Glutamate_(neurotransmitter)
I just read this and it says glutamate is over 90% of our brain! Wow I was so wrong. I've had wrong info.
There is something else very interesting here. There are something called ''Growth cones'' that are new nerve cells, looking like plant roots! They seek new connections to other nerve cells or dendrites. When you're an adult there are still growth cones going inside your brain.
https://en.wikipedia.org/wiki/Growth_cone
Your comment got me so excited I started to write like a madman
Peace and thank you.