Heart rate lowering on day 3 use of cocaine

[Serotoninfloodz]

Hi folks
I've been using high purity cocaine in Mexico for 3 days. 6 + hours sleep each night, food and good hydration.
Some xanax combined.
Today I notice my HR lower, even aftet lines.
What could cause this?

 

[Mr. Krinkle]

 

[Frazzled1990]

You've been using Cocaine with a Benzo? Your heart rate must be going up and down like a yo-yo. Stimulants+Benzos = big no-no. Benzo's are fine after the come down and you want to get a better sleep. But never use them together. Your heart rate will flip flop all over the place.

 

[4meSM]

You've been using Cocaine with a Benzo? Your heart rate must be going up and down like a yo-yo. Stimulants+Benzos = big no-no. Benzo's are fine after the come down and you want to get a better sleep. But never use them together. Your heart rate will flip flop all over the place.

It's an urban myth. Mixing benzos+stims is physically safe, in fact it really helps when you're overstimulated and it's probably less damaging than stims without benzos.
The risks are overcompensating by taking even more stims, also making an habit of it and becoming mentally and eventually physically addicted to benzos.

 

[Frazzled1990]

It's an urban myth. Mixing benzos+stims is physically safe, in fact it really helps when you're overstimulated and it's probably less damaging than stims without benzos.
The risks are overcompensating by taking even more stims, also making an habit of it and becoming mentally and eventually physically addicted to benzos.

There's no "urban myth" about it. Cocaine stimulates the CNS, Benzo's depress it. You may think it's a simple case of one cancelling out the other. But anybody that has a clue about neurology would tell you otherwise. It sends mixed signals through your cardiovascular system and can quite easily lead to a serious case of heart arrhythmia.

If you want to smoothen out the effects of a stimulant and minimize it's withdrawal potential, then I would recommend taking 400mgs of Chelated Magnesium, 400mgs of L-Theanine and 8gs of Myo-Inositol about an hour before consumption. The Magnesium will regulate the Calcium Ions entering the Axon Terminal, preventing a cascade. The effects of the stimulant will be less intense, but will be longer lasting with a smooth roll off as opposed to a sudden hard crash. It will also help to prevent the blood vessels from restricting, helping to maintain a healthy heart rhythm and blood pressure. Theanine acts as a Glutamate Antagonist and can greatly reduce physical side effects from stimulant use, such as jaw clenching, grinding and muscle twitching/spasms. Inositol acts as a secondary messenger between the neurotransmitters allowing them to function more efficiently with the corresponding receptors. There is also some evidence to suggest that they help to upregulate the catecholamine receptors, counteracting the downregulation effects that long term stimulant consumption can cause.

These 3 supplements are vastly superior in combination with stimulant use and infinitely more safe than a benzo combination.

 

[Mch1]

There's no "urban myth" about it. Cocaine stimulates the CNS, Benzo's depress it. You may think it's a simple case of one cancelling out the other. But anybody that has a clue about neurology would tell you otherwise. It sends mixed signals through your cardiovascular system and can quite easily lead to a serious case of heart arrhythmia.

Why then in hospitals do they give benzos to people who overdose on stims?

 

[Frazzled1990]

Why then in hospitals do they give benzos to people who overdose on stims?

It's something they try to avoid doing if they can. It's not an ideal solution and also depends on how the Amphetamines or Cocaine have been consumed. If they've been consumed orally, then they're unlikely to give a benzo and more likely to give a high concentration of ascorbic acid (vitamin c) to neutralize any excess Amphetamine or Cocaine still making it's way to the brain through the blood stream. If it's been snorted or smoked, then obviously that solution won't be of any help, so they may have to use a benzo at the safest dosage possible to help control anxiety/panic attacks and reduce the possibility of a seizure. But you can be damn sure that they'll have you hooked up to a heart monitor to measure your BPM very closely as well as your blood pressure. They're also likely to give you Magnesium intravenously to help dilate your blood vessels and reduce the chances of clotting from occurring.

Benzo's however are not an ideal substitute for limiting stimulant side effects and should only be used in emergency situations under medical supervision. The combination of supplements I've mentioned in my previous post can greatly reduce the risk of this situation from occurring.

 

[OpiateKiller]

There's no "urban myth" about it. Cocaine stimulates the CNS, Benzo's depress it. You may think it's a simple case of one cancelling out the other. But anybody that has a clue about neurology would tell you otherwise. It sends mixed signals through your cardiovascular system and can quite easily lead to a serious case of heart arrhythmia.

If you want to smoothen out the effects of a stimulant and minimize it's withdrawal potential, then I would recommend taking 400mgs of Chelated Magnesium, 400mgs of L-Theanine and 8gs of Myo-Inositol about an hour before consumption. The Magnesium will regulate the Calcium Ions entering the Axon Terminal, preventing a cascade. The effects of the stimulant will be less intense, but will be longer lasting with a smooth roll off as opposed to a sudden hard crash. It will also help to prevent the blood vessels from restricting, helping to maintain a healthy heart rhythm and blood pressure. Theanine acts as a Glutamate Antagonist and can greatly reduce physical side effects from stimulant use, such as jaw clenching, grinding and muscle twitching/spasms. Inositol acts as a secondary messenger between the neurotransmitters allowing them to function more efficiently with the corresponding receptors. There is also some evidence to suggest that they help to upregulate the catecholamine receptors, counteracting the downregulation effects that long term stimulant consumption can cause.

These 3 supplements are vastly superior in combination with stimulant use and infinitely more safe than a benzo combination.

Good advice on the magnesium, but really it is an urban myth. Benzos IMO are much less hazardous than shooting speedballs. Lots of people smoke crack and shoot dope for long periods of time, which is much more dangerous than benzos for the heart and HR. The respiratory depression from opiates is far greater than benzos

 

[Frazzled1990]

Good advice on the magnesium, but really it is an urban myth. Benzos IMO are much less hazardous than shooting speedballs. Lots of people smoke crack and shoot dope for long periods of time, which is much more dangerous than benzos for the heart and HR. The respiratory depression from opiates is far greater than benzos

I agree that benzo's on their own are generally safe. I'm talking about the combination of stimulants and benzo's together. Some people think it's a good idea to take them together to smoothen out the stimulation effects when there are far better and far safer methods to achieve this.

 

[4meSM]

It's something they try to avoid doing if they can. It's not an ideal solution and also depends on how the Amphetamines or Cocaine have been consumed. If they've been consumed orally, then they're unlikely to give a benzo and more likely to give a high concentration of ascorbic acid (vitamin c) to neutralize any excess Amphetamine or Cocaine still making it's way to the brain through the blood stream. If it's been snorted or smoked, then obviously that solution won't be of any help, so they may have to use a benzo at the safest dosage possible to help control anxiety/panic attacks and reduce the possibility of a seizure. But you can be damn sure that they'll have you hooked up to a heart monitor to measure your BPM very closely as well as your blood pressure. They're also likely to give you Magnesium intravenously to help dilate your blood vessels and reduce the chances of clotting from occurring.

Benzo's however are not an ideal substitute for limiting stimulant side effects and should only be used in emergency situations under medical supervision. The combination of supplements I've mentioned in my previous post can greatly reduce the risk of this situation from occurring.

Benzos (usually diazepam) is pretty much the first thing they would give you in the ER for acute stimulant intoxication. If they hooked you up to a heart monitor it would be to check if your vitals go back to somewhat normal levels, or in case you haven't yet archieved peak plasma for the stimulant (which could cause your HR/BP to keep increasing). It's not because they're afraid introducing benzos to the mix could cause a heart attack or something along those lines, and if it were to happen it would very likely be due to the stimulant itself.

As far as I know there are no dangerous interactions between dopaminergic stimulants and GABA-A positive allosteric modulators, if you disagree please provide a reference.
But yeah they might give you other stuff too depending on your state, obviously benzos wouldn't have the highest priority if you're having a heart attack.

Also vitamin C changes the pH of the urine and makes it more acidic, doing so increases renal excretion of alkaline drugs (from the blood into the urine), so it will work even if you smoked or IVd them. It doesn't exactly neutralize them while on their way to the brain.

 

[Frazzled1990]

Benzos (usually diazepam) is pretty much the first thing they would give you in the ER for acute stimulant intoxication. If they hooked you up to a heart monitor it would be to check if your vitals go back to somewhat normal levels, or in case you haven't yet archieved peak plasma for the stimulant (which could cause your HR/BP to keep increasing). It's not because they're afraid introducing benzos to the mix could cause a heart attack or something along those lines, and if it were to happen it would very likely be due to the stimulant itself.

As far as I know there are no dangerous interactions between dopaminergic stimulants and GABA-A positive allosteric modulators, if you disagree please provide a reference.
But yeah they might give you other stuff too depending on your state, obviously benzos wouldn't have the highest priority if you're having a heart attack.

Also vitamin C changes the pH of the urine and makes it more acidic, doing so increases renal excretion of alkaline drugs (from the blood into the urine), so it will work even if you smoked or IVd them. It doesn't exactly neutralize them while on their way to the brain.

A weak benzo like Diazepam at low to moderate dosages 2-5mgs may be helpful. But there's people on here taking 2mg+ of Xanax and other more potent benzo's. This is not recommended.

Your point about vitamin C increasing the PH level of urine and helping to excrete alkaline drugs is correct. However, this will only work if any of the medication is flowing through the blood stream and the digestive tract. Smoking bypasses the blood stream and so does snorting. It's the fast route into your central nervous system as you're completely bypassing the liver and the blood brain barrier. Rendering vitamin C completely useless, as the full potency of the drug is already in your Central Nervous System within seconds of consumption.