Wait what did you read my entire Post or just one sentence... I just said that the only benefits seem to be just psychological/Mental which falls into the category of Treating Pain since pain is part of your brain telling you have an injury essentially in lack of a better way of explaining it but sorry for any confusion about my post I AGREE with every Sentence you have stated and apologize for any misunderstanding of my Post. I'm suffering from extremely bad back pain that is only going to get worse as I age my Doctor said to Me. I'm using drugs like GABAPentin and Soma and Baclofen with a shit ton of weed to maintain my pain management for long as possible since like you said about being in so much pain that it makes it so you can't even crawl out of bed without crying from the pain and want to pop pain pills so bad but I'm trying to wait until I got no choice since Opioid Management if I get on it again I will be going on it for the rest of my Life which I'm trying to avoid as long as possible.I have to disagee with your first sentence Echo. The major health benefit of opioid use are pain free or less painful feeling that allows chronic pain sufferers the ability to function in society instead of not being able to leave bed from how much they hurt. EVERY medication has a benefit, but most of us on here hope to find a certain benefit in their drug of choice that simply isn't there.
and the fact that it slows your metabolism so you dont get old as fast as common people.
I've seen some seriously haggard looking junkies though and been surprised to find they're much younger than they look. But I guess that could be due to bad diet/other lifestyle issuesWhile I have to agree NZN, it does seem to reduce the appearance of aging, I would love to find some data on it. I will be at work today but if you find any info please share it. It could just be coincidence, correlation doesn't equal causation =/
I certainly agree and have seen plenty of examples -- I think it has slowed down the ageing process in my case, certainly with my grandfather who was on morphine from age 38 to death of old age at 104; morphine and hydromorphone as well as nicomorphine appear to agree quite well with a number of other family members as well. I think it is the slowing of metabolism and possibly some additional protective neurological and/or endocrine effectIt maintains ur youth![]()
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Theres tons of. ppl who have surpassed the 100YEARS MARK using opiates errrday. I think poppyseed tea woyld be the best for this purpose or good old Morphine.
I want @Nicomorphinist opinion on this matter. ?
It was officially used by doctors for this reason well into living memory and some researchers are seeing the wisdom once again, with even oxymorphone being researched for use against intractable depression and bipolar statesI admit it isn't scientific evidence or a physical health benefit, but when I do codeine it improves my mental health a lot. I have severe depression/anxiety, and I don't do it often, once every few months or so, but every time the experience really clears my head, reduces stress, makes me less anxious, etc. for a good while afterwards. No idea if there are any studies on this but it really does seem to be therapeutic even after it's fully left my system.
extremely interesting, now that i've thought about it, I haven't been sick in the years that i've been on high-dose opiates, i think i last even had a cold about 3-4 years agoIt seems that opioid use has the ability to interact with the immune system in a variety of ways. There is data showing that chronic use (this study defines chronic use as 24 months) can suppress the immune system. This may play a factor in why you dont "get sick". In reality you are probably still catching the colds but your body is not responding to the virus and thus the nasty inflammatory response that makes a person feel so shitty is not presenting. But this ultimately is a negative effect of chronic use because you are allowing your body to become more susceptible to disease.
Opioid System Modulates the Immune Function: A Review
This, too, I have noticed, along with one effect of mid-withdrawal being sneezing 50 or 100 times in a row . . .I NEVER EVEN SNEEZED ON AN OPIOID LIFE
never even got a cold itvwas phenomenal !
Now you mention it same here .. and I have to use chronic athsma drugs which as they're strong steroids mean I am imunocompromised (or however you spell that word for the day). These days I only have to use them as my allergic athsma is triggered by opiates (fine with opioids) but every other time I've had to use them god did I get sick as fuck all the time. I even played with my snotty 2 year old niece the other day .. and everybody else got sick and I didn't.extremely interesting, now that i've thought about it, I haven't been sick in the years that i've been on high-dose opiates, i think i last even had a cold about 3-4 years ago
A pharma company recently tried to make a new antidepressant med that was just buprenorphine combined with a novel partial antagonist (added purely so it can be patented basically) and while it was ultimately rejected by the FDA, the given reason was that it was not deemed effective because the antagonist they invented ruined the antidepressant effects of the buprenorphine. The FDA did however vote in favour of it being adequately safe which is I think quite significant.It was officially used by doctors for this reason well into living memory and some researchers are seeing the wisdom once again, with even oxymorphone being researched for use against intractable depression and bipolar states
Does this come down to the politics of the μ opioid receptor? Maybe Alkermes was too clever by half and should have mixed the buprenorphine with omeprazole or cetirizine instead. If they are really counting on the κ opioid receptor to do the anti-depressant work, I cannot imagine that they are going to get very far. The difference amongst κ opioid agonism, antagonism, silent antagonism, inverse agonism, partial agonism and so forth generally are different species of dysphoria, bad body load, and hallucinations for the most part, at least that is what it sounds like . . . and so what if buprenorphine's μ opioid agonism gives it "abuse liability" -- the μ opioid receptor is manifestly the locus of the anti-depressant effect and there cannot really be half-measures involved: treatment-resistant intractable depression can more or less by definition completely incapacitate people, plus all of the other depression medications have serious side effects and withdrawal syndromes much worse than the standard opioid ones, and I never hear of suicidal ideation being a direct side effect of any opioid . . . I did wonder a bit about tapentadol and tramadol when the former was in late development, but apparently not -- the mechanism creating the suicidal ideation from many psych meds in use must be something aside from the serotonin system.A pharma company recently tried to make a new antidepressant med that was just buprenorphine combined with a novel partial antagonist (added purely so it can be patented basically) and while it was ultimately rejected by the FDA, the given reason was that it was not deemed effective because the antagonist they invented ruined the antidepressant effects of the buprenorphine. The FDA did however vote in favour of it being adequately safe which is I think quite significant.
This then opens the door for pharma companies to potentially experiment with other opioid based medications for antidepressant use once again.
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Buprenorphine/samidorphan - Wikipedia
en.wikipedia.org
From reading it seems like the antagonist they combined it with interfered with the effects at the KOR which made the bupe less effective.Does this come down to the politics of the μ opioid receptor? Maybe Alkermes was too clever by half and should have mixed the buprenorphine with omeprazole or cetirizine instead. If they are really counting on the κ opioid receptor to do the anti-depressant work, I cannot imagine that they are going to get very far. The difference amongst κ opioid agonism, antagonism, silent antagonism, inverse agonism, partial agonism and so forth generally are different species of dysphoria, bad body load, and hallucinations for the most part, at least that is what it sounds like . . . and so what if buprenorphine's μ opioid agonism gives it "abuse liability" -- the μ opioid receptor is manifestly the locus of the anti-depressant effect and there cannot really be half-measures involved: treatment-resistant intractable depression can more or less by definition completely incapacitate people, plus all of the other depression medications have serious side effects and withdrawal syndromes much worse than the standard opioid ones, and I never hear of suicidal ideation being a direct side effect of any opioid . . . I did wonder a bit about tapentadol and tramadol when the former was in late development, but apparently not -- the mechanism creating the suicidal ideation from many psych meds in use must be something aside from the serotonin system.
Given that dextromethorphan is showing promise in anti-depressant research, I would think that the racaemic parent opioid, dromoran, which combines DXO and levorphanol, would be the next place to look. I had it years ago in hospital after falling down the marble steps at a train station and breaking an ankle. It did the job admirably, and if they can get levorphanol out of the hands of the Pharmacy Bro and his minions, it should be rather inexpensive too.
really? if by chance do you have a link to any info on that? only if you have the link handy, don't go out of your way...It was officially used by doctors for this reason well into living memory and some researchers are seeing the wisdom once again, with even oxymorphone being researched for use against intractable depression and bipolar states
There is a buprenorphine patch which is very helpful for chronic pain for some people in some cases, and plain buprenorphine tablets are prescribed for similar cases . . . presumably it is much harder for doctors to use Suboxone off-label for pain given that there are extra regulations on it and so forth . . .Why aren't subs used for pain relief more frequently? They're somewhat harder to abuse and for someone with no tolerance they'd be pretty effective I'd think.