cryptix420
Bluelighter
- Joined
- Jul 25, 2010
- Messages
- 1,419
Howdy,
I love ketamine, more than the average joe, and was pretty bummed to say the least when I heard recently it may have much more significant activity at the opioid receptors than has been believed since its invention.
Recently, a study was conducted where individuals were either given ketamine and a placebo, or ketamine and the opioid receptor antagonist naltrexone. The results demonstrated that when opiod receptors were blocked by naltrexone, the much-touted antidepressant properties of ketamine were virtually non-existent.
Sort of scares me, because I love the heck out of ketamine and thought it to be quite benign in a general sense (mind you I'm taking 1-200mg a day insufflated, not railing/IM'ing grams at a time).
What are your thoughts, peeps?
https://med.stanford.edu/news/all-n...e-effects-tied-to-opioid-system-in-brain.html
I love ketamine, more than the average joe, and was pretty bummed to say the least when I heard recently it may have much more significant activity at the opioid receptors than has been believed since its invention.
Recently, a study was conducted where individuals were either given ketamine and a placebo, or ketamine and the opioid receptor antagonist naltrexone. The results demonstrated that when opiod receptors were blocked by naltrexone, the much-touted antidepressant properties of ketamine were virtually non-existent.
Sort of scares me, because I love the heck out of ketamine and thought it to be quite benign in a general sense (mind you I'm taking 1-200mg a day insufflated, not railing/IM'ing grams at a time).
What are your thoughts, peeps?
https://med.stanford.edu/news/all-n...e-effects-tied-to-opioid-system-in-brain.html