Benzodiazepines bind to their receptor on various GABAa heteromeres usually not those combined with a delta unit.
Chamomile bind to the sedative ones only and act as a second order PAM at low dose and antagonist of high GABA levels activation to the receptors while leaving lower activations alone at mostly the same heteromeres as Benzodiazepines.
Kava seems to not only act on a different binding site to increase GABA efficiency but also different heteromere.
What I think is that Low chamomile dose potentiate Benzodiazepines, and Kava potentiate other heteromeres without being linked to BDZ ligand so even if they hit the same Heteromeres as Benzo they wouldnt compete, making a general GABAa potentiation with an effect far less specific and should be able to help with too high voltage in neural cells (Kava also has some other effects on Cathion channels that can help too).
The thing is that I do not know how low of a chamomile dose is needed to avoid the antagonistic effect on High levels of GABA. I read if it went over 10nM it starts this effect but I am unable to find out how much chamomile/Kg is equal to that kind of serum concentration.
So I thought that low dose of Chamomile added to moderate dose of Kava and relatively High dose of benzodiazepines would be totally synergic.
I know the combination of the 3 substances specially if adding Rosmarinic acid from Lemon balm is something that can make me use less amount of BDZ to get the same effect but I don't know the exact dosage of chamomile and Kava to use to make them BDZ potentiator and without having too much that they will fight over a receptor selectivity.
If any1 has an insight about how I can find out the right ratio of every substances to make it the most efficient would be welcome. Since I already know that it is possible All I need is to find the dose of chamomile and kava to use to not overcome the BDZ effect.
Thank you for your time and have a nice day.
Chamomile bind to the sedative ones only and act as a second order PAM at low dose and antagonist of high GABA levels activation to the receptors while leaving lower activations alone at mostly the same heteromeres as Benzodiazepines.
Kava seems to not only act on a different binding site to increase GABA efficiency but also different heteromere.
What I think is that Low chamomile dose potentiate Benzodiazepines, and Kava potentiate other heteromeres without being linked to BDZ ligand so even if they hit the same Heteromeres as Benzo they wouldnt compete, making a general GABAa potentiation with an effect far less specific and should be able to help with too high voltage in neural cells (Kava also has some other effects on Cathion channels that can help too).
The thing is that I do not know how low of a chamomile dose is needed to avoid the antagonistic effect on High levels of GABA. I read if it went over 10nM it starts this effect but I am unable to find out how much chamomile/Kg is equal to that kind of serum concentration.
So I thought that low dose of Chamomile added to moderate dose of Kava and relatively High dose of benzodiazepines would be totally synergic.
I know the combination of the 3 substances specially if adding Rosmarinic acid from Lemon balm is something that can make me use less amount of BDZ to get the same effect but I don't know the exact dosage of chamomile and Kava to use to make them BDZ potentiator and without having too much that they will fight over a receptor selectivity.
If any1 has an insight about how I can find out the right ratio of every substances to make it the most efficient would be welcome. Since I already know that it is possible All I need is to find the dose of chamomile and kava to use to not overcome the BDZ effect.
Thank you for your time and have a nice day.