Interactively, Ketamine should not be used with respiratory depressants, primarily alcohol, barbituates, and Valium. [Note: K is sometimes used with benzodiazepines in human patients to induce amnesia, so they don't remember the hallucinations from the FUCKING HUGE intravenous doses they get. BT]. Ketamine has been used with no ill interactive effects with dope, acid, nitrous, dextromethorphan, and MDMA, although no combinations are recommended and are highly unnecessary given the totality of ketamine. It does not have a build-on effect with halucinagins
(sic) and will generally overpower other drugs. Nitrous in the up and down periods can be effective.
One must take care in predicting the effects of synergies, and we must remember that a little information can be a DANGEROUS thing. There's a large difference between suppression of respiratory function, and suppression of cough/gag reflex...
From the KETASET packaging information:
In contrast to other anesthetics, protective reflexes, such as coughing and swallowing are maintained under KETASET anesthesia. The degree of muscle tone is dependant upon the level of dose; therefore, variations in body temperature may occur.
[...] Although salivation is occasionally noted, the persistence of the swallowing reflex aids in minimizing the hazards associated with ptyalism.
[...] Other reflexes, e.g., corneal, pedal, etc., are maintained during KETASET anesthesia, and should not be used as criteria for judging depth of anesthesia. The eyes normally remain open with the pupils dilated.
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