• N&PD Moderators: sekio | S.J.P.

fluoroquinolone damaged my gaba system?

Sunshine89

Greenlighter
Joined
May 14, 2013
Messages
2
Hy guys,

Im a newbie so please dont be to harsh on me.
I was taking Klonopin and i took one month ago an antibiotic which had a GABA antagonist effect and it sais its inhibiting the GABA receptor site by binding on it. since then i had to up my Klonopin dose from 0.25mg per day to 2mg per day to have the same benefits.. How long will it take for this antagonist effect to go away? Will it at least EVER go away? i hope you understand what i mean...im not very much into this...

Thank you.
 

sekio

Moderator: N&PD
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Sep 14, 2009
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streets of simcity
Unfortunately, nobody can tell you when you're going to get better. This is like asking "I got a cut on my foot, when will it heal?" It depends on so much that you're not telling us... it could heal overnight, or maybe it will take years to heal. How big is the wound? What caused it? Are you treating it properly? Are you stressing it? Do you eat a proper diet? Are you naturally a slow healer?

As I posted in your other thread, the acute reactions to fluoroquinolones are reported to be over in 72 hours, with total recovery in some cases taking several months. It is impossible to tell ahead of time which of those groups you belong to though.

Concentrate on symptomatic treatment and you will feel better in due time. If you stand around feeling bad for yourself it won't help.

Talk to your doctor.
 

Sunshine89

Greenlighter
Joined
May 14, 2013
Messages
2
Too bad i live in a shitty country where the doctors dont believe me. okay, thanks for your answers Sekio.
 

sekio

Moderator: N&PD
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Further reading...

Five hundred ninety cases have been reported concerning 273 males and 316 females (sex unknown in 1 case). [...] For most patients, the outcome was favorable: in 88.5% of cases, there was complete regression of the effect; in 9.5% of cases, development was in progress or unknown. Eleven deaths occurred (1.9%): eight were unrelated and two related to another adverse effect, only one death could be due to psychiatric AEs, in a woman of 92 years treated for 24 hours 800 mg / day of oral pefloxacin that committed suicide.
https://www.ncbi.nlm.nih.gov/pubmed/16580096

Some cases seem to persist after months to years though.
http://fqvictims.org/fqvictims/News/neuropathy/Neuropathy.pdf

The mechanism of FQ toxicity may not be GABA-dependent, adenosine receptors may play a role too (for instance caffeine is an adenosine receptor antagonist)
Most of the compounds did not alter 3H-diazepam binding directly, although rosoxacin showed relatively strong, and enoxacin weak, concentration-dependent inhibition. At 50 μM the compounds enhanced the maximal γ-aminobutyric acid (GABA) activation of 3H-diazepam binding to varying degrees, without altering the EC50 of activation, whereas at 200 μM they tended to reduce GABA activation.
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0773.1989.tb00676.x/abstract
 
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