Once had a friend sneaking to my stash behind my back and snorting a fat line of methoxetamine. Was in the times when it was still legal, maybe 2011 or so. She took enough for to reach dissociative anesthesia where one is in deep, unwakeable sleep but I didn't know this for sure back then (should reach this state numerous times myself later and realize it didn't pose much danger as it's just how ketamine is used clinically, so technically not even an OD) and was scared as hell that both I could be responsible morally for somebody being injured or death as well as the legal implications thereof.. was my affair and I had to hide the whole stuff from my then-girlfriend (should just have quit the relationship when things weren't so good anymore yeah but young and stupid).. so I had this comatose girl on my couch and a date with said gf.. needed to decide what to do, call the emergency or not.. I didn't call them, and as said turned out that with dissociatives it's not necessary but it was a coward turn of me, it's always better to call the paramedics and in some places like Europe you don't need to fear any punishment as long as you call only the paramedics, they don't inform the police but afaik in America cops are inevitable.. then just flush whatever drugs are around (or stash them damn well if possible) and keep the concerned individual breathing. Just keep your mouth shut against the police. Tell them that it's an OD and not more. Not who had which drugs, not which amount, that's for the docs to find out. Just that naloxone is needed, who you are, and that's it. They needa accept that you won't incriminate yourself.
Once I overdosed myself with butyr fentanyl, felt that something was wrong (not sure whether od or impurity) and at that point didn't want to die so emergency. Snorted some tilidine/naloxone pill which reversed the sedation somewhat yet wasn't sure if it was enough/for long enough.. But then another cowardish asshole which happened to be my landlord at that time, was still awake (like 1:30 am) and decided that he'd be faster than the paras so he drove me himself. I wasn't passing out but nearly so, could barely speak etc. - I told all the staff that he didn't know about my use and he assured me not to call the cops but later still did and they raided my (pretty well sorted) stash. I fucking hate this person, I was into prison with one leg cause of his cowardism. But yeah I am still thankful that the girl above survived and I don't have to live with the guilt of somebodys death or brain damage, and guess I can't really blame this guy. he just didn't know that nobody would be after him guess even if I had died when he has nothing to do whatsoever with drugs..
Yeah as G_Chem said, stims can indeed save lives or comfort of life (as in avoiding drain bamage), it's not what a doc would recommend but it works. Dissociatives are similar btw, low doses of them are stimulatory and NMDA antagonism protects against hypoxia induced brain damage. Just massage the stuff into the nose I guess or inject if a sterile set is available.