Girlwithbluehair, have you tried any selective AMPAkines?
I ask because I intend to at least trial sunifiram/DM-235, a 'true' AMPAkine, in the sense of not having some indistinct mechanism of action like E.g piracetam and known mechanism, elucidated by and characterised with electrophysiological studies under patch-clamp conditions.
BUT, I am not going to start it before getting on memantine, and my fucking doctors have for years been content to let me rot more or less. They know memantine itself (tried it for quite some time in combination with galantamine, and the memantine quite literally was the difference between functioning, between being able to not go so hungry because I can't even make food on my bad days, I'd just stand there, in front of it, staring at the wall, unable to make myself move and do it, despite being desperately hungry. My short term, and working memory, as well as ability to consolidate and retain long-term memory is shot, and of recent times my semantic memory has been going too. As has my executive functioning been gone for the most part for many years. My mother has MS, and dementia, and they have destroyed her. I am physically capable of movement unlike her. But now as of recently she was taken into hospital, and most likely she will not live much longer.
But I have watched her. For years and years and years, watched her slowly ROT, decaying like a piece of fucking meat, she doesn't (or didn't. Don't know if she is ever getting out of hospital, we think it unlikely and if she does it will have to be palliative nursing as end of life care because we cannot do it. The sooner she drops dead the fucking better, sound mean? because its not, its far far from it, because the reaper's scythe will be a mercy for her when finally it severs her thread of life, if 'life' came close to what shes stick in now, forced continuation of existence is more accurate.)
Shes turned into a bipedal (not that the legs or anything else WORKS mind you) mammalian cabbage, and I am NOT going to allow that to happen to me. If it means getting permission from the person who holds my life in her hands, to blow my brains out while I still can then so be it. But I'd sooner, far, far, far infinitely sooner, work on what I can while I can to reverse this shit. But I can't find the memantine nor get the precursor dimethyladamantanol or dimethyladamantanyl chloride to produce memantine for myself. And cannot buy it either.
Since GABAb agonism induces a lessening of glutamate release, how about partial negative allosteric modulation? could this be responsible.
