Vastness
Bluelight Crew
- Joined
- Mar 10, 2006
- Messages
- 2,306
Recently have become interested in etifoxine - brand name "Stresam" in Russia - a non-benzodiazepine anxiolytic, apparently without any significant tolerance, and indeed few negatives at all, except for the unfortunate fact that a very small proportion of patients (30, apparently, since 1995, according to a study from 2012 - https://www.ncbi.nlm.nih.gov/pubmed/22633197) developed hepatitis with a median time of 18 days, varying from 11 to 61 days. At least one of these patients ended up requiring a transplant.
Obviously this is a very small amount of people relative to the total amount of people who have been prescribed this which is probably thousands, but I'm still a little concerned. I am taking it currently, 200mg / day, but plan to take it for no longer than 7 days. I'm also going to get a liver function test shortly after. I mean, I figure that serious liver injury isn't something that would just sneak up on you... right? Surely I should expect to experience some kind of symptoms before it became irreversible?
Anyway, there seems to be precious little information on the actual mechanism behind this effect, so I would be interested to hear if anyone would care to speculate.
I know a lot of substances, even ones widely considered to be "safe" have the odd serious adverse reactions in a very small proportion of the population, like modafinil for example which I also take semi-regularly despite the possible danger of Stephen-Johnson's syndrome... however the apparent seriousness of etifoxine's extreme outlier dangers are a little more concerning, although I don't plan to take it long term.
Obviously this is a very small amount of people relative to the total amount of people who have been prescribed this which is probably thousands, but I'm still a little concerned. I am taking it currently, 200mg / day, but plan to take it for no longer than 7 days. I'm also going to get a liver function test shortly after. I mean, I figure that serious liver injury isn't something that would just sneak up on you... right? Surely I should expect to experience some kind of symptoms before it became irreversible?
Anyway, there seems to be precious little information on the actual mechanism behind this effect, so I would be interested to hear if anyone would care to speculate.
I know a lot of substances, even ones widely considered to be "safe" have the odd serious adverse reactions in a very small proportion of the population, like modafinil for example which I also take semi-regularly despite the possible danger of Stephen-Johnson's syndrome... however the apparent seriousness of etifoxine's extreme outlier dangers are a little more concerning, although I don't plan to take it long term.