hi guys,
amphetamine type drugs act on both the noradrenalin and dopamine areas in the brain. there is a theory that suggests that schizophrenia can be caused by excess dopamine production -- thus amphetamine binges can create temporary schizophrenia like symptoms. in addition lack of sleep can certainly make u feel loopy even without drugs!! haha..
some info i've found -->
The DA theory of schizophrenia
According to the DA (dopamine) theory,
schizophrenia is associated with increased activity at dopaminergic receptor sites
antipsychotic drugs exert their clinical effect by reducing increased DA activity.
which leads to predictions that:
drugs which increase DA activity should produce schizophrenia
drugs which decrease DA activity should reduce schizophrenia
Comparison of amphetamine psychosis and paranoid schizophrenia
Another clue that schizophrenia might involve increased dopaminergic activity was provided by the observation that people who take high doses of amphetamine for many days can develop amphetamine psychosis - a drug-induced mental state which could be mistaken for paranoid schizophrenia.
Although it is now clear that amphetamine psychosis and paranoid schizophrenia are not identical, the similarities between the states motivated research designed to explore the biochemical and behavioural effects of amphetamine in animals in order to understand the role of dopamine in behaviour and to develop medicines to treat schizophrenia
Pls check out this link for more info --
http://salmon.psy.plym.ac.uk/year1/schizophrenia.htm#schizophrenia_fact_fiction
furthermore - from personal experience its f*cking scary - and made more so if you have done anything *dodgy* in your means of acquiring the drugs -- however, if everything is cool and harmonious in your life - even if u do lose it - its a lot more bearable!!