- Oct 20, 2008
NEW CAR SMELL
For a start - then I suppose we can all guess where the HCl shows up? Indeed, why would the god of chemistry see fit to add just 1 meta acyl group? I suppose Levophacetoperane is the closest so maybe it's worth dredging through all that to discover that it doesn't offer any help at all.wouldn't the acyl chloride in the precursor also react with the nitrogen in the piperidine ring to form amide?
Nope. Ann acyl chloride will bind to the basic N first and who is to say where else and how many other times will be an issue.If 2-carboxypiperidine is added dropwise as the limiting reagent in a large excess of benzene, it won't be a problem.